ADReCS: an ontology database for aiding standardization and hierarchical classification of adverse drug reaction terms.
Bottom Line: They have caused significant clinical burden and been responsible for a large portion of new drug development failure.It also incorporates information of 1355 single active ingredient drugs and 134,022 drug-ADR pairs.In summary, ADReCS offers an opportunity for direct computation on ADR terms and also provides clues to mining common features underlying ADRs.
Affiliation: State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, P.R. China.Show MeSH
Related in: MedlinePlus
Mentions: Currently, the ADReCS covers total 6544 standard ADR terms and 34 796 synonyms. The standard ADR terms are classified into 26 SOCs, 322 HLGTs, 1290 HLTs and 4906 PTs. Majority (4879 out of 4906, or 99.4%) of ADReCS PTs are overlapped with MedDRA PTs except 27 new terms (Supplementary Table S1). Besides, 21 468 ADR terms (including synonyms) can be mapped into the UMLS. Of 6544 standard ADR terms, 2078 were given with explicit and univocal definitions. Moreover, ADReCS also includes 1355 single active ingredient drugs and 134 022 non-redundant drug–ADR pairs. A preliminary statistic of the database was demonstrated, showing that altogether, ∼60% of drugs can induce ∼10 to 100 different ADRs (Figure 3A). About 70% of ADRs occur to less than 10 drugs and only 7% of all ADRs occur to more than 100 drugs (Figure 3B). It seems that most drugs can induce multiple ADRs and most ADRs are rare ADRs occurring to few drugs. These results are roughly agreed with the statistics of SIDER2 (12). In addition, 50 490 (or 38%) of all drug–ADR pairs have frequency information, including 17 171 (or 34%) pairs with exact frequency and 33 319 (or 66%) pairs with frequency range. Statistics of drug–ADR pairs by the ADR frequency (Figure 3C and D) suggests that majority of ADRs (∼80%) occur in small frequency (<5%). The median frequency of ‘frequent’ ADRs (occurring in >1% of patients) is ∼4%.
Affiliation: State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, P.R. China.