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Clinicopathologic features of 112 cases with mantle cell lymphoma.

Zhou DM, Chen G, Zheng XW, Zhu WF, Chen BZ - Cancer Biol Med (2015)

Bottom Line: A break in the CCND1 gene was not found in 3 cases with CD5-MCL.The prognoses of blastoid and polymorphic subtypes are poor.Special subtypes should be classified during diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Key Laboratory of Cancer Translational Medicine of Fujian, Teaching Hospital of Fujian Medical University, Fujian Tumor Hospital, Fuzhou 350014, China.

ABSTRACT

Objective: This study aims to explore the clinicopathologic features of 112 patients with mantle cell lymphoma (MCL).

Methods: Data from 112 MCL cases were collected, and immunohistochemical assay was conducted. Fluorescence in situ hybridization (FISH) detected a break in the CCND1 gene. The t-test was used in the statistical analysis.

Results: All tumor cells in the 112 cases expressed B cell-related antigen, including 1 blastoid subtype and 1 polymorphic subtype. Among all cases, 106 expressed CD5 and 104 expressed cyclin D1. A break in the CCND1 gene was not found in 3 cases with CD5-MCL. IgH/CCND1 polyploid was observed in 2 classic cases.

Conclusion: MCL is a type of special immunophenotypic B-cell lymphoma. The prognoses of blastoid and polymorphic subtypes are poor. Special subtypes should be classified during diagnosis.

No MeSH data available.


Related in: MedlinePlus

CD5+ CD10+ MCL. (A) Tumor cells showed a classic morphology, with the residual germinal center on the left (H&E, ×400); (B) Immunohistochemistry: cyclin D1 (+) (Envision, ×400); (C) CD5 (−) (Envision, ×400); (D) CD10 (+) (Envision, ×400). MCL, mantle cell lymphoma.
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f4: CD5+ CD10+ MCL. (A) Tumor cells showed a classic morphology, with the residual germinal center on the left (H&E, ×400); (B) Immunohistochemistry: cyclin D1 (+) (Envision, ×400); (C) CD5 (−) (Envision, ×400); (D) CD10 (+) (Envision, ×400). MCL, mantle cell lymphoma.

Mentions: All of the 112 cases showed CD20, CD79a, and Pax5 positive, and CD3, CD10, CD21, CD23, and TdT negative. There were 106 cases with cyclin D1 positive, 6 cases with cyclin D1 negative, 104 cases with CD5 positive, 8 cases with CD5 negative, and 1 case with CD5 negative and CD10 positive (Figure 4). Ki-67 index was 5% to 90%.


Clinicopathologic features of 112 cases with mantle cell lymphoma.

Zhou DM, Chen G, Zheng XW, Zhu WF, Chen BZ - Cancer Biol Med (2015)

CD5+ CD10+ MCL. (A) Tumor cells showed a classic morphology, with the residual germinal center on the left (H&E, ×400); (B) Immunohistochemistry: cyclin D1 (+) (Envision, ×400); (C) CD5 (−) (Envision, ×400); (D) CD10 (+) (Envision, ×400). MCL, mantle cell lymphoma.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383843&req=5

f4: CD5+ CD10+ MCL. (A) Tumor cells showed a classic morphology, with the residual germinal center on the left (H&E, ×400); (B) Immunohistochemistry: cyclin D1 (+) (Envision, ×400); (C) CD5 (−) (Envision, ×400); (D) CD10 (+) (Envision, ×400). MCL, mantle cell lymphoma.
Mentions: All of the 112 cases showed CD20, CD79a, and Pax5 positive, and CD3, CD10, CD21, CD23, and TdT negative. There were 106 cases with cyclin D1 positive, 6 cases with cyclin D1 negative, 104 cases with CD5 positive, 8 cases with CD5 negative, and 1 case with CD5 negative and CD10 positive (Figure 4). Ki-67 index was 5% to 90%.

Bottom Line: A break in the CCND1 gene was not found in 3 cases with CD5-MCL.The prognoses of blastoid and polymorphic subtypes are poor.Special subtypes should be classified during diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Key Laboratory of Cancer Translational Medicine of Fujian, Teaching Hospital of Fujian Medical University, Fujian Tumor Hospital, Fuzhou 350014, China.

ABSTRACT

Objective: This study aims to explore the clinicopathologic features of 112 patients with mantle cell lymphoma (MCL).

Methods: Data from 112 MCL cases were collected, and immunohistochemical assay was conducted. Fluorescence in situ hybridization (FISH) detected a break in the CCND1 gene. The t-test was used in the statistical analysis.

Results: All tumor cells in the 112 cases expressed B cell-related antigen, including 1 blastoid subtype and 1 polymorphic subtype. Among all cases, 106 expressed CD5 and 104 expressed cyclin D1. A break in the CCND1 gene was not found in 3 cases with CD5-MCL. IgH/CCND1 polyploid was observed in 2 classic cases.

Conclusion: MCL is a type of special immunophenotypic B-cell lymphoma. The prognoses of blastoid and polymorphic subtypes are poor. Special subtypes should be classified during diagnosis.

No MeSH data available.


Related in: MedlinePlus