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Cardiovascular effects of total intravenous anesthesia using ketamine-medetomidine-propofol (KMP-TIVA) in horses undergoing surgery.

Umar MA, Fukui S, Kawase K, Itami T, Yamashita K - J. Vet. Med. Sci. (2014)

Bottom Line: Cardiovascular effects of total intravenous anesthesia using ketamine-medetomidine-propofol drug combination (KMP-TIVA) were determined in 5 Thoroughbred horses undergoing surgery.Cardiovascular measurements during surgery remained within clinically acceptable ranges in the horses (heart rate: 33 to 37 beats/min, mean arterial blood pressure: 111 to 119 mmHg, cardiac index: 48 to 53 ml/kg/min, stroke volume: 650 to 800 ml/beat and systemic vascular resistance: 311 to 398 dynes/sec/cm(5)).The propofol Cpl declined rapidly after the cessation of propofol infusion and was significantly lower at 10 min (4.5 ± 1.5 µg/ml), extubation (4.0 ± 1.2 µg/ml) and standing (2.4 ± 0.9 µg/ml) compared with the Cpl at the end of propofol administration (11.4 ± 2.7 µg/ml).

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Surgery and Theriogenology, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Borno State, Nigeria.

ABSTRACT
Cardiovascular effects of total intravenous anesthesia using ketamine-medetomidine-propofol drug combination (KMP-TIVA) were determined in 5 Thoroughbred horses undergoing surgery. The horses were anesthetized with intravenous administration (IV) of ketamine (2.5 mg/kg) and midazolam (0.04 mg/kg) following premedication with medetomidne (5 µg/kg, IV) and artificially ventilated. Surgical anesthesia was maintained by controlling propofol infusion rate (initially 0.20 mg/kg/min following an IV loading dose of 0.5 mg/kg) and constant rate infusions of ketamine (1 mg/kg/hr) and medetomidine (1.25 µg/kg/hr). The horses were anesthetized for 175 ± 14 min (range from 160 to 197 min). Propofol infusion rates ranged from 0.13 to 0.17 mg/kg/min, and plasma concentration (Cpl) of propofol ranged from 11.4 to 13.3 µg/ml during surgery. Cardiovascular measurements during surgery remained within clinically acceptable ranges in the horses (heart rate: 33 to 37 beats/min, mean arterial blood pressure: 111 to 119 mmHg, cardiac index: 48 to 53 ml/kg/min, stroke volume: 650 to 800 ml/beat and systemic vascular resistance: 311 to 398 dynes/sec/cm(5)). The propofol Cpl declined rapidly after the cessation of propofol infusion and was significantly lower at 10 min (4.5 ± 1.5 µg/ml), extubation (4.0 ± 1.2 µg/ml) and standing (2.4 ± 0.9 µg/ml) compared with the Cpl at the end of propofol administration (11.4 ± 2.7 µg/ml). All the horses recovered uneventfully and stood at 74 ± 28 min after the cessation of anesthesia. KMP-TIVA provided satisfactory quality and control of anesthesia with minimum cardiovascular depression in horses undergoing surgery.

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Propofol infusion rates and plasma concentration (Cpl) in 5 horses undergoingKMP-TIVA. Closed circles showed mean value of propofol infusion rates from 5 horses.Closed squares and error bars showed mean value of Cpl and its standard deviation,respectively. Values significantly (**P<0.01) lower than the Cplof propofol at the end of operation. Before skin incision (just before skin incision);30 min (30 min after beginning surgery); 60 min (60 min after beginning surgery);Ope-end (at the end of operation); Prop.-stop (at the end of propofol infusion); 10min (10 min after cessation of propofol administration), Ext (just after extubation);Stand (just after the horses stood).
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fig_002: Propofol infusion rates and plasma concentration (Cpl) in 5 horses undergoingKMP-TIVA. Closed circles showed mean value of propofol infusion rates from 5 horses.Closed squares and error bars showed mean value of Cpl and its standard deviation,respectively. Values significantly (**P<0.01) lower than the Cplof propofol at the end of operation. Before skin incision (just before skin incision);30 min (30 min after beginning surgery); 60 min (60 min after beginning surgery);Ope-end (at the end of operation); Prop.-stop (at the end of propofol infusion); 10min (10 min after cessation of propofol administration), Ext (just after extubation);Stand (just after the horses stood).

Mentions: Propofol infusion rate and plasma concentration: The CRI of propofolranged from 0.17 ± 0.01 mg/kg/min before skin incision to 0.13 ± 0.01 mg/kg/min at the timeof cessation of propofol infusion (Fig. 2Fig. 2.


