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Skeleton and glucose metabolism: a bone-pancreas loop.

Faienza MF, Luce V, Ventura A, Colaianni G, Colucci S, Cavallo L, Grano M, Brunetti G - Int J Endocrinol (2015)

Bottom Line: Bone has been considered a structure essential for mobility, calcium homeostasis, and hematopoietic function.Recent advances in bone biology have highlighted the importance of skeleton as an endocrine organ which regulates some metabolic pathways, in particular, insulin signaling and glucose tolerance.This review will point out the role of bone as an endocrine "gland" and, specifically, of bone-specific proteins, as the osteocalcin (Ocn), and proteins involved in bone remodeling, as osteoprotegerin, in the regulation of insulin function and glucose metabolism.

View Article: PubMed Central - PubMed

Affiliation: Section of Pediatrics, Department of Biomedical Sciences and Human Oncology, University of Bari "A. Moro", 70124 Bari, Italy.

ABSTRACT
Bone has been considered a structure essential for mobility, calcium homeostasis, and hematopoietic function. Recent advances in bone biology have highlighted the importance of skeleton as an endocrine organ which regulates some metabolic pathways, in particular, insulin signaling and glucose tolerance. This review will point out the role of bone as an endocrine "gland" and, specifically, of bone-specific proteins, as the osteocalcin (Ocn), and proteins involved in bone remodeling, as osteoprotegerin, in the regulation of insulin function and glucose metabolism.

No MeSH data available.


Interplay between Ocn and insulin secretion/sensitivity.
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Related In: Results  -  Collection


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fig1: Interplay between Ocn and insulin secretion/sensitivity.

Mentions: The decarboxylation of Ocn is dependent on bone resorption: insulin signaling in OBs favors the differentiation of OCs and the formation of resorption lacunae by inhibiting the expression of OPG [14]. The low pH present within these lacunae promotes the decarboxylation of Ocn and consequently its activation [14] (Figure 1). Conversely, a tyrosine phosphatase produced by Esp (Ptprv) gene blocks Ocn decarboxylation and decreases serum levels of active form of Ocn [21]. The human ortholog of Esp (OST-PTP, also called osteotesticular protein tyrosine phosphatase) is not active in humans but recent studies have shown that there are additional tyrosine phosphatases, such as TC-PTP1, expressed in OBs [21–24]. These phosphatases can regulate Ocn activity and glucose homeostasis by acting on the insulin signaling pathway in the OBs [21, 23, 24].


Skeleton and glucose metabolism: a bone-pancreas loop.

Faienza MF, Luce V, Ventura A, Colaianni G, Colucci S, Cavallo L, Grano M, Brunetti G - Int J Endocrinol (2015)

Interplay between Ocn and insulin secretion/sensitivity.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4383460&req=5

fig1: Interplay between Ocn and insulin secretion/sensitivity.
Mentions: The decarboxylation of Ocn is dependent on bone resorption: insulin signaling in OBs favors the differentiation of OCs and the formation of resorption lacunae by inhibiting the expression of OPG [14]. The low pH present within these lacunae promotes the decarboxylation of Ocn and consequently its activation [14] (Figure 1). Conversely, a tyrosine phosphatase produced by Esp (Ptprv) gene blocks Ocn decarboxylation and decreases serum levels of active form of Ocn [21]. The human ortholog of Esp (OST-PTP, also called osteotesticular protein tyrosine phosphatase) is not active in humans but recent studies have shown that there are additional tyrosine phosphatases, such as TC-PTP1, expressed in OBs [21–24]. These phosphatases can regulate Ocn activity and glucose homeostasis by acting on the insulin signaling pathway in the OBs [21, 23, 24].

Bottom Line: Bone has been considered a structure essential for mobility, calcium homeostasis, and hematopoietic function.Recent advances in bone biology have highlighted the importance of skeleton as an endocrine organ which regulates some metabolic pathways, in particular, insulin signaling and glucose tolerance.This review will point out the role of bone as an endocrine "gland" and, specifically, of bone-specific proteins, as the osteocalcin (Ocn), and proteins involved in bone remodeling, as osteoprotegerin, in the regulation of insulin function and glucose metabolism.

View Article: PubMed Central - PubMed

Affiliation: Section of Pediatrics, Department of Biomedical Sciences and Human Oncology, University of Bari "A. Moro", 70124 Bari, Italy.

ABSTRACT
Bone has been considered a structure essential for mobility, calcium homeostasis, and hematopoietic function. Recent advances in bone biology have highlighted the importance of skeleton as an endocrine organ which regulates some metabolic pathways, in particular, insulin signaling and glucose tolerance. This review will point out the role of bone as an endocrine "gland" and, specifically, of bone-specific proteins, as the osteocalcin (Ocn), and proteins involved in bone remodeling, as osteoprotegerin, in the regulation of insulin function and glucose metabolism.

No MeSH data available.