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Autistic-like traits in adult patients with mood disorders and schizophrenia.

Matsuo J, Kamio Y, Takahashi H, Ota M, Teraishi T, Hori H, Nagashima A, Takei R, Higuchi T, Motohashi N, Kunugi H - PLoS ONE (2015)

Bottom Line: On the other hand, remitted subjects with MDD did not differ from healthy controls with regard to the prevalence or degree of high autistic-like traits/symptoms.Conversely, autistic-like traits among subjects with MDD were associated with the depressive symptom severity.These findings suggest the importance of evaluating autistic-like traits/symptoms underlying adult-onset psychiatric disorders for the best-suited treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan; Department of Neuropsychiatry, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan.

ABSTRACT
Autism spectrum disorder often co-occurs with other psychiatric disorders. Although a high prevalence of autistic-like traits/symptoms has been identified in the pediatric psychiatric population of normal intelligence, there are no reports from adult psychiatric population. This study examined whether there is a greater prevalence of autistic-like traits/symptoms in patients with adult-onset psychiatric disorders such as major depressive disorder (MDD), bipolar disorder, or schizophrenia, and whether such an association is independent of symptom severity. The subjects were 290 adults of normal intelligence between 25 and 59 years of age (MDD, n=125; bipolar disorder, n=56; schizophrenia, n=44; healthy controls, n=65). Autistic-like traits/symptoms were measured using the Social Responsiveness Scale for Adults. Symptom severity was measured using the Positive and Negative Symptoms Scale, the Hamilton Depression Rating Scale, and/or the Young Mania Rating Scale. Almost half of the clinical subjects, except those with remitted MDD, exhibited autistic-like traits/symptoms at levels typical for sub-threshold or threshold autism spectrum disorder. Furthermore, the proportion of psychiatric patients that demonstrated high autistic-like traits/symptoms was significantly greater than that of healthy controls, and not different between that of remitted or unremitted subjects with bipolar disorder or schizophrenia. On the other hand, remitted subjects with MDD did not differ from healthy controls with regard to the prevalence or degree of high autistic-like traits/symptoms. A substantial proportion of adults with bipolar disorder and schizophrenia showed high autistic-like traits/symptoms independent of symptom severity, suggesting a shared pathophysiology among autism spectrum disorder and these psychiatric disorders. Conversely, autistic-like traits among subjects with MDD were associated with the depressive symptom severity. These findings suggest the importance of evaluating autistic-like traits/symptoms underlying adult-onset psychiatric disorders for the best-suited treatment. Further studies with a prospective design and larger samples are needed.

No MeSH data available.


Related in: MedlinePlus

Comparison of the degree of ALTs among the 7 subgroups.SRS-A total scores were compared among the 7 subgroups (i.e., HC and remitted/unremitted MDD, BPD and SZ) using Kruskal Wallis test; Dunn's test was used for further pair-wise multiple comparison. Results of pair-wise comparison between each clinical subgroup and HC are shown with error bar showing quartile deviation. HC: healthy control. MDD: major depressive disorder. BPD: bipolar disorder. SZ: schizophrenia. R: remitted. U: unremitted. n.s. p>0.05, * p<0.05, ** p<0.01, *** p<0.001 (all against HC)
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pone.0122711.g002: Comparison of the degree of ALTs among the 7 subgroups.SRS-A total scores were compared among the 7 subgroups (i.e., HC and remitted/unremitted MDD, BPD and SZ) using Kruskal Wallis test; Dunn's test was used for further pair-wise multiple comparison. Results of pair-wise comparison between each clinical subgroup and HC are shown with error bar showing quartile deviation. HC: healthy control. MDD: major depressive disorder. BPD: bipolar disorder. SZ: schizophrenia. R: remitted. U: unremitted. n.s. p>0.05, * p<0.05, ** p<0.01, *** p<0.001 (all against HC)

Mentions: All the clinical subgroups, whether subjects were remitted or unremitted, except for the remitted MDD subgroup, had significantly higher total and social communication and autistic mannerisms subscale scores on the SRS-A compared to the HC group (Fig 2; S3 Table). The remitted MDD subgroup scored significantly lower overall and on the social cognition and social communication subscales relative to the unremitted SZ group, and scored lower on the social motivation subscale than did the unremitted MDD subgroup (as highlighted in S3 Table).


