The GOA database: gene Ontology annotation updates for 2015.
Bottom Line: The resource now provides annotations to five times the number of proteins it did 4 years ago.As a member of the GO Consortium, we adhere to the most up-to-date Consortium-agreed annotation guidelines via the use of quality control checks that ensures that the GOA resource supplies high-quality functional information to proteins from a wide range of species.Annotations from GOA are freely available and are accessible through a powerful web browser as well as a variety of annotation file formats.
Affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK firstname.lastname@example.org.Show MeSH
Mentions: The most valuable feature of Protein2GO is its many inbuilt quality checks that prevent incorrectly formulated GO annotations from being added to the database. This is beneficial to both trainee and experienced curators as the rules for GO annotation become ever more complex. An example of one of these integral checks is shown in Figure 1. According to GO Consortium guidance, the evidence code ‘IC’ (Inferred by Curator) must refer to another GO term in the ‘With/From’ field of the annotation that has been used in a second annotation for the protein being curated. If no GO term is entered, or if a text string other than a GO term is entered, the curator is prevented from adding the annotation to the database. A warning is given detailing what the curator must rectify before the annotation is acceptable. A subsequent quality control check reports any IC-evidenced annotations that use a GO term in the ‘With/From’ field for which no experimentally evidenced annotations exist in that protein record.
Affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK email@example.com.