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Lack of multisensory integration in hemianopia: no influence of visual stimuli on aurally guided saccades to the blind hemifield.

Ten Brink AF, Nijboer TC, Bergsma DP, Barton JJ, Van der Stigchel S - PLoS ONE (2015)

Bottom Line: The superior colliculus (SC) is part of the spared pathway that is considered to be responsible for this phenomenon.In one patient with a more limited quadrantano-pia, a facilitation effect of the spatially coincident visual stimulus was observed.We conclude that our results show that multisensory integration is infrequent in the blind field of patients with hemianopia.

View Article: PubMed Central - PubMed

Affiliation: Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, The Netherlands; Brain Center Rudolf Magnus Institute of Neuroscience and Centre of Excellence for Rehabilitation Medicine, University Medical Centre Utrecht and Rehabilitation Centre De Hoogstraat, Utrecht, The Netherlands.

ABSTRACT
In patients with visual hemifield defects residual visual functions may be present, a phenomenon called blindsight. The superior colliculus (SC) is part of the spared pathway that is considered to be responsible for this phenomenon. Given that the SC processes input from different modalities and is involved in the programming of saccadic eye movements, the aim of the present study was to examine whether multimodal integration can modulate oculomotor competition in the damaged hemifield. We conducted two experiments with eight patients who had visual field defects due to lesions that affected the retinogeniculate pathway but spared the retinotectal direct SC pathway. They had to make saccades to an auditory target that was presented alone or in combination with a visual stimulus. The visual stimulus could either be spatially coincident with the auditory target (possibly enhancing the auditory target signal), or spatially disparate to the auditory target (possibly competing with the auditory tar-get signal). For each patient we compared the saccade endpoint deviation in these two bi-modal conditions with the endpoint deviation in the unimodal condition (auditory target alone). In all seven hemianopic patients, saccade accuracy was affected only by visual stimuli in the intact, but not in the blind visual field. In one patient with a more limited quadrantano-pia, a facilitation effect of the spatially coincident visual stimulus was observed. We conclude that our results show that multisensory integration is infrequent in the blind field of patients with hemianopia.

No MeSH data available.


Related in: MedlinePlus

Mean saccade latency of each patient in the three different conditions.Error bars depict standard deviations. Asterisks indicate a significant change in endpoints (* at ɑ = .005; ** at ɑ = .001). No data is displayed for the bimodal disparate condition in the blind visual field of Case 5, since target and distractor could never be in the blind quadrant together.
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pone.0122054.g005: Mean saccade latency of each patient in the three different conditions.Error bars depict standard deviations. Asterisks indicate a significant change in endpoints (* at ɑ = .005; ** at ɑ = .001). No data is displayed for the bimodal disparate condition in the blind visual field of Case 5, since target and distractor could never be in the blind quadrant together.

Mentions: There were effects of condition in the intact ipsilateral hemifield of some but not all hemianopic patients (Fig. 5). The latency was shorter in the bimodal disparate than in the unimodal condition for both Case 1 (p = .004) and Case 4 (p < .001), but not in the bimodal coincident condition. In Case 5, the latency was shorter in both bimodal conditions when compared to the unimodal condition (bimodal coincident: p < .001; bimodal disparate: p = .002). In the blind hemifields no differences were observed in any patient (all p > .05).


Lack of multisensory integration in hemianopia: no influence of visual stimuli on aurally guided saccades to the blind hemifield.

Ten Brink AF, Nijboer TC, Bergsma DP, Barton JJ, Van der Stigchel S - PLoS ONE (2015)

Mean saccade latency of each patient in the three different conditions.Error bars depict standard deviations. Asterisks indicate a significant change in endpoints (* at ɑ = .005; ** at ɑ = .001). No data is displayed for the bimodal disparate condition in the blind visual field of Case 5, since target and distractor could never be in the blind quadrant together.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383622&req=5

pone.0122054.g005: Mean saccade latency of each patient in the three different conditions.Error bars depict standard deviations. Asterisks indicate a significant change in endpoints (* at ɑ = .005; ** at ɑ = .001). No data is displayed for the bimodal disparate condition in the blind visual field of Case 5, since target and distractor could never be in the blind quadrant together.
Mentions: There were effects of condition in the intact ipsilateral hemifield of some but not all hemianopic patients (Fig. 5). The latency was shorter in the bimodal disparate than in the unimodal condition for both Case 1 (p = .004) and Case 4 (p < .001), but not in the bimodal coincident condition. In Case 5, the latency was shorter in both bimodal conditions when compared to the unimodal condition (bimodal coincident: p < .001; bimodal disparate: p = .002). In the blind hemifields no differences were observed in any patient (all p > .05).

Bottom Line: The superior colliculus (SC) is part of the spared pathway that is considered to be responsible for this phenomenon.In one patient with a more limited quadrantano-pia, a facilitation effect of the spatially coincident visual stimulus was observed.We conclude that our results show that multisensory integration is infrequent in the blind field of patients with hemianopia.

View Article: PubMed Central - PubMed

Affiliation: Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, The Netherlands; Brain Center Rudolf Magnus Institute of Neuroscience and Centre of Excellence for Rehabilitation Medicine, University Medical Centre Utrecht and Rehabilitation Centre De Hoogstraat, Utrecht, The Netherlands.

ABSTRACT
In patients with visual hemifield defects residual visual functions may be present, a phenomenon called blindsight. The superior colliculus (SC) is part of the spared pathway that is considered to be responsible for this phenomenon. Given that the SC processes input from different modalities and is involved in the programming of saccadic eye movements, the aim of the present study was to examine whether multimodal integration can modulate oculomotor competition in the damaged hemifield. We conducted two experiments with eight patients who had visual field defects due to lesions that affected the retinogeniculate pathway but spared the retinotectal direct SC pathway. They had to make saccades to an auditory target that was presented alone or in combination with a visual stimulus. The visual stimulus could either be spatially coincident with the auditory target (possibly enhancing the auditory target signal), or spatially disparate to the auditory target (possibly competing with the auditory tar-get signal). For each patient we compared the saccade endpoint deviation in these two bi-modal conditions with the endpoint deviation in the unimodal condition (auditory target alone). In all seven hemianopic patients, saccade accuracy was affected only by visual stimuli in the intact, but not in the blind visual field. In one patient with a more limited quadrantano-pia, a facilitation effect of the spatially coincident visual stimulus was observed. We conclude that our results show that multisensory integration is infrequent in the blind field of patients with hemianopia.

No MeSH data available.


Related in: MedlinePlus