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Rate of corneal collagen crosslinking redo in private practice: risk factors and safety.

Antoun J, Slim E, El Hachem R, Chelala E, Jabbour E, Cherfan G, Jarade EF - J Ophthalmol (2015)

Bottom Line: Results.Conclusion.A close followup is thus mandatory, even years after the procedure.

View Article: PubMed Central - PubMed

Affiliation: Saint Joseph University Hospital, Faculty of Medicine, P.O. Box 166830, Beirut, Lebanon ; Beirut Eye Specialist Hospital, Al-Mathaf Square, P.O. Box 116-5311, Beirut, Lebanon.

ABSTRACT
Objective. To report the rate of progression of keratectasia after primary crosslinking (CXL) and evaluate the safety and efficiency of CXL redo. Materials and Methods. We conducted a retrospective analysis of the patients who underwent CXL between 2010 and 2013 at the Beirut Eye Specialist Hospital, Lebanon. Progression of keratectasia was based on the presence of an increase in maximum keratometry of 1.00 D, a change in the map difference between two consecutive topographies of 1.00 D, a deterioration of visual acuity, or any change in the refraction. Primary and redo CXL were done using the same protocol. Results. Among the 221 eyes of 130 patients who underwent CXL, 7 eyes (3.17%) of five patients met the criteria of progression. All patients reported a history of allergic conjunctivitis and eye rubbing and progressed within 9 to 48 months. No complications were noted and all patients were stable 1 year after CXL redo. Conclusion. Allergic conjunctivitis and eye rubbing were the only risk factors associated with keratoconus progression after CXL. A close followup is thus mandatory, even years after the procedure. CXL redo seems to be a safe and efficient technique to halt the progression after a primary CXL.

No MeSH data available.


Related in: MedlinePlus

A map difference showing progression after primary corneal collagen crosslinking. B represents corneal topography 6 months after primary CXL, and A shows corneal topography 12 months after primary CXL. The map difference (difference A-B) shows the progression after initial CXL with +2.5 and +3.4 D of difference between successive topographies (white circle).
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fig1: A map difference showing progression after primary corneal collagen crosslinking. B represents corneal topography 6 months after primary CXL, and A shows corneal topography 12 months after primary CXL. The map difference (difference A-B) shows the progression after initial CXL with +2.5 and +3.4 D of difference between successive topographies (white circle).

Mentions: Progression of KC was noticed more than one year (14 to 48 months) after the original CXL in 6 eyes of four patients (2 males and 2 females, one patient was 19 years old, and 3 were 26–28 years old) and one eye (30-year-old male) was diagnosed with KC progression 9 months after the original CXL. The mean time of KC progression after original CXL was 29.14 months. Progression was noted by all the patients after a decrease in CDVA and was evidenced by progression in corneal topography (Figure 1). Progression was simultaneously noted in both eyes in all patients who had bilateral disease evolution.


Rate of corneal collagen crosslinking redo in private practice: risk factors and safety.

Antoun J, Slim E, El Hachem R, Chelala E, Jabbour E, Cherfan G, Jarade EF - J Ophthalmol (2015)

A map difference showing progression after primary corneal collagen crosslinking. B represents corneal topography 6 months after primary CXL, and A shows corneal topography 12 months after primary CXL. The map difference (difference A-B) shows the progression after initial CXL with +2.5 and +3.4 D of difference between successive topographies (white circle).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4383466&req=5

fig1: A map difference showing progression after primary corneal collagen crosslinking. B represents corneal topography 6 months after primary CXL, and A shows corneal topography 12 months after primary CXL. The map difference (difference A-B) shows the progression after initial CXL with +2.5 and +3.4 D of difference between successive topographies (white circle).
Mentions: Progression of KC was noticed more than one year (14 to 48 months) after the original CXL in 6 eyes of four patients (2 males and 2 females, one patient was 19 years old, and 3 were 26–28 years old) and one eye (30-year-old male) was diagnosed with KC progression 9 months after the original CXL. The mean time of KC progression after original CXL was 29.14 months. Progression was noted by all the patients after a decrease in CDVA and was evidenced by progression in corneal topography (Figure 1). Progression was simultaneously noted in both eyes in all patients who had bilateral disease evolution.

Bottom Line: Results.Conclusion.A close followup is thus mandatory, even years after the procedure.

View Article: PubMed Central - PubMed

Affiliation: Saint Joseph University Hospital, Faculty of Medicine, P.O. Box 166830, Beirut, Lebanon ; Beirut Eye Specialist Hospital, Al-Mathaf Square, P.O. Box 116-5311, Beirut, Lebanon.

ABSTRACT
Objective. To report the rate of progression of keratectasia after primary crosslinking (CXL) and evaluate the safety and efficiency of CXL redo. Materials and Methods. We conducted a retrospective analysis of the patients who underwent CXL between 2010 and 2013 at the Beirut Eye Specialist Hospital, Lebanon. Progression of keratectasia was based on the presence of an increase in maximum keratometry of 1.00 D, a change in the map difference between two consecutive topographies of 1.00 D, a deterioration of visual acuity, or any change in the refraction. Primary and redo CXL were done using the same protocol. Results. Among the 221 eyes of 130 patients who underwent CXL, 7 eyes (3.17%) of five patients met the criteria of progression. All patients reported a history of allergic conjunctivitis and eye rubbing and progressed within 9 to 48 months. No complications were noted and all patients were stable 1 year after CXL redo. Conclusion. Allergic conjunctivitis and eye rubbing were the only risk factors associated with keratoconus progression after CXL. A close followup is thus mandatory, even years after the procedure. CXL redo seems to be a safe and efficient technique to halt the progression after a primary CXL.

No MeSH data available.


Related in: MedlinePlus