Cardiovascular effects of total intravenous anesthesia using ketamine-medetomidine-propofol (KMP-TIVA) in horses undergoing surgery.

Umar MA, Fukui S, Kawase K, Itami T, Yamashita K - J. Vet. Med. Sci. (2014)

Propofol infusion rates and plasma concentration (Cpl) in 5 horses undergoingKMP-TIVA. Closed circles showed mean value of propofol infusion rates from 5 horses.Closed squares and error bars showed mean value of Cpl and its standard deviation,respectively. Values significantly (**P<0.01) lower than the Cplof propofol at the end of operation. Before skin incision (just before skin incision);30 min (30 min after beginning surgery); 60 min (60 min after beginning surgery);Ope-end (at the end of operation); Prop.-stop (at the end of propofol infusion); 10min (10 min after cessation of propofol administration), Ext (just after extubation);Stand (just after the horses stood).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383773&req=5

fig_002: Propofol infusion rates and plasma concentration (Cpl) in 5 horses undergoingKMP-TIVA. Closed circles showed mean value of propofol infusion rates from 5 horses.Closed squares and error bars showed mean value of Cpl and its standard deviation,respectively. Values significantly (**P<0.01) lower than the Cplof propofol at the end of operation. Before skin incision (just before skin incision);30 min (30 min after beginning surgery); 60 min (60 min after beginning surgery);Ope-end (at the end of operation); Prop.-stop (at the end of propofol infusion); 10min (10 min after cessation of propofol administration), Ext (just after extubation);Stand (just after the horses stood).
Mentions: Propofol infusion rate and plasma concentration: The CRI of propofolranged from 0.17 ± 0.01 mg/kg/min before skin incision to 0.13 ± 0.01 mg/kg/min at the timeof cessation of propofol infusion (Fig. 2Fig. 2.

Bottom Line: Cardiovascular effects of total intravenous anesthesia using ketamine-medetomidine-propofol drug combination (KMP-TIVA) were determined in 5 Thoroughbred horses undergoing surgery.Cardiovascular measurements during surgery remained within clinically acceptable ranges in the horses (heart rate: 33 to 37 beats/min, mean arterial blood pressure: 111 to 119 mmHg, cardiac index: 48 to 53 ml/kg/min, stroke volume: 650 to 800 ml/beat and systemic vascular resistance: 311 to 398 dynes/sec/cm(5)).The propofol Cpl declined rapidly after the cessation of propofol infusion and was significantly lower at 10 min (4.5 ± 1.5 µg/ml), extubation (4.0 ± 1.2 µg/ml) and standing (2.4 ± 0.9 µg/ml) compared with the Cpl at the end of propofol administration (11.4 ± 2.7 µg/ml).

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Surgery and Theriogenology, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Borno State, Nigeria.

ABSTRACT
Cardiovascular effects of total intravenous anesthesia using ketamine-medetomidine-propofol drug combination (KMP-TIVA) were determined in 5 Thoroughbred horses undergoing surgery. The horses were anesthetized with intravenous administration (IV) of ketamine (2.5 mg/kg) and midazolam (0.04 mg/kg) following premedication with medetomidne (5 µg/kg, IV) and artificially ventilated. Surgical anesthesia was maintained by controlling propofol infusion rate (initially 0.20 mg/kg/min following an IV loading dose of 0.5 mg/kg) and constant rate infusions of ketamine (1 mg/kg/hr) and medetomidine (1.25 µg/kg/hr). The horses were anesthetized for 175 ± 14 min (range from 160 to 197 min). Propofol infusion rates ranged from 0.13 to 0.17 mg/kg/min, and plasma concentration (Cpl) of propofol ranged from 11.4 to 13.3 µg/ml during surgery. Cardiovascular measurements during surgery remained within clinically acceptable ranges in the horses (heart rate: 33 to 37 beats/min, mean arterial blood pressure: 111 to 119 mmHg, cardiac index: 48 to 53 ml/kg/min, stroke volume: 650 to 800 ml/beat and systemic vascular resistance: 311 to 398 dynes/sec/cm(5)). The propofol Cpl declined rapidly after the cessation of propofol infusion and was significantly lower at 10 min (4.5 ± 1.5 µg/ml), extubation (4.0 ± 1.2 µg/ml) and standing (2.4 ± 0.9 µg/ml) compared with the Cpl at the end of propofol administration (11.4 ± 2.7 µg/ml). All the horses recovered uneventfully and stood at 74 ± 28 min after the cessation of anesthesia. KMP-TIVA provided satisfactory quality and control of anesthesia with minimum cardiovascular depression in horses undergoing surgery.

Show MeSH
Related in: MedlinePlus