PTMcode v2: a resource for functional associations of post-translational modifications within and between proteins.
Bottom Line: These two processes are interdependent and together are responsible for the function of the protein in a particular cell state.Several databases focus on the prediction and compilation of protein-protein interactions (PPIs) and no less on the collection and analysis of protein post-translational modifications (PTMs), however, there are no resources that concentrate on describing the regulatory role of PTMs in PPIs.In total, we report 8 million associations of PTMs regulating single proteins and over 9.4 million interplays tuning PPIs.
Affiliation: European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, 69117 Heidelberg, Germany.Show MeSH
Mentions: Thus, although propagated PTMs should be taken with much caution and used only for exploratory analyses, they exhibit a reasonable overlap with known PTMs as a good indicator for their reliability. By this simple exercise we obtained 1 347 165 sites with a modification signal propagated from verified PTMs allowing us to produce post-translational information for species that otherwise count with almost none experimental data (Figure 2).
Affiliation: European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, 69117 Heidelberg, Germany.