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Lymphangiosarcoma with systemic metastases in a Japanese domestic cat.

Thongtharb A, Chambers JK, Uchida K, Watanabe K, Takahashi A, Mochizuki M, Nishimura R, Nakayama H - J. Vet. Med. Sci. (2014)

Bottom Line: Microscopically, neoplastic tissues were observed in the dermis and subcutis of the trunk, lung, mediastinal lymph nodes, diaphragm, omentum and mesentery.The tumor cells were spindle to polygonal-shaped with nuclear pleomorphism aligning along pre-existing collagen bundles and forming irregular vascular channels in which the erythrocytes were rarely observed.These cells were immunopositive for vimentin, von Willebrand factor and CD31.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.

ABSTRACT
A 4-year-2-month-old female Japanese domestic cat was diagnosed with lymphangiosarcoma through tissue biopsy of an amputated leg. Two months later, the cat was euthanized, and postmortem findings revealed edema, and bruising at the caudal region of the trunk, pulmonary hemorrhage, pulmonary nodules and mediastinal lymphadenopathy. Microscopically, neoplastic tissues were observed in the dermis and subcutis of the trunk, lung, mediastinal lymph nodes, diaphragm, omentum and mesentery. The tumor cells were spindle to polygonal-shaped with nuclear pleomorphism aligning along pre-existing collagen bundles and forming irregular vascular channels in which the erythrocytes were rarely observed. These cells were immunopositive for vimentin, von Willebrand factor and CD31. Based on the histopathological and immunohistochemical features, the neoplasia was diagnosed as lymphangiosarcoma with systemic metastases.

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Cat. Metastatic lymphangiosarcoma. Plump spindle-shaped tumor cells formed irregularvascular channels. Dermis and subcutis of skin from the right hindlimb (a), ventralabdomen (b), omentum (c), mesentery (d), lung (e) and mediastinal lymph nodes (f). HE.The tumor cells were immunopositive for vimentin (g), vWF (h) and CD31 (i). DABchromogen, hematoxylin counterstain. Scale bar=100 µm.
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fig_003: Cat. Metastatic lymphangiosarcoma. Plump spindle-shaped tumor cells formed irregularvascular channels. Dermis and subcutis of skin from the right hindlimb (a), ventralabdomen (b), omentum (c), mesentery (d), lung (e) and mediastinal lymph nodes (f). HE.The tumor cells were immunopositive for vimentin (g), vWF (h) and CD31 (i). DABchromogen, hematoxylin counterstain. Scale bar=100 µm.

Mentions: Poorly differentiated tumor cells were invading the dermis and subcutis in the ventralabdomen and right hindlimb. The tumor cells were characterized by spindle-shaped eosinophilicto amphophilic cytoplasm with an indistinct border. Their nuclei were concentric and ovoid toelongate-shaped with prominent nucleoli. The tumor cells were aligned along pre-existingcollagen bundles and formed irregular vascular channels in which erythrocytes were rarelyobserved (Fig. 3a and3bFig. 3.


Lymphangiosarcoma with systemic metastases in a Japanese domestic cat.

Thongtharb A, Chambers JK, Uchida K, Watanabe K, Takahashi A, Mochizuki M, Nishimura R, Nakayama H - J. Vet. Med. Sci. (2014)

Cat. Metastatic lymphangiosarcoma. Plump spindle-shaped tumor cells formed irregularvascular channels. Dermis and subcutis of skin from the right hindlimb (a), ventralabdomen (b), omentum (c), mesentery (d), lung (e) and mediastinal lymph nodes (f). HE.The tumor cells were immunopositive for vimentin (g), vWF (h) and CD31 (i). DABchromogen, hematoxylin counterstain. Scale bar=100 µm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383788&req=5

fig_003: Cat. Metastatic lymphangiosarcoma. Plump spindle-shaped tumor cells formed irregularvascular channels. Dermis and subcutis of skin from the right hindlimb (a), ventralabdomen (b), omentum (c), mesentery (d), lung (e) and mediastinal lymph nodes (f). HE.The tumor cells were immunopositive for vimentin (g), vWF (h) and CD31 (i). DABchromogen, hematoxylin counterstain. Scale bar=100 µm.
Mentions: Poorly differentiated tumor cells were invading the dermis and subcutis in the ventralabdomen and right hindlimb. The tumor cells were characterized by spindle-shaped eosinophilicto amphophilic cytoplasm with an indistinct border. Their nuclei were concentric and ovoid toelongate-shaped with prominent nucleoli. The tumor cells were aligned along pre-existingcollagen bundles and formed irregular vascular channels in which erythrocytes were rarelyobserved (Fig. 3a and3bFig. 3.

Bottom Line: Microscopically, neoplastic tissues were observed in the dermis and subcutis of the trunk, lung, mediastinal lymph nodes, diaphragm, omentum and mesentery.The tumor cells were spindle to polygonal-shaped with nuclear pleomorphism aligning along pre-existing collagen bundles and forming irregular vascular channels in which the erythrocytes were rarely observed.These cells were immunopositive for vimentin, von Willebrand factor and CD31.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.

ABSTRACT
A 4-year-2-month-old female Japanese domestic cat was diagnosed with lymphangiosarcoma through tissue biopsy of an amputated leg. Two months later, the cat was euthanized, and postmortem findings revealed edema, and bruising at the caudal region of the trunk, pulmonary hemorrhage, pulmonary nodules and mediastinal lymphadenopathy. Microscopically, neoplastic tissues were observed in the dermis and subcutis of the trunk, lung, mediastinal lymph nodes, diaphragm, omentum and mesentery. The tumor cells were spindle to polygonal-shaped with nuclear pleomorphism aligning along pre-existing collagen bundles and forming irregular vascular channels in which the erythrocytes were rarely observed. These cells were immunopositive for vimentin, von Willebrand factor and CD31. Based on the histopathological and immunohistochemical features, the neoplasia was diagnosed as lymphangiosarcoma with systemic metastases.

Show MeSH
Related in: MedlinePlus