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Cardiovascular effects of total intravenous anesthesia using ketamine-medetomidine-propofol (KMP-TIVA) in horses undergoing surgery.

Umar MA, Fukui S, Kawase K, Itami T, Yamashita K - J. Vet. Med. Sci. (2014)

Bottom Line: Cardiovascular effects of total intravenous anesthesia using ketamine-medetomidine-propofol drug combination (KMP-TIVA) were determined in 5 Thoroughbred horses undergoing surgery.Cardiovascular measurements during surgery remained within clinically acceptable ranges in the horses (heart rate: 33 to 37 beats/min, mean arterial blood pressure: 111 to 119 mmHg, cardiac index: 48 to 53 ml/kg/min, stroke volume: 650 to 800 ml/beat and systemic vascular resistance: 311 to 398 dynes/sec/cm(5)).The propofol Cpl declined rapidly after the cessation of propofol infusion and was significantly lower at 10 min (4.5 ± 1.5 µg/ml), extubation (4.0 ± 1.2 µg/ml) and standing (2.4 ± 0.9 µg/ml) compared with the Cpl at the end of propofol administration (11.4 ± 2.7 µg/ml).

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Surgery and Theriogenology, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Borno State, Nigeria.

ABSTRACT
Cardiovascular effects of total intravenous anesthesia using ketamine-medetomidine-propofol drug combination (KMP-TIVA) were determined in 5 Thoroughbred horses undergoing surgery. The horses were anesthetized with intravenous administration (IV) of ketamine (2.5 mg/kg) and midazolam (0.04 mg/kg) following premedication with medetomidne (5 µg/kg, IV) and artificially ventilated. Surgical anesthesia was maintained by controlling propofol infusion rate (initially 0.20 mg/kg/min following an IV loading dose of 0.5 mg/kg) and constant rate infusions of ketamine (1 mg/kg/hr) and medetomidine (1.25 µg/kg/hr). The horses were anesthetized for 175 ± 14 min (range from 160 to 197 min). Propofol infusion rates ranged from 0.13 to 0.17 mg/kg/min, and plasma concentration (Cpl) of propofol ranged from 11.4 to 13.3 µg/ml during surgery. Cardiovascular measurements during surgery remained within clinically acceptable ranges in the horses (heart rate: 33 to 37 beats/min, mean arterial blood pressure: 111 to 119 mmHg, cardiac index: 48 to 53 ml/kg/min, stroke volume: 650 to 800 ml/beat and systemic vascular resistance: 311 to 398 dynes/sec/cm(5)). The propofol Cpl declined rapidly after the cessation of propofol infusion and was significantly lower at 10 min (4.5 ± 1.5 µg/ml), extubation (4.0 ± 1.2 µg/ml) and standing (2.4 ± 0.9 µg/ml) compared with the Cpl at the end of propofol administration (11.4 ± 2.7 µg/ml). All the horses recovered uneventfully and stood at 74 ± 28 min after the cessation of anesthesia. KMP-TIVA provided satisfactory quality and control of anesthesia with minimum cardiovascular depression in horses undergoing surgery.

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Cardiovascular values during surgery in 5 horses undergoing KMP-TIVA. Plots and errorbars showed mean value and standard deviation from 5 horses, respectively. HR: heartrate, MABP: mean arterial blood pressure, MPAP: mean pulmonary artery pressure, MRAP:mean right atrial pressure, CO: cardiac output, CI: cardiac index, SV: stroke volume,SVR: systemic vascular resistance, Before skin incision: just before skin incision, 30min: 30 min into surgery, 60 min: 60 min into surgery, Ope-end: at the end ofoperation.
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fig_001: Cardiovascular values during surgery in 5 horses undergoing KMP-TIVA. Plots and errorbars showed mean value and standard deviation from 5 horses, respectively. HR: heartrate, MABP: mean arterial blood pressure, MPAP: mean pulmonary artery pressure, MRAP:mean right atrial pressure, CO: cardiac output, CI: cardiac index, SV: stroke volume,SVR: systemic vascular resistance, Before skin incision: just before skin incision, 30min: 30 min into surgery, 60 min: 60 min into surgery, Ope-end: at the end ofoperation.

Mentions: Cardiovascular effects: Cardiovascular parameters were stable andpreserved within normal limits for anesthetized horses (Fig. 1Fig. 1.


