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Pathogenicity of border disease virus FNK2012-1 strain isolated from a pig in the natural host, sheep.

Tamura T, Mine J, Torii S, Fujimoto Y, Okamatsu M, Sakoda Y - J. Vet. Med. Sci. (2014)

Bottom Line: The inoculated sheep showed clinical symptoms and transient viremia.Seroconversion was observed in the inoculated sheep.Therefore, surveillance of border disease in Japan is necessary among both the swine and ruminant populations.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.

ABSTRACT
A first isolation of border disease virus (BDV) in Japan was from a pig on a farm without keeping any ruminants. Our previous study showed that this BDV, termed the FNK2012-1 strain, replicated inefficiently in swine-derived cells compared with those of ruminant origin. Pigs inoculated with this virus showed neither clinical symptoms nor viremia. In this study, we evaluated the pathogenicity of the FNK2012-1 strain in sheep, its natural host. The inoculated sheep showed clinical symptoms and transient viremia. Seroconversion was observed in the inoculated sheep. These results suggest that the FNK2012-1 strain was introduced from sheep and has not yet adapted to swine. Therefore, surveillance of border disease in Japan is necessary among both the swine and ruminant populations.

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Related in: MedlinePlus

Body temperature of lambs before and after inoculation with border disease virusFNK2012-1 strain. Four lambs were intranasally inoculated with the FNK2012-1 strain.Rectal temperature was monitored daily beginning 3 days before inoculation. A bodytemperature above 40.0°C was considered fever. “†” indicates the lambs were euthanizedat that time.
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fig_001: Body temperature of lambs before and after inoculation with border disease virusFNK2012-1 strain. Four lambs were intranasally inoculated with the FNK2012-1 strain.Rectal temperature was monitored daily beginning 3 days before inoculation. A bodytemperature above 40.0°C was considered fever. “†” indicates the lambs were euthanizedat that time.

Mentions: Infection of lambs with the FNK2012-1 strain resulted in mild clinical symptoms in 3 out ofthe 4 lambs: nasal discharge (#2 and #3) and depression (#3 and #4). Fever was observed in 3of the 4 lambs within 10 days pi (Fig.1Fig. 1.


Pathogenicity of border disease virus FNK2012-1 strain isolated from a pig in the natural host, sheep.

Tamura T, Mine J, Torii S, Fujimoto Y, Okamatsu M, Sakoda Y - J. Vet. Med. Sci. (2014)

Body temperature of lambs before and after inoculation with border disease virusFNK2012-1 strain. Four lambs were intranasally inoculated with the FNK2012-1 strain.Rectal temperature was monitored daily beginning 3 days before inoculation. A bodytemperature above 40.0°C was considered fever. “†” indicates the lambs were euthanizedat that time.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383782&req=5

fig_001: Body temperature of lambs before and after inoculation with border disease virusFNK2012-1 strain. Four lambs were intranasally inoculated with the FNK2012-1 strain.Rectal temperature was monitored daily beginning 3 days before inoculation. A bodytemperature above 40.0°C was considered fever. “†” indicates the lambs were euthanizedat that time.
Mentions: Infection of lambs with the FNK2012-1 strain resulted in mild clinical symptoms in 3 out ofthe 4 lambs: nasal discharge (#2 and #3) and depression (#3 and #4). Fever was observed in 3of the 4 lambs within 10 days pi (Fig.1Fig. 1.

Bottom Line: The inoculated sheep showed clinical symptoms and transient viremia.Seroconversion was observed in the inoculated sheep.Therefore, surveillance of border disease in Japan is necessary among both the swine and ruminant populations.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.

ABSTRACT
A first isolation of border disease virus (BDV) in Japan was from a pig on a farm without keeping any ruminants. Our previous study showed that this BDV, termed the FNK2012-1 strain, replicated inefficiently in swine-derived cells compared with those of ruminant origin. Pigs inoculated with this virus showed neither clinical symptoms nor viremia. In this study, we evaluated the pathogenicity of the FNK2012-1 strain in sheep, its natural host. The inoculated sheep showed clinical symptoms and transient viremia. Seroconversion was observed in the inoculated sheep. These results suggest that the FNK2012-1 strain was introduced from sheep and has not yet adapted to swine. Therefore, surveillance of border disease in Japan is necessary among both the swine and ruminant populations.

Show MeSH
Related in: MedlinePlus