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Models for predicting the adult height and age at first menstruation of girls with idiopathic central precocious puberty.

Giabicani E, Lemaire P, Brauner R - PLoS ONE (2015)

Bottom Line: The actual AH was lower than the calculated AH by more than 1 SD (5.6 cm) in 11 girls (8.0%).The similarity of the formulae for both groups suggests that the treatment had no significant effect on the AH.However, the criteria used to select treatment suggest that it prevents the deterioration of AH in cases with rapidly evolving form of CPP.

View Article: PubMed Central - PubMed

Affiliation: Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.

ABSTRACT

Background: It is difficult to determine whether to treat a given girl who has idiopathic central precocious puberty (CPP) with gonadotropin-releasing hormone analog (GnRHa) in terms of adult height (AH). The objective was to provide an easy tool for predicting AH and age at first menstruation at initial evaluation to help guide the decision regarding whether to treat.

Methods: Data analysis using multiple linear regression models was performed in 134 girls with CPP. Among them 78 were given GnRHa because of low predicted AH (n=45), pubertal luteinising hormone (LH)/follicle-stimulating hormone peaks (FSH) ratio (n=50) and/or high plasma estradiol concentration (n=45). 56 girls were followed without treatment.

Results: In the whole population, the actual AH (162.1±5.61 cm) was similar to target height (161.7±4.91 cm) and to AH predicted by the Bayley and Pinneau method (161.9±7.98 cm). Separated models for treated and untreated girls provide very close estimations, leading to a unique formula for both groups. The AH (cm) could be calculated at the initial evaluation: 2.21 (height at initial evaluation, SD) + 2.32 (target height, SD) - 1.83 (LH/FSH peaks ratio) + 159.68. The actual AH was lower than the calculated AH by more than 1 SD (5.6 cm) in 11 girls (8.0%). The time between onset of puberty and first menstruation (in untreated girls) can be estimated with: 10.9 - 0.57 (LH/FSH peaks ratio). The formulae are available at http://www.kamick.org/lemaire/med/girls-cpp15.html.

Conclusions: We established formulae that can be used at an initial evaluation to predict the AH, and the time between onset of puberty and first menstruation after spontaneous puberty. The similarity of the formulae for both groups suggests that the treatment had no significant effect on the AH. However, the criteria used to select treatment suggest that it prevents the deterioration of AH in cases with rapidly evolving form of CPP.

No MeSH data available.


Related in: MedlinePlus

Flow chart of the inclusions of girls with CPP.
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pone.0120588.g001: Flow chart of the inclusions of girls with CPP.

Mentions: The 134 girls were selected from 493 girls with idiopathic CPP [15] (Fig. 1). The age at first menstruation was known for 129 of them. At the initial evaluation, the characteristics of the 134 girls included in the study were similar to those of the 359 girls without AH available, except for the BA advance, BMI, TH and plasma estradiol concentrations (Table 1).


Models for predicting the adult height and age at first menstruation of girls with idiopathic central precocious puberty.

Giabicani E, Lemaire P, Brauner R - PLoS ONE (2015)

Flow chart of the inclusions of girls with CPP.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383451&req=5

pone.0120588.g001: Flow chart of the inclusions of girls with CPP.
Mentions: The 134 girls were selected from 493 girls with idiopathic CPP [15] (Fig. 1). The age at first menstruation was known for 129 of them. At the initial evaluation, the characteristics of the 134 girls included in the study were similar to those of the 359 girls without AH available, except for the BA advance, BMI, TH and plasma estradiol concentrations (Table 1).

Bottom Line: The actual AH was lower than the calculated AH by more than 1 SD (5.6 cm) in 11 girls (8.0%).The similarity of the formulae for both groups suggests that the treatment had no significant effect on the AH.However, the criteria used to select treatment suggest that it prevents the deterioration of AH in cases with rapidly evolving form of CPP.

View Article: PubMed Central - PubMed

Affiliation: Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.

ABSTRACT

Background: It is difficult to determine whether to treat a given girl who has idiopathic central precocious puberty (CPP) with gonadotropin-releasing hormone analog (GnRHa) in terms of adult height (AH). The objective was to provide an easy tool for predicting AH and age at first menstruation at initial evaluation to help guide the decision regarding whether to treat.

Methods: Data analysis using multiple linear regression models was performed in 134 girls with CPP. Among them 78 were given GnRHa because of low predicted AH (n=45), pubertal luteinising hormone (LH)/follicle-stimulating hormone peaks (FSH) ratio (n=50) and/or high plasma estradiol concentration (n=45). 56 girls were followed without treatment.

Results: In the whole population, the actual AH (162.1±5.61 cm) was similar to target height (161.7±4.91 cm) and to AH predicted by the Bayley and Pinneau method (161.9±7.98 cm). Separated models for treated and untreated girls provide very close estimations, leading to a unique formula for both groups. The AH (cm) could be calculated at the initial evaluation: 2.21 (height at initial evaluation, SD) + 2.32 (target height, SD) - 1.83 (LH/FSH peaks ratio) + 159.68. The actual AH was lower than the calculated AH by more than 1 SD (5.6 cm) in 11 girls (8.0%). The time between onset of puberty and first menstruation (in untreated girls) can be estimated with: 10.9 - 0.57 (LH/FSH peaks ratio). The formulae are available at http://www.kamick.org/lemaire/med/girls-cpp15.html.

Conclusions: We established formulae that can be used at an initial evaluation to predict the AH, and the time between onset of puberty and first menstruation after spontaneous puberty. The similarity of the formulae for both groups suggests that the treatment had no significant effect on the AH. However, the criteria used to select treatment suggest that it prevents the deterioration of AH in cases with rapidly evolving form of CPP.

No MeSH data available.


Related in: MedlinePlus