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Clinicopathologic features of 112 cases with mantle cell lymphoma.

Zhou DM, Chen G, Zheng XW, Zhu WF, Chen BZ - Cancer Biol Med (2015)

Bottom Line: A break in the CCND1 gene was not found in 3 cases with CD5-MCL.The prognoses of blastoid and polymorphic subtypes are poor.Special subtypes should be classified during diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Key Laboratory of Cancer Translational Medicine of Fujian, Teaching Hospital of Fujian Medical University, Fujian Tumor Hospital, Fuzhou 350014, China.

ABSTRACT

Objective: This study aims to explore the clinicopathologic features of 112 patients with mantle cell lymphoma (MCL).

Methods: Data from 112 MCL cases were collected, and immunohistochemical assay was conducted. Fluorescence in situ hybridization (FISH) detected a break in the CCND1 gene. The t-test was used in the statistical analysis.

Results: All tumor cells in the 112 cases expressed B cell-related antigen, including 1 blastoid subtype and 1 polymorphic subtype. Among all cases, 106 expressed CD5 and 104 expressed cyclin D1. A break in the CCND1 gene was not found in 3 cases with CD5-MCL. IgH/CCND1 polyploid was observed in 2 classic cases.

Conclusion: MCL is a type of special immunophenotypic B-cell lymphoma. The prognoses of blastoid and polymorphic subtypes are poor. Special subtypes should be classified during diagnosis.

No MeSH data available.


Related in: MedlinePlus

FISH image of MCL showing the CCND1 gene disruption (FISH, ×1,000); red/green signals marked the two ends of the CCND1 gene. A positive pattern showed two separate red and green signals. FISH, fluorescence in situ hybridization; MCL, mantle cell lymphoma.
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f5: FISH image of MCL showing the CCND1 gene disruption (FISH, ×1,000); red/green signals marked the two ends of the CCND1 gene. A positive pattern showed two separate red and green signals. FISH, fluorescence in situ hybridization; MCL, mantle cell lymphoma.

Mentions: The FISH results of 6 cases with negative cyclin D1 in MCL showed that the cell number of red and green separated signals was greater than 15%, indicating that chromosome translocation t (11;14) (q13;q32) existed. Among 8 cases of CD5 negative and cyclin D1 positive, 5 cases with the FISH results showed that the cell number of red and green separated signals was greater than 15%. This result implies that chromosome translocation t (11;14) (q13;q32) existed (Figure 5). The FISH results of 10 cases of CD5 positive and cyclin D1 positive in MCL showed that the cell number of red and green separated signals was greater than 15%, indicating the presence of chromosome translocation t (11;14) (q13;q32). Chromosome polyploidy appeared in 2 cases of them (Figure 6).


Clinicopathologic features of 112 cases with mantle cell lymphoma.

Zhou DM, Chen G, Zheng XW, Zhu WF, Chen BZ - Cancer Biol Med (2015)

FISH image of MCL showing the CCND1 gene disruption (FISH, ×1,000); red/green signals marked the two ends of the CCND1 gene. A positive pattern showed two separate red and green signals. FISH, fluorescence in situ hybridization; MCL, mantle cell lymphoma.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383843&req=5

f5: FISH image of MCL showing the CCND1 gene disruption (FISH, ×1,000); red/green signals marked the two ends of the CCND1 gene. A positive pattern showed two separate red and green signals. FISH, fluorescence in situ hybridization; MCL, mantle cell lymphoma.
Mentions: The FISH results of 6 cases with negative cyclin D1 in MCL showed that the cell number of red and green separated signals was greater than 15%, indicating that chromosome translocation t (11;14) (q13;q32) existed. Among 8 cases of CD5 negative and cyclin D1 positive, 5 cases with the FISH results showed that the cell number of red and green separated signals was greater than 15%. This result implies that chromosome translocation t (11;14) (q13;q32) existed (Figure 5). The FISH results of 10 cases of CD5 positive and cyclin D1 positive in MCL showed that the cell number of red and green separated signals was greater than 15%, indicating the presence of chromosome translocation t (11;14) (q13;q32). Chromosome polyploidy appeared in 2 cases of them (Figure 6).

Bottom Line: A break in the CCND1 gene was not found in 3 cases with CD5-MCL.The prognoses of blastoid and polymorphic subtypes are poor.Special subtypes should be classified during diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Key Laboratory of Cancer Translational Medicine of Fujian, Teaching Hospital of Fujian Medical University, Fujian Tumor Hospital, Fuzhou 350014, China.

ABSTRACT

Objective: This study aims to explore the clinicopathologic features of 112 patients with mantle cell lymphoma (MCL).

Methods: Data from 112 MCL cases were collected, and immunohistochemical assay was conducted. Fluorescence in situ hybridization (FISH) detected a break in the CCND1 gene. The t-test was used in the statistical analysis.

Results: All tumor cells in the 112 cases expressed B cell-related antigen, including 1 blastoid subtype and 1 polymorphic subtype. Among all cases, 106 expressed CD5 and 104 expressed cyclin D1. A break in the CCND1 gene was not found in 3 cases with CD5-MCL. IgH/CCND1 polyploid was observed in 2 classic cases.

Conclusion: MCL is a type of special immunophenotypic B-cell lymphoma. The prognoses of blastoid and polymorphic subtypes are poor. Special subtypes should be classified during diagnosis.

No MeSH data available.


Related in: MedlinePlus