Cardiovascular effects of total intravenous anesthesia using ketamine-medetomidine-propofol (KMP-TIVA) in horses undergoing surgery.

Umar MA, Fukui S, Kawase K, Itami T, Yamashita K - J. Vet. Med. Sci. (2014)

Cardiovascular values during surgery in 5 horses undergoing KMP-TIVA. Plots and errorbars showed mean value and standard deviation from 5 horses, respectively. HR: heartrate, MABP: mean arterial blood pressure, MPAP: mean pulmonary artery pressure, MRAP:mean right atrial pressure, CO: cardiac output, CI: cardiac index, SV: stroke volume,SVR: systemic vascular resistance, Before skin incision: just before skin incision, 30min: 30 min into surgery, 60 min: 60 min into surgery, Ope-end: at the end ofoperation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383773&req=5

fig_001: Cardiovascular values during surgery in 5 horses undergoing KMP-TIVA. Plots and errorbars showed mean value and standard deviation from 5 horses, respectively. HR: heartrate, MABP: mean arterial blood pressure, MPAP: mean pulmonary artery pressure, MRAP:mean right atrial pressure, CO: cardiac output, CI: cardiac index, SV: stroke volume,SVR: systemic vascular resistance, Before skin incision: just before skin incision, 30min: 30 min into surgery, 60 min: 60 min into surgery, Ope-end: at the end ofoperation.
Mentions: Cardiovascular effects: Cardiovascular parameters were stable andpreserved within normal limits for anesthetized horses (Fig. 1Fig. 1.

Bottom Line: Cardiovascular effects of total intravenous anesthesia using ketamine-medetomidine-propofol drug combination (KMP-TIVA) were determined in 5 Thoroughbred horses undergoing surgery.Cardiovascular measurements during surgery remained within clinically acceptable ranges in the horses (heart rate: 33 to 37 beats/min, mean arterial blood pressure: 111 to 119 mmHg, cardiac index: 48 to 53 ml/kg/min, stroke volume: 650 to 800 ml/beat and systemic vascular resistance: 311 to 398 dynes/sec/cm(5)).The propofol Cpl declined rapidly after the cessation of propofol infusion and was significantly lower at 10 min (4.5 ± 1.5 µg/ml), extubation (4.0 ± 1.2 µg/ml) and standing (2.4 ± 0.9 µg/ml) compared with the Cpl at the end of propofol administration (11.4 ± 2.7 µg/ml).

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Surgery and Theriogenology, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Borno State, Nigeria.

ABSTRACT
Cardiovascular effects of total intravenous anesthesia using ketamine-medetomidine-propofol drug combination (KMP-TIVA) were determined in 5 Thoroughbred horses undergoing surgery. The horses were anesthetized with intravenous administration (IV) of ketamine (2.5 mg/kg) and midazolam (0.04 mg/kg) following premedication with medetomidne (5 µg/kg, IV) and artificially ventilated. Surgical anesthesia was maintained by controlling propofol infusion rate (initially 0.20 mg/kg/min following an IV loading dose of 0.5 mg/kg) and constant rate infusions of ketamine (1 mg/kg/hr) and medetomidine (1.25 µg/kg/hr). The horses were anesthetized for 175 ± 14 min (range from 160 to 197 min). Propofol infusion rates ranged from 0.13 to 0.17 mg/kg/min, and plasma concentration (Cpl) of propofol ranged from 11.4 to 13.3 µg/ml during surgery. Cardiovascular measurements during surgery remained within clinically acceptable ranges in the horses (heart rate: 33 to 37 beats/min, mean arterial blood pressure: 111 to 119 mmHg, cardiac index: 48 to 53 ml/kg/min, stroke volume: 650 to 800 ml/beat and systemic vascular resistance: 311 to 398 dynes/sec/cm(5)). The propofol Cpl declined rapidly after the cessation of propofol infusion and was significantly lower at 10 min (4.5 ± 1.5 µg/ml), extubation (4.0 ± 1.2 µg/ml) and standing (2.4 ± 0.9 µg/ml) compared with the Cpl at the end of propofol administration (11.4 ± 2.7 µg/ml). All the horses recovered uneventfully and stood at 74 ± 28 min after the cessation of anesthesia. KMP-TIVA provided satisfactory quality and control of anesthesia with minimum cardiovascular depression in horses undergoing surgery.

Show MeSH
Related in: MedlinePlus