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Opisthorchiasis: an overlooked danger.

Ogorodova LM, Fedorova OS, Sripa B, Mordvinov VA, Katokhin AV, Keiser J, Odermatt P, Brindley PJ, Mayboroda OA, Velavan TP, Freidin MB, Sazonov AE, Saltykova IV, Pakharukova MY, Kovshirina YV, Kaloulis K, Krylova OY, Yazdanbakhsh M, TOPIC Consorti - PLoS Negl Trop Dis (2015)

View Article: PubMed Central - PubMed

Affiliation: Siberian State Medical University, Tomsk, Russian Federation.

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A group of helminth infections, caused by liver flukes of the trematode family Opisthorchiidae, were recently the focus of discussions at a meeting where scientists from Russia, Southeast Asia, Europe, and the United States came together in Tomsk city in Western Siberia (Russia) to form a Tomsk OPIsthorchiasis Consortium (TOPIC)... The Opisthorchiidae of importance to humans are Opisthorchis felineus, Opisthorchis viverrini, and Clonorchis sinensis, each of which has a discrete, though occasionally overlapping, geographical distribution: O. felineus is endemic in Europe and Russia; C. sinensis in China, the Republic of Korea, and northern Vietnam; and O. viverrini in Southeast Asia... Therefore, an initiative was taken to organize a meeting in Tomsk, a city located in the region of Western Siberia that is highly endemic for O. felineus, and bring together a multidisciplinary cadre of investigators working on the Opisthorchiidae and infections caused by these fish-borne liver flukes... The body of data available on the epidemiology of Opisthorchiidae comes largely from studies conducted on infections with O. viverrini, and increasingly with C. sinensis, in which robust data have been, and are being, collected in Southeast Asia to map the endemic regions and to quantify the extent of the morbidity associated with the infections... Data presented by Peter Odermatt indicated that it might be necessary to increase the dose of praziquantel to 75 mg/kg, but at the risk of increasing adverse events, which is an important factor for community compliance... The search for new therapies that are more effective and have reduced adverse events has come up with potential new drugs, such as tribendimidine... In comparison with other parasitic helminths, relatively little has been done on the immunological profiling of humans infected with Opisthorchiidae, especially beyond O. viverrini infections... The immunoepidemiological studies in the region of Tomsk comparing subjects infected with and without O. felineus has indicated that there is TH2 skewing as evident from elevated IgE in infected subjects compared to uninfected, but that the levels are much lower than what is found in studies of helminth infected subjects in Ghana where schistosomiasis is highly prevalent or in Indonesia in communities with geohelminth infections... This is of particular importance also because of the possible link to the development of cancer... Prognosis of cancer is poor if regulatory T cells are found in tumours and a number of studies in experimental models have indicated that regulatory T cells are associated with faster tumour growth... These studies form a paradigm for assessing whether tissue pathology/cancer development is controlled by inflammation as a result of gene–environment interaction... Attempts to use molecular approaches to detect O. felineus in hospital-based studies in Europe where infections are found sporadically have been described... Novel data were also presented on studies on praziquantel effects in the O. felineus hamster model and in vitro on juvenile and adult worms, particularly, about parasite motility, viability, and tegument damage after praziquantel treatment... The data presented and discussed led us to the conclusion that there are many groups with overlapping interests and relevant expertise that are willing to work together towards the common aim of controlling liver fluke infections and associated pathologies worldwide... Most importantly, it was stressed that this is a starting point for inviting other groups actively working in the field of liver fluke research to join the Tomsk Opisthorchiasis Consortium by contacting Ludmila Ogorodova from Siberian State Medical University, Tomsk, Russia (topic.consortium@gmail.com).

No MeSH data available.


Consortium high level timelines/activities.1. Siberian State Medical University, Tomsk, Russian Federation, 2. Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, the Netherlands, 3. Department of Parasitology and Leiden Parasite Immunology Group, Leiden University Medical Center, Leiden, the Netherlands, 4. George Washington University Medical Center, United States, 5. Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation, 6. Institute of Tropical Medicine, University of Tübingen, Germany, 7. Khon Kaen University, Khon Kaen, Thailand, 8. Pfizer LLC, Moscow, Russian Federation, 9. ReMedys Foundation, Geneva, Switzerland, 10. Royal Brompton Hospital, United Kingdom; Research Institute for Medical Genetics, Tomsk, Russian Federation, 11. Swiss Tropical and Public Health Institute, Basel, Switzerland.
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pntd.0003563.g001: Consortium high level timelines/activities.1. Siberian State Medical University, Tomsk, Russian Federation, 2. Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, the Netherlands, 3. Department of Parasitology and Leiden Parasite Immunology Group, Leiden University Medical Center, Leiden, the Netherlands, 4. George Washington University Medical Center, United States, 5. Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation, 6. Institute of Tropical Medicine, University of Tübingen, Germany, 7. Khon Kaen University, Khon Kaen, Thailand, 8. Pfizer LLC, Moscow, Russian Federation, 9. ReMedys Foundation, Geneva, Switzerland, 10. Royal Brompton Hospital, United Kingdom; Research Institute for Medical Genetics, Tomsk, Russian Federation, 11. Swiss Tropical and Public Health Institute, Basel, Switzerland.

Mentions: The Consortium shall operate through, and expand towards, several parallel research collaborative activities/work packages, depicted in the high level roadmap (Fig. 1), such as: burden/severity and control at the community; clinical studies; biology, and ecology of parasites; host–parasite interactions; knowledge/technology transfer.


