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Lymphangiosarcoma with systemic metastases in a Japanese domestic cat.

Thongtharb A, Chambers JK, Uchida K, Watanabe K, Takahashi A, Mochizuki M, Nishimura R, Nakayama H - J. Vet. Med. Sci. (2014)

Bottom Line: Microscopically, neoplastic tissues were observed in the dermis and subcutis of the trunk, lung, mediastinal lymph nodes, diaphragm, omentum and mesentery.The tumor cells were spindle to polygonal-shaped with nuclear pleomorphism aligning along pre-existing collagen bundles and forming irregular vascular channels in which the erythrocytes were rarely observed.These cells were immunopositive for vimentin, von Willebrand factor and CD31.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.

ABSTRACT
A 4-year-2-month-old female Japanese domestic cat was diagnosed with lymphangiosarcoma through tissue biopsy of an amputated leg. Two months later, the cat was euthanized, and postmortem findings revealed edema, and bruising at the caudal region of the trunk, pulmonary hemorrhage, pulmonary nodules and mediastinal lymphadenopathy. Microscopically, neoplastic tissues were observed in the dermis and subcutis of the trunk, lung, mediastinal lymph nodes, diaphragm, omentum and mesentery. The tumor cells were spindle to polygonal-shaped with nuclear pleomorphism aligning along pre-existing collagen bundles and forming irregular vascular channels in which the erythrocytes were rarely observed. These cells were immunopositive for vimentin, von Willebrand factor and CD31. Based on the histopathological and immunohistochemical features, the neoplasia was diagnosed as lymphangiosarcoma with systemic metastases.

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Gross findings. Cat. Metastatic lymphangiosarcoma. The right thigh was markedlyedematous with bruising (a and b). Hemorrhagic areas (arrowhead) as well as multiplenodules (arrow) were scattered throughout the entire lobes of the lung (c). Scale bar=1cm.
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fig_002: Gross findings. Cat. Metastatic lymphangiosarcoma. The right thigh was markedlyedematous with bruising (a and b). Hemorrhagic areas (arrowhead) as well as multiplenodules (arrow) were scattered throughout the entire lobes of the lung (c). Scale bar=1cm.

Mentions: Gross examination revealed diffuse edema with bruising in the subcutaneous tissue of theabdomen and right hindlimb (Fig. 2a and 2bFig. 2.


Lymphangiosarcoma with systemic metastases in a Japanese domestic cat.

Thongtharb A, Chambers JK, Uchida K, Watanabe K, Takahashi A, Mochizuki M, Nishimura R, Nakayama H - J. Vet. Med. Sci. (2014)

Gross findings. Cat. Metastatic lymphangiosarcoma. The right thigh was markedlyedematous with bruising (a and b). Hemorrhagic areas (arrowhead) as well as multiplenodules (arrow) were scattered throughout the entire lobes of the lung (c). Scale bar=1cm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383788&req=5

fig_002: Gross findings. Cat. Metastatic lymphangiosarcoma. The right thigh was markedlyedematous with bruising (a and b). Hemorrhagic areas (arrowhead) as well as multiplenodules (arrow) were scattered throughout the entire lobes of the lung (c). Scale bar=1cm.
Mentions: Gross examination revealed diffuse edema with bruising in the subcutaneous tissue of theabdomen and right hindlimb (Fig. 2a and 2bFig. 2.

Bottom Line: Microscopically, neoplastic tissues were observed in the dermis and subcutis of the trunk, lung, mediastinal lymph nodes, diaphragm, omentum and mesentery.The tumor cells were spindle to polygonal-shaped with nuclear pleomorphism aligning along pre-existing collagen bundles and forming irregular vascular channels in which the erythrocytes were rarely observed.These cells were immunopositive for vimentin, von Willebrand factor and CD31.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.

ABSTRACT
A 4-year-2-month-old female Japanese domestic cat was diagnosed with lymphangiosarcoma through tissue biopsy of an amputated leg. Two months later, the cat was euthanized, and postmortem findings revealed edema, and bruising at the caudal region of the trunk, pulmonary hemorrhage, pulmonary nodules and mediastinal lymphadenopathy. Microscopically, neoplastic tissues were observed in the dermis and subcutis of the trunk, lung, mediastinal lymph nodes, diaphragm, omentum and mesentery. The tumor cells were spindle to polygonal-shaped with nuclear pleomorphism aligning along pre-existing collagen bundles and forming irregular vascular channels in which the erythrocytes were rarely observed. These cells were immunopositive for vimentin, von Willebrand factor and CD31. Based on the histopathological and immunohistochemical features, the neoplasia was diagnosed as lymphangiosarcoma with systemic metastases.

Show MeSH
Related in: MedlinePlus