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Infliximab preferentially induces clinical remission and mucosal healing in short course Crohn's disease with luminal lesions through balancing abnormal immune response in gut mucosa.

Yu L, Yang X, Xia L, Zhong J, Ge W, Wu J, Liu H, Liu F, Liu Z - Mediators Inflamm. (2015)

Bottom Line: Patients with short disease duration (22.2 ± 23.2 months) and luminal lesions showed better effects compared to those with long disease duration (71.0 ± 58.2 months) or stricturing and penetrating lesions.No serious adverse events occurred to terminate treatment.Taken together, our studies demonstrated that IFX is efficacious and safe in inducing clinical remission, promoting mucosal healing, and downregulating Th1/Th17-mediated immune response in short course CD patients with luminal lesions.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, The Shanghai Tenth People's Hospital of Tongji University, Shanghai 200072, China.

ABSTRACT
This study was undertaken to evaluate the efficacy of infliximab (IFX) in treatment of Crohn's disease (CD) patients. 106 CD patients were undergoing treatment with IFX from five hospitals in Shanghai, China. Clinical remission to IFX induction therapy was defined as Crohn's disease activity index (CDAI) < 150. Clinical response was assessed by a decrease in CDAI ≥ 70, and the failure as a CDAI was not significantly changed or increased. Ten weeks after therapy, 61 (57.5%) patients achieved clinical remission, 17 (16.0%) had clinical response, and the remaining 28 (26.4%) were failed. In remission group, significant changes were observed in CDAI, the Simple Endoscopic Score for Crohn's Disease (SES-CD), and serum indexes. Patients with short disease duration (22.2 ± 23.2 months) and luminal lesions showed better effects compared to those with long disease duration (71.0 ± 58.2 months) or stricturing and penetrating lesions. IFX markedly downregulated Th1/Th17-mediated immune response but promoted IL-25 production in intestinal mucosa from remission group. No serious adverse events occurred to terminate treatment. Taken together, our studies demonstrated that IFX is efficacious and safe in inducing clinical remission, promoting mucosal healing, and downregulating Th1/Th17-mediated immune response in short course CD patients with luminal lesions.

No MeSH data available.


Related in: MedlinePlus

IFX therapy promotes intestinal mucosal healing in CD patients. Representative endoscopic photographs are demonstrated from a patient in remission group (a, b), a patient from response group (c, d), and a patient from failure group (e, f) before (a, c, and e) and 10 weeks after IFX treatment (b, d, and f).
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fig2: IFX therapy promotes intestinal mucosal healing in CD patients. Representative endoscopic photographs are demonstrated from a patient in remission group (a, b), a patient from response group (c, d), and a patient from failure group (e, f) before (a, c, and e) and 10 weeks after IFX treatment (b, d, and f).

Mentions: To evaluate intestinal mucosal healing after IFX therapy, all patients underwent endoscopy before and 10 weeks after IFX induction therapy. As shown in Figures 1 and 2, SES-CD was found to be significantly decreased 10 weeks after IFX therapy compared with that before therapy in all patients (13.6 ± 7.7 versus 7.75 ± 8.7; P < 0.05). Surprisingly, the mean values of SES-CD from CD patients in remission group were markedly decreased 10 weeks after TNF administration compared to those before IFX treatment (7.7 ± 7.0 versus 2.9 ± 5.3; P < 0.01). Of note, 28 patients (26.4%) got endoscopic remission, 20 patients (18.9%) were in deep remission (both SES-CD ≤ 2 and CDAI < 150), 7 (6.6%) were from clinical response group, and the only 1 left was from failure group.


Infliximab preferentially induces clinical remission and mucosal healing in short course Crohn's disease with luminal lesions through balancing abnormal immune response in gut mucosa.

Yu L, Yang X, Xia L, Zhong J, Ge W, Wu J, Liu H, Liu F, Liu Z - Mediators Inflamm. (2015)

IFX therapy promotes intestinal mucosal healing in CD patients. Representative endoscopic photographs are demonstrated from a patient in remission group (a, b), a patient from response group (c, d), and a patient from failure group (e, f) before (a, c, and e) and 10 weeks after IFX treatment (b, d, and f).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4383520&req=5

fig2: IFX therapy promotes intestinal mucosal healing in CD patients. Representative endoscopic photographs are demonstrated from a patient in remission group (a, b), a patient from response group (c, d), and a patient from failure group (e, f) before (a, c, and e) and 10 weeks after IFX treatment (b, d, and f).
Mentions: To evaluate intestinal mucosal healing after IFX therapy, all patients underwent endoscopy before and 10 weeks after IFX induction therapy. As shown in Figures 1 and 2, SES-CD was found to be significantly decreased 10 weeks after IFX therapy compared with that before therapy in all patients (13.6 ± 7.7 versus 7.75 ± 8.7; P < 0.05). Surprisingly, the mean values of SES-CD from CD patients in remission group were markedly decreased 10 weeks after TNF administration compared to those before IFX treatment (7.7 ± 7.0 versus 2.9 ± 5.3; P < 0.01). Of note, 28 patients (26.4%) got endoscopic remission, 20 patients (18.9%) were in deep remission (both SES-CD ≤ 2 and CDAI < 150), 7 (6.6%) were from clinical response group, and the only 1 left was from failure group.

Bottom Line: Patients with short disease duration (22.2 ± 23.2 months) and luminal lesions showed better effects compared to those with long disease duration (71.0 ± 58.2 months) or stricturing and penetrating lesions.No serious adverse events occurred to terminate treatment.Taken together, our studies demonstrated that IFX is efficacious and safe in inducing clinical remission, promoting mucosal healing, and downregulating Th1/Th17-mediated immune response in short course CD patients with luminal lesions.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, The Shanghai Tenth People's Hospital of Tongji University, Shanghai 200072, China.

ABSTRACT
This study was undertaken to evaluate the efficacy of infliximab (IFX) in treatment of Crohn's disease (CD) patients. 106 CD patients were undergoing treatment with IFX from five hospitals in Shanghai, China. Clinical remission to IFX induction therapy was defined as Crohn's disease activity index (CDAI) < 150. Clinical response was assessed by a decrease in CDAI ≥ 70, and the failure as a CDAI was not significantly changed or increased. Ten weeks after therapy, 61 (57.5%) patients achieved clinical remission, 17 (16.0%) had clinical response, and the remaining 28 (26.4%) were failed. In remission group, significant changes were observed in CDAI, the Simple Endoscopic Score for Crohn's Disease (SES-CD), and serum indexes. Patients with short disease duration (22.2 ± 23.2 months) and luminal lesions showed better effects compared to those with long disease duration (71.0 ± 58.2 months) or stricturing and penetrating lesions. IFX markedly downregulated Th1/Th17-mediated immune response but promoted IL-25 production in intestinal mucosa from remission group. No serious adverse events occurred to terminate treatment. Taken together, our studies demonstrated that IFX is efficacious and safe in inducing clinical remission, promoting mucosal healing, and downregulating Th1/Th17-mediated immune response in short course CD patients with luminal lesions.

No MeSH data available.


Related in: MedlinePlus