Opisthorchiasis: an overlooked danger.

Ogorodova LM, Fedorova OS, Sripa B, Mordvinov VA, Katokhin AV, Keiser J, Odermatt P, Brindley PJ, Mayboroda OA, Velavan TP, Freidin MB, Sazonov AE, Saltykova IV, Pakharukova MY, Kovshirina YV, Kaloulis K, Krylova OY, Yazdanbakhsh M, TOPIC Consorti - PLoS Negl Trop Dis (2015)

Consortium high level timelines/activities.1. Siberian State Medical University, Tomsk, Russian Federation, 2. Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, the Netherlands, 3. Department of Parasitology and Leiden Parasite Immunology Group, Leiden University Medical Center, Leiden, the Netherlands, 4. George Washington University Medical Center, United States, 5. Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation, 6. Institute of Tropical Medicine, University of Tübingen, Germany, 7. Khon Kaen University, Khon Kaen, Thailand, 8. Pfizer LLC, Moscow, Russian Federation, 9. ReMedys Foundation, Geneva, Switzerland, 10. Royal Brompton Hospital, United Kingdom; Research Institute for Medical Genetics, Tomsk, Russian Federation, 11. Swiss Tropical and Public Health Institute, Basel, Switzerland.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383567&req=5

pntd.0003563.g001: Consortium high level timelines/activities.1. Siberian State Medical University, Tomsk, Russian Federation, 2. Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, the Netherlands, 3. Department of Parasitology and Leiden Parasite Immunology Group, Leiden University Medical Center, Leiden, the Netherlands, 4. George Washington University Medical Center, United States, 5. Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation, 6. Institute of Tropical Medicine, University of Tübingen, Germany, 7. Khon Kaen University, Khon Kaen, Thailand, 8. Pfizer LLC, Moscow, Russian Federation, 9. ReMedys Foundation, Geneva, Switzerland, 10. Royal Brompton Hospital, United Kingdom; Research Institute for Medical Genetics, Tomsk, Russian Federation, 11. Swiss Tropical and Public Health Institute, Basel, Switzerland.
Mentions: The Consortium shall operate through, and expand towards, several parallel research collaborative activities/work packages, depicted in the high level roadmap (Fig. 1), such as: burden/severity and control at the community; clinical studies; biology, and ecology of parasites; host–parasite interactions; knowledge/technology transfer.

View Article: PubMed Central - PubMed

Affiliation: Siberian State Medical University, Tomsk, Russian Federation.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

A group of helminth infections, caused by liver flukes of the trematode family Opisthorchiidae, were recently the focus of discussions at a meeting where scientists from Russia, Southeast Asia, Europe, and the United States came together in Tomsk city in Western Siberia (Russia) to form a Tomsk OPIsthorchiasis Consortium (TOPIC)... The Opisthorchiidae of importance to humans are Opisthorchis felineus, Opisthorchis viverrini, and Clonorchis sinensis, each of which has a discrete, though occasionally overlapping, geographical distribution: O. felineus is endemic in Europe and Russia; C. sinensis in China, the Republic of Korea, and northern Vietnam; and O. viverrini in Southeast Asia... Therefore, an initiative was taken to organize a meeting in Tomsk, a city located in the region of Western Siberia that is highly endemic for O. felineus, and bring together a multidisciplinary cadre of investigators working on the Opisthorchiidae and infections caused by these fish-borne liver flukes... The body of data available on the epidemiology of Opisthorchiidae comes largely from studies conducted on infections with O. viverrini, and increasingly with C. sinensis, in which robust data have been, and are being, collected in Southeast Asia to map the endemic regions and to quantify the extent of the morbidity associated with the infections... Data presented by Peter Odermatt indicated that it might be necessary to increase the dose of praziquantel to 75 mg/kg, but at the risk of increasing adverse events, which is an important factor for community compliance... The search for new therapies that are more effective and have reduced adverse events has come up with potential new drugs, such as tribendimidine... In comparison with other parasitic helminths, relatively little has been done on the immunological profiling of humans infected with Opisthorchiidae, especially beyond O. viverrini infections... The immunoepidemiological studies in the region of Tomsk comparing subjects infected with and without O. felineus has indicated that there is TH2 skewing as evident from elevated IgE in infected subjects compared to uninfected, but that the levels are much lower than what is found in studies of helminth infected subjects in Ghana where schistosomiasis is highly prevalent or in Indonesia in communities with geohelminth infections... This is of particular importance also because of the possible link to the development of cancer... Prognosis of cancer is poor if regulatory T cells are found in tumours and a number of studies in experimental models have indicated that regulatory T cells are associated with faster tumour growth... These studies form a paradigm for assessing whether tissue pathology/cancer development is controlled by inflammation as a result of gene–environment interaction... Attempts to use molecular approaches to detect O. felineus in hospital-based studies in Europe where infections are found sporadically have been described... Novel data were also presented on studies on praziquantel effects in the O. felineus hamster model and in vitro on juvenile and adult worms, particularly, about parasite motility, viability, and tegument damage after praziquantel treatment... The data presented and discussed led us to the conclusion that there are many groups with overlapping interests and relevant expertise that are willing to work together towards the common aim of controlling liver fluke infections and associated pathologies worldwide... Most importantly, it was stressed that this is a starting point for inviting other groups actively working in the field of liver fluke research to join the Tomsk Opisthorchiasis Consortium by contacting Ludmila Ogorodova from Siberian State Medical University, Tomsk, Russia (topic.consortium@gmail.com).

No MeSH data available.