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The diagnostic accuracy of HE4 in lung cancer: a meta-analysis.

Cheng D, Sun Y, He H - Dis. Markers (2015)

Bottom Line: We conducted a comprehensive literature search in PubMed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and WANFANG databases between Jan. 1966 and Nov. 2014.A total of seven articles including 715 cases and 549 controls were included for analysis.In addition, considering the high heterogeneity and potential publication bias, further studies with rigorous design and large sample size are needed in the future.

View Article: PubMed Central - PubMed

Affiliation: Department of Transfusion, First Hospital of China Medical University, Shenyang 110001, China.

ABSTRACT
The diagnostic value of serum HE4 in patients with lung cancer remains controversial. Thus, we performed a systematic review and meta-analysis to assess the diagnostic accuracy of serum HE4 for lung cancer. We conducted a comprehensive literature search in PubMed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and WANFANG databases between Jan. 1966 and Nov. 2014. The diagnostic sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and summary receiver operating characteristic curve (SROC) were pooled by Meta-DiSc 1.4 software. A total of seven articles including 715 cases and 549 controls were included for analysis. The summary estimates for serum HE4 in the diagnosis of lung cancer in these studies were pooled SEN 0.72 (95% CI: 0.68-0.75), SPE 0.85 (95% CI: 0.81-0.88), PLR 4.68 (95% CI: 3.23-6.78), NLR 0.31 (95% CI: 0.24-0.39), and DOR 17.14 (95% CI: 9.72-30.20), and the area under the curve (AUC) was 0.8557. This meta-analysis indicated that serum HE4 is a potential tool in the diagnosis of lung cancer. In addition, considering the high heterogeneity and potential publication bias, further studies with rigorous design and large sample size are needed in the future.

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Related in: MedlinePlus

Flow chart describing systematic literature search and study selection process.
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fig1: Flow chart describing systematic literature search and study selection process.

Mentions: The detailed flow diagram of literature retrieval was presented in Figure 1. A total of 41 potentially relevant articles were retrieved after initial databases search. Of 41 searched articles, we excluded 31 articles that were not relevant to our study on the basis of title and abstract. After reviewing the full-text, only seven articles with 715 cases and 549 controls were included for systematic review and meta-analysis [14–20]. The characteristics of the included studies were shown in Table 1. The sample size ranged from 78 to 290. Six studies were performed in Asian [14–16, 18–20] and one in European [17].


The diagnostic accuracy of HE4 in lung cancer: a meta-analysis.

Cheng D, Sun Y, He H - Dis. Markers (2015)

Flow chart describing systematic literature search and study selection process.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4383439&req=5

fig1: Flow chart describing systematic literature search and study selection process.
Mentions: The detailed flow diagram of literature retrieval was presented in Figure 1. A total of 41 potentially relevant articles were retrieved after initial databases search. Of 41 searched articles, we excluded 31 articles that were not relevant to our study on the basis of title and abstract. After reviewing the full-text, only seven articles with 715 cases and 549 controls were included for systematic review and meta-analysis [14–20]. The characteristics of the included studies were shown in Table 1. The sample size ranged from 78 to 290. Six studies were performed in Asian [14–16, 18–20] and one in European [17].

Bottom Line: We conducted a comprehensive literature search in PubMed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and WANFANG databases between Jan. 1966 and Nov. 2014.A total of seven articles including 715 cases and 549 controls were included for analysis.In addition, considering the high heterogeneity and potential publication bias, further studies with rigorous design and large sample size are needed in the future.

View Article: PubMed Central - PubMed

Affiliation: Department of Transfusion, First Hospital of China Medical University, Shenyang 110001, China.

ABSTRACT
The diagnostic value of serum HE4 in patients with lung cancer remains controversial. Thus, we performed a systematic review and meta-analysis to assess the diagnostic accuracy of serum HE4 for lung cancer. We conducted a comprehensive literature search in PubMed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and WANFANG databases between Jan. 1966 and Nov. 2014. The diagnostic sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and summary receiver operating characteristic curve (SROC) were pooled by Meta-DiSc 1.4 software. A total of seven articles including 715 cases and 549 controls were included for analysis. The summary estimates for serum HE4 in the diagnosis of lung cancer in these studies were pooled SEN 0.72 (95% CI: 0.68-0.75), SPE 0.85 (95% CI: 0.81-0.88), PLR 4.68 (95% CI: 3.23-6.78), NLR 0.31 (95% CI: 0.24-0.39), and DOR 17.14 (95% CI: 9.72-30.20), and the area under the curve (AUC) was 0.8557. This meta-analysis indicated that serum HE4 is a potential tool in the diagnosis of lung cancer. In addition, considering the high heterogeneity and potential publication bias, further studies with rigorous design and large sample size are needed in the future.

Show MeSH
Related in: MedlinePlus