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Genetic analysis of litter size in mice.

Suto J - J. Vet. Med. Sci. (2014)

Bottom Line: These results suggested that both litter size and number of stillbirth were heritable traits, although they were controlled by distinct genes.The RR allele was associated with reduced litter size and increased stillbirth at all QTLs.Therefore, RR mothers were observed to have reduced prolificacy in this particular genetic cross.

View Article: PubMed Central - PubMed

Affiliation: Agrogenomics Research Center, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8634, Japan.

ABSTRACT
We performed quantitative trait locus (QTL) mapping analysis for litter size (total number of pups born and/or number of pups born alive) in 255 backcross mice derived from C57BL/6J and RR/Sgn inbred mice. We identified one significant QTL on chromosome 7 and 4 suggestive QTLs on chromosomes 3, 5, 10 and 13. In addition, two suggestive QTLs were identified on chromosomes 1 and 4 for the number of stillbirth. These results suggested that both litter size and number of stillbirth were heritable traits, although they were controlled by distinct genes. The RR allele was associated with reduced litter size and increased stillbirth at all QTLs. Therefore, RR mothers were observed to have reduced prolificacy in this particular genetic cross.

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Comparison of LOD score plots for litter size on chromosome 7 between two independentQTL mapping analyses. (Left) LOD score plots for TNB in (B6 × RR) × RR BC mice. Thehorizontal dashed lines indicate significant and suggestive threshold LOD scoresdetermined from 1,000 permutations. (Right) LOD score plots for NBA in KK × RRF2 mice. Solid and broken lines indicate the results of nonparametric andparametric methods, respectively. Localization of several microsatellite markers isshown on the X-axis.
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fig_002: Comparison of LOD score plots for litter size on chromosome 7 between two independentQTL mapping analyses. (Left) LOD score plots for TNB in (B6 × RR) × RR BC mice. Thehorizontal dashed lines indicate significant and suggestive threshold LOD scoresdetermined from 1,000 permutations. (Right) LOD score plots for NBA in KK × RRF2 mice. Solid and broken lines indicate the results of nonparametric andparametric methods, respectively. Localization of several microsatellite markers isshown on the X-axis.

Mentions: (A) A histogram showing the distribution of total number of pups born (TNB). (B)Genome-wide LOD score plots for TNB (solid lines) and NBA (broken lines). The horizontaldashed lines indicate significant and suggestive threshold LOD scores determined from1,000 permutations. For TNB, threshold LOD scores for significant and suggestivelinkages were 2.51 and 1.31 for autosomes and 2.65 and 1.42 for the X chromosome,respectively. For NBA, threshold LOD scores for significant and suggestive linkages were2.62 and 1.33 for autosomes and 2.56 and 1.40 for the X chromosome, respectively. (C)Allele effects of Litter size QTL 1 (Lsq1; D7Mit228)on TNB. Squares indicate the mean TNB, and error bars indicate standard errors.


Genetic analysis of litter size in mice.

Suto J - J. Vet. Med. Sci. (2014)

Comparison of LOD score plots for litter size on chromosome 7 between two independentQTL mapping analyses. (Left) LOD score plots for TNB in (B6 × RR) × RR BC mice. Thehorizontal dashed lines indicate significant and suggestive threshold LOD scoresdetermined from 1,000 permutations. (Right) LOD score plots for NBA in KK × RRF2 mice. Solid and broken lines indicate the results of nonparametric andparametric methods, respectively. Localization of several microsatellite markers isshown on the X-axis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383785&req=5

fig_002: Comparison of LOD score plots for litter size on chromosome 7 between two independentQTL mapping analyses. (Left) LOD score plots for TNB in (B6 × RR) × RR BC mice. Thehorizontal dashed lines indicate significant and suggestive threshold LOD scoresdetermined from 1,000 permutations. (Right) LOD score plots for NBA in KK × RRF2 mice. Solid and broken lines indicate the results of nonparametric andparametric methods, respectively. Localization of several microsatellite markers isshown on the X-axis.
Mentions: (A) A histogram showing the distribution of total number of pups born (TNB). (B)Genome-wide LOD score plots for TNB (solid lines) and NBA (broken lines). The horizontaldashed lines indicate significant and suggestive threshold LOD scores determined from1,000 permutations. For TNB, threshold LOD scores for significant and suggestivelinkages were 2.51 and 1.31 for autosomes and 2.65 and 1.42 for the X chromosome,respectively. For NBA, threshold LOD scores for significant and suggestive linkages were2.62 and 1.33 for autosomes and 2.56 and 1.40 for the X chromosome, respectively. (C)Allele effects of Litter size QTL 1 (Lsq1; D7Mit228)on TNB. Squares indicate the mean TNB, and error bars indicate standard errors.

Bottom Line: These results suggested that both litter size and number of stillbirth were heritable traits, although they were controlled by distinct genes.The RR allele was associated with reduced litter size and increased stillbirth at all QTLs.Therefore, RR mothers were observed to have reduced prolificacy in this particular genetic cross.

View Article: PubMed Central - PubMed

Affiliation: Agrogenomics Research Center, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8634, Japan.

ABSTRACT
We performed quantitative trait locus (QTL) mapping analysis for litter size (total number of pups born and/or number of pups born alive) in 255 backcross mice derived from C57BL/6J and RR/Sgn inbred mice. We identified one significant QTL on chromosome 7 and 4 suggestive QTLs on chromosomes 3, 5, 10 and 13. In addition, two suggestive QTLs were identified on chromosomes 1 and 4 for the number of stillbirth. These results suggested that both litter size and number of stillbirth were heritable traits, although they were controlled by distinct genes. The RR allele was associated with reduced litter size and increased stillbirth at all QTLs. Therefore, RR mothers were observed to have reduced prolificacy in this particular genetic cross.

Show MeSH