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Models for predicting the adult height and age at first menstruation of girls with idiopathic central precocious puberty.

Giabicani E, Lemaire P, Brauner R - PLoS ONE (2015)

Bottom Line: The actual AH was lower than the calculated AH by more than 1 SD (5.6 cm) in 11 girls (8.0%).The similarity of the formulae for both groups suggests that the treatment had no significant effect on the AH.However, the criteria used to select treatment suggest that it prevents the deterioration of AH in cases with rapidly evolving form of CPP.

View Article: PubMed Central - PubMed

Affiliation: Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.

ABSTRACT

Background: It is difficult to determine whether to treat a given girl who has idiopathic central precocious puberty (CPP) with gonadotropin-releasing hormone analog (GnRHa) in terms of adult height (AH). The objective was to provide an easy tool for predicting AH and age at first menstruation at initial evaluation to help guide the decision regarding whether to treat.

Methods: Data analysis using multiple linear regression models was performed in 134 girls with CPP. Among them 78 were given GnRHa because of low predicted AH (n=45), pubertal luteinising hormone (LH)/follicle-stimulating hormone peaks (FSH) ratio (n=50) and/or high plasma estradiol concentration (n=45). 56 girls were followed without treatment.

Results: In the whole population, the actual AH (162.1±5.61 cm) was similar to target height (161.7±4.91 cm) and to AH predicted by the Bayley and Pinneau method (161.9±7.98 cm). Separated models for treated and untreated girls provide very close estimations, leading to a unique formula for both groups. The AH (cm) could be calculated at the initial evaluation: 2.21 (height at initial evaluation, SD) + 2.32 (target height, SD) - 1.83 (LH/FSH peaks ratio) + 159.68. The actual AH was lower than the calculated AH by more than 1 SD (5.6 cm) in 11 girls (8.0%). The time between onset of puberty and first menstruation (in untreated girls) can be estimated with: 10.9 - 0.57 (LH/FSH peaks ratio). The formulae are available at http://www.kamick.org/lemaire/med/girls-cpp15.html.

Conclusions: We established formulae that can be used at an initial evaluation to predict the AH, and the time between onset of puberty and first menstruation after spontaneous puberty. The similarity of the formulae for both groups suggests that the treatment had no significant effect on the AH. However, the criteria used to select treatment suggest that it prevents the deterioration of AH in cases with rapidly evolving form of CPP.

No MeSH data available.


Related in: MedlinePlus

Correlation between actual adult height and calculated adult height (left) or adult height predicted by the Bayley Pinneau method [25] (right) in 78 treated (empty circles) and 56 untreated girls (plain circles) with idiopathic CPP using the formula from http://www.kamick.org/lemaire/med/girls-cpp15.html.Plain line represents the reference perfect prediction (calculated = actual), and dotted lines represent ± 1 SD from that value.
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pone.0120588.g003: Correlation between actual adult height and calculated adult height (left) or adult height predicted by the Bayley Pinneau method [25] (right) in 78 treated (empty circles) and 56 untreated girls (plain circles) with idiopathic CPP using the formula from http://www.kamick.org/lemaire/med/girls-cpp15.html.Plain line represents the reference perfect prediction (calculated = actual), and dotted lines represent ± 1 SD from that value.

Mentions: Models were first established separately for the treated and untreated girls, but they happened to be very similar and output similar predictions for the whole group. Thus, we established a model for the whole population using the following formula (Fig. 3):


Models for predicting the adult height and age at first menstruation of girls with idiopathic central precocious puberty.

Giabicani E, Lemaire P, Brauner R - PLoS ONE (2015)

Correlation between actual adult height and calculated adult height (left) or adult height predicted by the Bayley Pinneau method [25] (right) in 78 treated (empty circles) and 56 untreated girls (plain circles) with idiopathic CPP using the formula from http://www.kamick.org/lemaire/med/girls-cpp15.html.Plain line represents the reference perfect prediction (calculated = actual), and dotted lines represent ± 1 SD from that value.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383451&req=5

pone.0120588.g003: Correlation between actual adult height and calculated adult height (left) or adult height predicted by the Bayley Pinneau method [25] (right) in 78 treated (empty circles) and 56 untreated girls (plain circles) with idiopathic CPP using the formula from http://www.kamick.org/lemaire/med/girls-cpp15.html.Plain line represents the reference perfect prediction (calculated = actual), and dotted lines represent ± 1 SD from that value.
Mentions: Models were first established separately for the treated and untreated girls, but they happened to be very similar and output similar predictions for the whole group. Thus, we established a model for the whole population using the following formula (Fig. 3):

Bottom Line: The actual AH was lower than the calculated AH by more than 1 SD (5.6 cm) in 11 girls (8.0%).The similarity of the formulae for both groups suggests that the treatment had no significant effect on the AH.However, the criteria used to select treatment suggest that it prevents the deterioration of AH in cases with rapidly evolving form of CPP.

View Article: PubMed Central - PubMed

Affiliation: Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.

ABSTRACT

Background: It is difficult to determine whether to treat a given girl who has idiopathic central precocious puberty (CPP) with gonadotropin-releasing hormone analog (GnRHa) in terms of adult height (AH). The objective was to provide an easy tool for predicting AH and age at first menstruation at initial evaluation to help guide the decision regarding whether to treat.

Methods: Data analysis using multiple linear regression models was performed in 134 girls with CPP. Among them 78 were given GnRHa because of low predicted AH (n=45), pubertal luteinising hormone (LH)/follicle-stimulating hormone peaks (FSH) ratio (n=50) and/or high plasma estradiol concentration (n=45). 56 girls were followed without treatment.

Results: In the whole population, the actual AH (162.1±5.61 cm) was similar to target height (161.7±4.91 cm) and to AH predicted by the Bayley and Pinneau method (161.9±7.98 cm). Separated models for treated and untreated girls provide very close estimations, leading to a unique formula for both groups. The AH (cm) could be calculated at the initial evaluation: 2.21 (height at initial evaluation, SD) + 2.32 (target height, SD) - 1.83 (LH/FSH peaks ratio) + 159.68. The actual AH was lower than the calculated AH by more than 1 SD (5.6 cm) in 11 girls (8.0%). The time between onset of puberty and first menstruation (in untreated girls) can be estimated with: 10.9 - 0.57 (LH/FSH peaks ratio). The formulae are available at http://www.kamick.org/lemaire/med/girls-cpp15.html.

Conclusions: We established formulae that can be used at an initial evaluation to predict the AH, and the time between onset of puberty and first menstruation after spontaneous puberty. The similarity of the formulae for both groups suggests that the treatment had no significant effect on the AH. However, the criteria used to select treatment suggest that it prevents the deterioration of AH in cases with rapidly evolving form of CPP.

No MeSH data available.


Related in: MedlinePlus