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Effects of six months of Yoga on inflammatory serum markers prognostic of recurrence risk in breast cancer survivors.

Long Parma D, Hughes DC, Ghosh S, Li R, Treviño-Whitaker RA, Ogden SM, Ramirez AG - Springerplus (2015)

Bottom Line: Descriptive statistics, effect size (d), and dependent sample 't' tests for all outcome measures were calculated for the YE group.We found no differences between groups.Moreover, we did not see significant changes in any inflammatory marker for any group.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology and Biostatistics, Institute for Health Promotion Research, University of Texas Health Science Center at San Antonio, 7411 John Smith Drive Suite 1000, San Antonio, TX USA.

ABSTRACT
Yoga-based exercise has proven to be beneficial for practitioners, including cancer survivors. This study reports on the effect on inflammatory biological markers for 20 breast cancer survivors who participated in a six-month yoga-based (YE) exercise program. Results are compared to a comprehensive exercise (CE) program group and a comparison (C) exercise group who chose their own exercises. "Pre" and "post" assessments included measures of anthropometrics, cardiorespiratory capacity, and inflammatory markers interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factor alpha (TNFα) and C-reactive protein (CRP). Descriptive statistics, effect size (d), and dependent sample 't' tests for all outcome measures were calculated for the YE group. Significant improvements were seen in decreased % body fat, (-3.00%, d = -0.44, p = <.001) but not in cardiorespiratory capacity or in inflammatory serum markers. To compare YE outcomes with the other two groups, a one-way analysis of co-variance (ANCOVA) was used, controlling for age, BMI, cardiorespiratory capacity and serum marker baseline values. We found no differences between groups. Moreover, we did not see significant changes in any inflammatory marker for any group. Our results support the effectiveness of yoga-based exercise modified for breast cancer survivors for improving body composition. Larger studies are needed to determine if there are significant changes in inflammatory serum markers as a result of specific exercise modalities.

No MeSH data available.


Related in: MedlinePlus

Study flow diagram.
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Fig1: Study flow diagram.

Mentions: Of the 130 women who expressed interest in the study, 121 met the inclusion criteria, and 94 of those completed baseline fitness assessments (Figure 1). Informed consent was obtained with the baseline assessments conducted at a cancer treatment center in the San Antonio, Texas area. Using a minimization adaptive randomization technique, participant covariates of age, body mass index (BMI), and cardiorespiratory capacity (estimated VO2max) were used to assign 94 participants either to 1) a yoga-based exercise program (YE) group, n = 31; 2) a comprehensive, individualized exercise program (CE) group, n = 31; or, 3) a comparison group (C), in which participants performed exercises of their choice, n = 32. Of the 31 participants randomized to the YE group, 20 completed the 6-month trial and completed “post” fitness assessments. In the other two groups, a total of 11 participants dropped out, resulting in 26 participants completing the study in the CE group and the C group, respectively. There were no reported injuries in any group related to the exercise programs.Figure 1


Effects of six months of Yoga on inflammatory serum markers prognostic of recurrence risk in breast cancer survivors.

Long Parma D, Hughes DC, Ghosh S, Li R, Treviño-Whitaker RA, Ogden SM, Ramirez AG - Springerplus (2015)

Study flow diagram.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383749&req=5

Fig1: Study flow diagram.
Mentions: Of the 130 women who expressed interest in the study, 121 met the inclusion criteria, and 94 of those completed baseline fitness assessments (Figure 1). Informed consent was obtained with the baseline assessments conducted at a cancer treatment center in the San Antonio, Texas area. Using a minimization adaptive randomization technique, participant covariates of age, body mass index (BMI), and cardiorespiratory capacity (estimated VO2max) were used to assign 94 participants either to 1) a yoga-based exercise program (YE) group, n = 31; 2) a comprehensive, individualized exercise program (CE) group, n = 31; or, 3) a comparison group (C), in which participants performed exercises of their choice, n = 32. Of the 31 participants randomized to the YE group, 20 completed the 6-month trial and completed “post” fitness assessments. In the other two groups, a total of 11 participants dropped out, resulting in 26 participants completing the study in the CE group and the C group, respectively. There were no reported injuries in any group related to the exercise programs.Figure 1

Bottom Line: Descriptive statistics, effect size (d), and dependent sample 't' tests for all outcome measures were calculated for the YE group.We found no differences between groups.Moreover, we did not see significant changes in any inflammatory marker for any group.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology and Biostatistics, Institute for Health Promotion Research, University of Texas Health Science Center at San Antonio, 7411 John Smith Drive Suite 1000, San Antonio, TX USA.

ABSTRACT
Yoga-based exercise has proven to be beneficial for practitioners, including cancer survivors. This study reports on the effect on inflammatory biological markers for 20 breast cancer survivors who participated in a six-month yoga-based (YE) exercise program. Results are compared to a comprehensive exercise (CE) program group and a comparison (C) exercise group who chose their own exercises. "Pre" and "post" assessments included measures of anthropometrics, cardiorespiratory capacity, and inflammatory markers interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factor alpha (TNFα) and C-reactive protein (CRP). Descriptive statistics, effect size (d), and dependent sample 't' tests for all outcome measures were calculated for the YE group. Significant improvements were seen in decreased % body fat, (-3.00%, d = -0.44, p = <.001) but not in cardiorespiratory capacity or in inflammatory serum markers. To compare YE outcomes with the other two groups, a one-way analysis of co-variance (ANCOVA) was used, controlling for age, BMI, cardiorespiratory capacity and serum marker baseline values. We found no differences between groups. Moreover, we did not see significant changes in any inflammatory marker for any group. Our results support the effectiveness of yoga-based exercise modified for breast cancer survivors for improving body composition. Larger studies are needed to determine if there are significant changes in inflammatory serum markers as a result of specific exercise modalities.

No MeSH data available.


Related in: MedlinePlus