MatrixDB, the extracellular matrix interaction database: updated content, a new navigator and expanded functionalities.
Bottom Line: Filters may be applied to build sub-networks based on a list of biomolecules, a specified interaction detection method and/or an expression level by tissue, developmental stage, and health state (UniGene data).Any molecule of the network may be selected and its partners added to the network at any time.Networks may be exported under Cytoscape and tabular formats and as images, and may be saved for subsequent re-use.
Affiliation: UMR 5086 CNRS - Université Lyon 1, 69367 Lyon Cedex 07, France.Show MeSH
Related in: MedlinePlus
Mentions: When browsing MatrixDB, the user can select any publication, biomolecule or UniProtKB keyword and build the corresponding interaction network via iNavigator, a novel interactome network navigator we have developed (Figure 3). The selected items are collected in a cart, which is available on all MatrixDB web pages, and can be deleted from the cart at any time. Interaction networks may be modified either by changing the cart content or by clicking and dragging elements directly on the network. The network can be expanded either by adding the partners and interactions of biomolecules selected within the displayed network, or by querying MatrixDB via the search bar for further publications, biomolecules and keywords. New partners and interactions are added in real time. The process can be repeated iteratively to increase network coverage. Conversely, the user can delete biomolecules and interactions from the network.
Affiliation: UMR 5086 CNRS - Université Lyon 1, 69367 Lyon Cedex 07, France.