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IMGT®, the international ImMunoGeneTics information system® 25 years on.

Lefranc MP, Giudicelli V, Duroux P, Jabado-Michaloud J, Folch G, Aouinti S, Carillon E, Duvergey H, Houles A, Paysan-Lafosse T, Hadi-Saljoqi S, Sasorith S, Lefranc G, Kossida S - Nucleic Acids Res. (2014)

Bottom Line: The concepts include the IMGT(®) standardized keywords (identification), IMGT(®) standardized labels (description), IMGT(®) standardized nomenclature (classification), IMGT unique numbering and IMGT Colliers de Perles (numerotation).IMGT(®) comprises 7 databases, 17 online tools and 15,000 pages of web resources, and provides a high-quality and integrated system for analysis of the genomic and expressed IG and TR repertoire of the adaptive immune responses, including NGS high-throughput data.The IMGT/mAb-DB interface was developed for therapeutic antibodies and fusion proteins for immunological applications (FPIA).

View Article: PubMed Central - PubMed

Affiliation: IMGT, the international ImMunoGeneTics information system, Université de Montpellier, Laboratoire d'ImmunoGénétique Moléculaire LIGM, UPR CNRS 1142, Institut de Génétique Humaine IGH, 141 rue de la Cardonille, Montpellier, 34396 cedex 5, France Marie-Paule.Lefranc@igh.cnrs.fr.

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IMGT/mAb-DB, http://www.imgt.org. The part of the results for two entries is shown with the links to IMGT/2Dstructure-DB and IMGT/3Dstructure-DB, respectively.
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Figure 2: IMGT/mAb-DB, http://www.imgt.org. The part of the results for two entries is shown with the links to IMGT/2Dstructure-DB and IMGT/3Dstructure-DB, respectively.

Mentions: A new database and interface, IMGT/mAb-DB (12), http://www.imgt.org, has been developed to provide an easy access to therapeutic antibody AA sequences (links to IMGT/2Dstructure-DB) and structures (links to IMGT/3Dstructure-DB, if 3D structures are available) (Figure 2). IMGT/mAb-DB data include monoclonal antibodies (mAb, INN suffix –mab) (a –mab is defined by the presence of at least an IG variable domain) and fusion proteins for immune applications (FPIA, INN suffix –cept) (a –cept is defined by a receptor fused to a Fc) from the WHO-INN programme (39,40). This database also includes a few CPCA (e.g. protein or peptide fused to a Fc for only increasing their half-life, identified by the INN prefix ef–) and some RPI used, unmodified, for clinical applications.


IMGT®, the international ImMunoGeneTics information system® 25 years on.

Lefranc MP, Giudicelli V, Duroux P, Jabado-Michaloud J, Folch G, Aouinti S, Carillon E, Duvergey H, Houles A, Paysan-Lafosse T, Hadi-Saljoqi S, Sasorith S, Lefranc G, Kossida S - Nucleic Acids Res. (2014)

IMGT/mAb-DB, http://www.imgt.org. The part of the results for two entries is shown with the links to IMGT/2Dstructure-DB and IMGT/3Dstructure-DB, respectively.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383898&req=5

Figure 2: IMGT/mAb-DB, http://www.imgt.org. The part of the results for two entries is shown with the links to IMGT/2Dstructure-DB and IMGT/3Dstructure-DB, respectively.
Mentions: A new database and interface, IMGT/mAb-DB (12), http://www.imgt.org, has been developed to provide an easy access to therapeutic antibody AA sequences (links to IMGT/2Dstructure-DB) and structures (links to IMGT/3Dstructure-DB, if 3D structures are available) (Figure 2). IMGT/mAb-DB data include monoclonal antibodies (mAb, INN suffix –mab) (a –mab is defined by the presence of at least an IG variable domain) and fusion proteins for immune applications (FPIA, INN suffix –cept) (a –cept is defined by a receptor fused to a Fc) from the WHO-INN programme (39,40). This database also includes a few CPCA (e.g. protein or peptide fused to a Fc for only increasing their half-life, identified by the INN prefix ef–) and some RPI used, unmodified, for clinical applications.

Bottom Line: The concepts include the IMGT(®) standardized keywords (identification), IMGT(®) standardized labels (description), IMGT(®) standardized nomenclature (classification), IMGT unique numbering and IMGT Colliers de Perles (numerotation).IMGT(®) comprises 7 databases, 17 online tools and 15,000 pages of web resources, and provides a high-quality and integrated system for analysis of the genomic and expressed IG and TR repertoire of the adaptive immune responses, including NGS high-throughput data.The IMGT/mAb-DB interface was developed for therapeutic antibodies and fusion proteins for immunological applications (FPIA).

View Article: PubMed Central - PubMed

Affiliation: IMGT, the international ImMunoGeneTics information system, Université de Montpellier, Laboratoire d'ImmunoGénétique Moléculaire LIGM, UPR CNRS 1142, Institut de Génétique Humaine IGH, 141 rue de la Cardonille, Montpellier, 34396 cedex 5, France Marie-Paule.Lefranc@igh.cnrs.fr.

Show MeSH
Related in: MedlinePlus