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Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.

Hromatka BS, Tung JY, Kiefer AK, Do CB, Hinds DA, Eriksson N - Hum. Mol. Genet. (2015)

Bottom Line: Despite high heritability, no associated genetic factors have been discovered.We show that several of these SNPs display sex-specific effects, with up to three times stronger effects in women.These results point to the importance of the nervous system in motion sickness and suggest a role for glucose levels in motion-induced nausea and vomiting, a finding that may provide insight into other nausea-related phenotypes like PONV.

View Article: PubMed Central - PubMed

Affiliation: Product Science, 23andMe, Inc., Mountain View, CA, USA bhromatka@23andme.com.

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Related in: MedlinePlus

Manhattan plot. The 35 genome-wide-significant regions are listed with the proposed candidate gene; regions that are close together share a label.
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DDV028F1: Manhattan plot. The 35 genome-wide-significant regions are listed with the proposed candidate gene; regions that are close together share a label.

Mentions: We performed a GWAS in 80 494 individuals from the customer base of 23andMe, Inc., a personal genetics company. Participants were of primarily European ancestry and were at most distantly related to each other (i.e. first cousins and closer were excluded). Motion sickness was assessed using online self-report. Participants responded to questions about their degree of car sickness on a scale of 0 (never motion sick), 1 (occasionally), 2 (sometimes) or 3 (frequently) as described in the Materials and Methods. Details about the cohort can be found in Table 1 and in the Materials and Methods. All analyses were controlled for age, sex and five principal components of genetic ancestry. Manhattan and quantile–quantile plots are provided in Figure 1 and Supplementary Material, Figure S1. The genomic control inflation factor was 1.156.Table 1.


Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.

Hromatka BS, Tung JY, Kiefer AK, Do CB, Hinds DA, Eriksson N - Hum. Mol. Genet. (2015)

Manhattan plot. The 35 genome-wide-significant regions are listed with the proposed candidate gene; regions that are close together share a label.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383869&req=5

DDV028F1: Manhattan plot. The 35 genome-wide-significant regions are listed with the proposed candidate gene; regions that are close together share a label.
Mentions: We performed a GWAS in 80 494 individuals from the customer base of 23andMe, Inc., a personal genetics company. Participants were of primarily European ancestry and were at most distantly related to each other (i.e. first cousins and closer were excluded). Motion sickness was assessed using online self-report. Participants responded to questions about their degree of car sickness on a scale of 0 (never motion sick), 1 (occasionally), 2 (sometimes) or 3 (frequently) as described in the Materials and Methods. Details about the cohort can be found in Table 1 and in the Materials and Methods. All analyses were controlled for age, sex and five principal components of genetic ancestry. Manhattan and quantile–quantile plots are provided in Figure 1 and Supplementary Material, Figure S1. The genomic control inflation factor was 1.156.Table 1.

Bottom Line: Despite high heritability, no associated genetic factors have been discovered.We show that several of these SNPs display sex-specific effects, with up to three times stronger effects in women.These results point to the importance of the nervous system in motion sickness and suggest a role for glucose levels in motion-induced nausea and vomiting, a finding that may provide insight into other nausea-related phenotypes like PONV.

View Article: PubMed Central - PubMed

Affiliation: Product Science, 23andMe, Inc., Mountain View, CA, USA bhromatka@23andme.com.

Show MeSH
Related in: MedlinePlus