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Role of IL-38 and its related cytokines in inflammation.

Yuan X, Peng X, Li Y, Li M - Mediators Inflamm. (2015)

Bottom Line: IL-38 inhibits the production of T-cell cytokines IL-17 and IL-22.IL-38-related cytokines, including IL-1Ra and IL-36Ra, are involved in the regulation of inflammation and immune responses.The study of IL-38 and IL-38-related cytokines might provide new insights for developing anti-inflammatory treatments in the near future.

View Article: PubMed Central - PubMed

Affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, Department of Immunology, Ningbo University School of Medicine, Ningbo 315211, China.

ABSTRACT
Interleukin- (IL-) 38 is a recently discovered cytokine and is the tenth member of the IL-1 cytokine family. IL-38 shares structural features with IL-1 receptor antagonist (IL-1Ra) and IL-36Ra. IL-36R is the specific receptor of IL-38, a partial receptor antagonist of IL-36. IL-38 inhibits the production of T-cell cytokines IL-17 and IL-22. IL-38 also inhibits the production of IL-8 induced by IL-36γ, thus inhibiting inflammatory responses. IL-38-related cytokines, including IL-1Ra and IL-36Ra, are involved in the regulation of inflammation and immune responses. The study of IL-38 and IL-38-related cytokines might provide new insights for developing anti-inflammatory treatments in the near future.

No MeSH data available.


Related in: MedlinePlus

Receptor and signaling pathway of IL-38.
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Related In: Results  -  Collection


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fig2: Receptor and signaling pathway of IL-38.

Mentions: The most recently identified IL-1 family members are widely expressed in inflammatory cells. These cytokines combine with the cell-surface receptor IL-1R and induce downstream signaling, including downstream nuclear transcripts such as nuclear factor-κB (NF-κB) and activator protein-1 (AP-1). Furthermore, as a feedback and adjustment mechanism, these signaling molecules induced the expression of cyclooxygenase, nitric oxide synthase, and other inflammatory mediators to promote the development of inflammation [19, 20]. In line with the characteristics of IL-38 and the homology of IL-38 and IL-36Ra, it can be concluded that IL-38 has a role in inflammatory disease by IL-36Ra pathway-related molecules (Figure 2). The biological function of IL-38 is to inhibit IL-36 cytokine (IL-36α, IL-36β, and IL-36γ) binding to IL-36R, similar to IL-36Ra. According to its activity as a receptor antagonist, IL-38 may have an anti-inflammatory function. IL-38 might also be related to IL-1R and IL-18R signaling pathways, although there is no evidence regarding its role in these specific signaling pathways.


Role of IL-38 and its related cytokines in inflammation.

Yuan X, Peng X, Li Y, Li M - Mediators Inflamm. (2015)

Receptor and signaling pathway of IL-38.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4383490&req=5

fig2: Receptor and signaling pathway of IL-38.
Mentions: The most recently identified IL-1 family members are widely expressed in inflammatory cells. These cytokines combine with the cell-surface receptor IL-1R and induce downstream signaling, including downstream nuclear transcripts such as nuclear factor-κB (NF-κB) and activator protein-1 (AP-1). Furthermore, as a feedback and adjustment mechanism, these signaling molecules induced the expression of cyclooxygenase, nitric oxide synthase, and other inflammatory mediators to promote the development of inflammation [19, 20]. In line with the characteristics of IL-38 and the homology of IL-38 and IL-36Ra, it can be concluded that IL-38 has a role in inflammatory disease by IL-36Ra pathway-related molecules (Figure 2). The biological function of IL-38 is to inhibit IL-36 cytokine (IL-36α, IL-36β, and IL-36γ) binding to IL-36R, similar to IL-36Ra. According to its activity as a receptor antagonist, IL-38 may have an anti-inflammatory function. IL-38 might also be related to IL-1R and IL-18R signaling pathways, although there is no evidence regarding its role in these specific signaling pathways.

Bottom Line: IL-38 inhibits the production of T-cell cytokines IL-17 and IL-22.IL-38-related cytokines, including IL-1Ra and IL-36Ra, are involved in the regulation of inflammation and immune responses.The study of IL-38 and IL-38-related cytokines might provide new insights for developing anti-inflammatory treatments in the near future.

View Article: PubMed Central - PubMed

Affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, Department of Immunology, Ningbo University School of Medicine, Ningbo 315211, China.

ABSTRACT
Interleukin- (IL-) 38 is a recently discovered cytokine and is the tenth member of the IL-1 cytokine family. IL-38 shares structural features with IL-1 receptor antagonist (IL-1Ra) and IL-36Ra. IL-36R is the specific receptor of IL-38, a partial receptor antagonist of IL-36. IL-38 inhibits the production of T-cell cytokines IL-17 and IL-22. IL-38 also inhibits the production of IL-8 induced by IL-36γ, thus inhibiting inflammatory responses. IL-38-related cytokines, including IL-1Ra and IL-36Ra, are involved in the regulation of inflammation and immune responses. The study of IL-38 and IL-38-related cytokines might provide new insights for developing anti-inflammatory treatments in the near future.

No MeSH data available.


Related in: MedlinePlus