Autistic-like traits in adult patients with mood disorders and schizophrenia.

Matsuo J, Kamio Y, Takahashi H, Ota M, Teraishi T, Hori H, Nagashima A, Takei R, Higuchi T, Motohashi N, Kunugi H - PLoS ONE (2015)

Comparison of the degree of ALTs among the 7 subgroups.SRS-A total scores were compared among the 7 subgroups (i.e., HC and remitted/unremitted MDD, BPD and SZ) using Kruskal Wallis test; Dunn's test was used for further pair-wise multiple comparison. Results of pair-wise comparison between each clinical subgroup and HC are shown with error bar showing quartile deviation. HC: healthy control. MDD: major depressive disorder. BPD: bipolar disorder. SZ: schizophrenia. R: remitted. U: unremitted. n.s. p>0.05, * p<0.05, ** p<0.01, *** p<0.001 (all against HC)
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383414&req=5

pone.0122711.g002: Comparison of the degree of ALTs among the 7 subgroups.SRS-A total scores were compared among the 7 subgroups (i.e., HC and remitted/unremitted MDD, BPD and SZ) using Kruskal Wallis test; Dunn's test was used for further pair-wise multiple comparison. Results of pair-wise comparison between each clinical subgroup and HC are shown with error bar showing quartile deviation. HC: healthy control. MDD: major depressive disorder. BPD: bipolar disorder. SZ: schizophrenia. R: remitted. U: unremitted. n.s. p>0.05, * p<0.05, ** p<0.01, *** p<0.001 (all against HC)
Mentions: All the clinical subgroups, whether subjects were remitted or unremitted, except for the remitted MDD subgroup, had significantly higher total and social communication and autistic mannerisms subscale scores on the SRS-A compared to the HC group (Fig 2; S3 Table). The remitted MDD subgroup scored significantly lower overall and on the social cognition and social communication subscales relative to the unremitted SZ group, and scored lower on the social motivation subscale than did the unremitted MDD subgroup (as highlighted in S3 Table).

Bottom Line: On the other hand, remitted subjects with MDD did not differ from healthy controls with regard to the prevalence or degree of high autistic-like traits/symptoms.Conversely, autistic-like traits among subjects with MDD were associated with the depressive symptom severity.These findings suggest the importance of evaluating autistic-like traits/symptoms underlying adult-onset psychiatric disorders for the best-suited treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan; Department of Neuropsychiatry, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan.

ABSTRACT
Autism spectrum disorder often co-occurs with other psychiatric disorders. Although a high prevalence of autistic-like traits/symptoms has been identified in the pediatric psychiatric population of normal intelligence, there are no reports from adult psychiatric population. This study examined whether there is a greater prevalence of autistic-like traits/symptoms in patients with adult-onset psychiatric disorders such as major depressive disorder (MDD), bipolar disorder, or schizophrenia, and whether such an association is independent of symptom severity. The subjects were 290 adults of normal intelligence between 25 and 59 years of age (MDD, n=125; bipolar disorder, n=56; schizophrenia, n=44; healthy controls, n=65). Autistic-like traits/symptoms were measured using the Social Responsiveness Scale for Adults. Symptom severity was measured using the Positive and Negative Symptoms Scale, the Hamilton Depression Rating Scale, and/or the Young Mania Rating Scale. Almost half of the clinical subjects, except those with remitted MDD, exhibited autistic-like traits/symptoms at levels typical for sub-threshold or threshold autism spectrum disorder. Furthermore, the proportion of psychiatric patients that demonstrated high autistic-like traits/symptoms was significantly greater than that of healthy controls, and not different between that of remitted or unremitted subjects with bipolar disorder or schizophrenia. On the other hand, remitted subjects with MDD did not differ from healthy controls with regard to the prevalence or degree of high autistic-like traits/symptoms. A substantial proportion of adults with bipolar disorder and schizophrenia showed high autistic-like traits/symptoms independent of symptom severity, suggesting a shared pathophysiology among autism spectrum disorder and these psychiatric disorders. Conversely, autistic-like traits among subjects with MDD were associated with the depressive symptom severity. These findings suggest the importance of evaluating autistic-like traits/symptoms underlying adult-onset psychiatric disorders for the best-suited treatment. Further studies with a prospective design and larger samples are needed.

No MeSH data available.


Related in: MedlinePlus