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The diagnostic accuracy of HE4 in lung cancer: a meta-analysis.

Cheng D, Sun Y, He H - Dis. Markers (2015)

Bottom Line: We conducted a comprehensive literature search in PubMed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and WANFANG databases between Jan. 1966 and Nov. 2014.A total of seven articles including 715 cases and 549 controls were included for analysis.In addition, considering the high heterogeneity and potential publication bias, further studies with rigorous design and large sample size are needed in the future.

View Article: PubMed Central - PubMed

Affiliation: Department of Transfusion, First Hospital of China Medical University, Shenyang 110001, China.

ABSTRACT
The diagnostic value of serum HE4 in patients with lung cancer remains controversial. Thus, we performed a systematic review and meta-analysis to assess the diagnostic accuracy of serum HE4 for lung cancer. We conducted a comprehensive literature search in PubMed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and WANFANG databases between Jan. 1966 and Nov. 2014. The diagnostic sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and summary receiver operating characteristic curve (SROC) were pooled by Meta-DiSc 1.4 software. A total of seven articles including 715 cases and 549 controls were included for analysis. The summary estimates for serum HE4 in the diagnosis of lung cancer in these studies were pooled SEN 0.72 (95% CI: 0.68-0.75), SPE 0.85 (95% CI: 0.81-0.88), PLR 4.68 (95% CI: 3.23-6.78), NLR 0.31 (95% CI: 0.24-0.39), and DOR 17.14 (95% CI: 9.72-30.20), and the area under the curve (AUC) was 0.8557. This meta-analysis indicated that serum HE4 is a potential tool in the diagnosis of lung cancer. In addition, considering the high heterogeneity and potential publication bias, further studies with rigorous design and large sample size are needed in the future.

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Related in: MedlinePlus

Funnel plot for the evaluation of potential publication bias in diagnosis of HE4 for lung cancer.
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Related In: Results  -  Collection


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fig4: Funnel plot for the evaluation of potential publication bias in diagnosis of HE4 for lung cancer.

Mentions: To investigate the publication bias, we performed the funnel plot and Egger's test. The shape of funnel plot did not reveal any evidence of obvious asymmetry (Figure 4). The result of Egger's test was 0.090, suggesting no publication bias among the included studies for HE4 in the diagnosis of lung cancer.


The diagnostic accuracy of HE4 in lung cancer: a meta-analysis.

Cheng D, Sun Y, He H - Dis. Markers (2015)

Funnel plot for the evaluation of potential publication bias in diagnosis of HE4 for lung cancer.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4383439&req=5

fig4: Funnel plot for the evaluation of potential publication bias in diagnosis of HE4 for lung cancer.
Mentions: To investigate the publication bias, we performed the funnel plot and Egger's test. The shape of funnel plot did not reveal any evidence of obvious asymmetry (Figure 4). The result of Egger's test was 0.090, suggesting no publication bias among the included studies for HE4 in the diagnosis of lung cancer.

Bottom Line: We conducted a comprehensive literature search in PubMed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and WANFANG databases between Jan. 1966 and Nov. 2014.A total of seven articles including 715 cases and 549 controls were included for analysis.In addition, considering the high heterogeneity and potential publication bias, further studies with rigorous design and large sample size are needed in the future.

View Article: PubMed Central - PubMed

Affiliation: Department of Transfusion, First Hospital of China Medical University, Shenyang 110001, China.

ABSTRACT
The diagnostic value of serum HE4 in patients with lung cancer remains controversial. Thus, we performed a systematic review and meta-analysis to assess the diagnostic accuracy of serum HE4 for lung cancer. We conducted a comprehensive literature search in PubMed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and WANFANG databases between Jan. 1966 and Nov. 2014. The diagnostic sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and summary receiver operating characteristic curve (SROC) were pooled by Meta-DiSc 1.4 software. A total of seven articles including 715 cases and 549 controls were included for analysis. The summary estimates for serum HE4 in the diagnosis of lung cancer in these studies were pooled SEN 0.72 (95% CI: 0.68-0.75), SPE 0.85 (95% CI: 0.81-0.88), PLR 4.68 (95% CI: 3.23-6.78), NLR 0.31 (95% CI: 0.24-0.39), and DOR 17.14 (95% CI: 9.72-30.20), and the area under the curve (AUC) was 0.8557. This meta-analysis indicated that serum HE4 is a potential tool in the diagnosis of lung cancer. In addition, considering the high heterogeneity and potential publication bias, further studies with rigorous design and large sample size are needed in the future.

Show MeSH
Related in: MedlinePlus