Limits...
Lymphangiosarcoma with systemic metastases in a Japanese domestic cat.

Thongtharb A, Chambers JK, Uchida K, Watanabe K, Takahashi A, Mochizuki M, Nishimura R, Nakayama H - J. Vet. Med. Sci. (2014)

Bottom Line: Microscopically, neoplastic tissues were observed in the dermis and subcutis of the trunk, lung, mediastinal lymph nodes, diaphragm, omentum and mesentery.The tumor cells were spindle to polygonal-shaped with nuclear pleomorphism aligning along pre-existing collagen bundles and forming irregular vascular channels in which the erythrocytes were rarely observed.These cells were immunopositive for vimentin, von Willebrand factor and CD31.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.

ABSTRACT
A 4-year-2-month-old female Japanese domestic cat was diagnosed with lymphangiosarcoma through tissue biopsy of an amputated leg. Two months later, the cat was euthanized, and postmortem findings revealed edema, and bruising at the caudal region of the trunk, pulmonary hemorrhage, pulmonary nodules and mediastinal lymphadenopathy. Microscopically, neoplastic tissues were observed in the dermis and subcutis of the trunk, lung, mediastinal lymph nodes, diaphragm, omentum and mesentery. The tumor cells were spindle to polygonal-shaped with nuclear pleomorphism aligning along pre-existing collagen bundles and forming irregular vascular channels in which the erythrocytes were rarely observed. These cells were immunopositive for vimentin, von Willebrand factor and CD31. Based on the histopathological and immunohistochemical features, the neoplasia was diagnosed as lymphangiosarcoma with systemic metastases.

Show MeSH

Related in: MedlinePlus

Hindlimbs. Cat. Lymphangiosarcoma. A radiological examination (a) revealed osteolyticchanges (arrowhead) and soft tissue swelling (arrows) at the left (L) hindlimb whencompared to the contralateral limb (R). Microscopically, the tumor cells formedirregular vascular channels (asterisks) in which erythrocytes were rarely observed. Mildinfiltration of lymphocytes was also noted in the interstitium. HE (b). Scale bar=200µm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4383788&req=5

fig_001: Hindlimbs. Cat. Lymphangiosarcoma. A radiological examination (a) revealed osteolyticchanges (arrowhead) and soft tissue swelling (arrows) at the left (L) hindlimb whencompared to the contralateral limb (R). Microscopically, the tumor cells formedirregular vascular channels (asterisks) in which erythrocytes were rarely observed. Mildinfiltration of lymphocytes was also noted in the interstitium. HE (b). Scale bar=200µm.

Mentions: A 4-year-2-month-old female Japanese domestic cat was presented to the Veterinary MedicalCenter, The University of Tokyo, with a history of hemorrhagic discharge at the left hindlimband non-weight bearing. The results of a radiographic examination revealed an osteolyticlesion together with swelling of surrounding tissues throughout the affected leg, particularlyat the calcaneus (Fig. 1aFig. 1.


Lymphangiosarcoma with systemic metastases in a Japanese domestic cat.

Thongtharb A, Chambers JK, Uchida K, Watanabe K, Takahashi A, Mochizuki M, Nishimura R, Nakayama H - J. Vet. Med. Sci. (2014)

Hindlimbs. Cat. Lymphangiosarcoma. A radiological examination (a) revealed osteolyticchanges (arrowhead) and soft tissue swelling (arrows) at the left (L) hindlimb whencompared to the contralateral limb (R). Microscopically, the tumor cells formedirregular vascular channels (asterisks) in which erythrocytes were rarely observed. Mildinfiltration of lymphocytes was also noted in the interstitium. HE (b). Scale bar=200µm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383788&req=5

fig_001: Hindlimbs. Cat. Lymphangiosarcoma. A radiological examination (a) revealed osteolyticchanges (arrowhead) and soft tissue swelling (arrows) at the left (L) hindlimb whencompared to the contralateral limb (R). Microscopically, the tumor cells formedirregular vascular channels (asterisks) in which erythrocytes were rarely observed. Mildinfiltration of lymphocytes was also noted in the interstitium. HE (b). Scale bar=200µm.
Mentions: A 4-year-2-month-old female Japanese domestic cat was presented to the Veterinary MedicalCenter, The University of Tokyo, with a history of hemorrhagic discharge at the left hindlimband non-weight bearing. The results of a radiographic examination revealed an osteolyticlesion together with swelling of surrounding tissues throughout the affected leg, particularlyat the calcaneus (Fig. 1aFig. 1.

Bottom Line: Microscopically, neoplastic tissues were observed in the dermis and subcutis of the trunk, lung, mediastinal lymph nodes, diaphragm, omentum and mesentery.The tumor cells were spindle to polygonal-shaped with nuclear pleomorphism aligning along pre-existing collagen bundles and forming irregular vascular channels in which the erythrocytes were rarely observed.These cells were immunopositive for vimentin, von Willebrand factor and CD31.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.

ABSTRACT
A 4-year-2-month-old female Japanese domestic cat was diagnosed with lymphangiosarcoma through tissue biopsy of an amputated leg. Two months later, the cat was euthanized, and postmortem findings revealed edema, and bruising at the caudal region of the trunk, pulmonary hemorrhage, pulmonary nodules and mediastinal lymphadenopathy. Microscopically, neoplastic tissues were observed in the dermis and subcutis of the trunk, lung, mediastinal lymph nodes, diaphragm, omentum and mesentery. The tumor cells were spindle to polygonal-shaped with nuclear pleomorphism aligning along pre-existing collagen bundles and forming irregular vascular channels in which the erythrocytes were rarely observed. These cells were immunopositive for vimentin, von Willebrand factor and CD31. Based on the histopathological and immunohistochemical features, the neoplasia was diagnosed as lymphangiosarcoma with systemic metastases.

Show MeSH
Related in: MedlinePlus