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Diagnostic value of MRI proton density fat fraction for assessing liver steatosis in chronic viral C hepatitis.

Paparo F, Cenderello G, Revelli M, Bacigalupo L, Rutigliani M, Zefiro D, Cevasco L, Amico M, Bandelloni R, Cassola G, Forni GL, Rollandi GA - Biomed Res Int (2015)

Bottom Line: The median MRI PDFF showed a strong correlation with the histological fat fraction (FF) (r = 0.754, 95% CI 0.637 to 0.836, P < 0.0001), and the correlation was influenced by neither the liver stiffness nor the T2* decay.The median MRI PDFF result was significantly lower in the F4 subgroup (P < 0.05).Our MRI technique of PDFF estimation allowed discriminating with a good diagnostic accuracy between different grades of hepatic steatosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, E.O. Ospedali Galliera, Mura della Cappuccine 14, 16128 Genoa, Italy.

ABSTRACT

Objective: To assess the diagnostic performance of a T1-independent, T2*-corrected multiecho magnetic resonance imaging (MRI) technique for the quantification of hepatic steatosis in a cohort of patients affected by chronic viral C hepatitis, using liver biopsy as gold standard.

Methods: Eighty-one untreated patients with chronic viral C hepatitis were prospectively enrolled. All included patients underwent MRI, transient elastography, and liver biopsy within a time interval <10 days.

Results: Our cohort of 77 patients included 43/77 (55.8%) males and 34/77 (44.2%) females with a mean age of 51.31 ± 11.27 (18-81) years. The median MRI PDFF showed a strong correlation with the histological fat fraction (FF) (r = 0.754, 95% CI 0.637 to 0.836, P < 0.0001), and the correlation was influenced by neither the liver stiffness nor the T2* decay. The median MRI PDFF result was significantly lower in the F4 subgroup (P < 0.05). The diagnostic accuracy of MRI PDFF evaluated by AUC-ROC analysis was 0.926 (95% CI 0.843 to 0.973) for S ≥ 1 and 0.929 (95% CI 0.847 to 0.975) for S = 2.

Conclusions: Our MRI technique of PDFF estimation allowed discriminating with a good diagnostic accuracy between different grades of hepatic steatosis.

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Related in: MedlinePlus

ROC curve analysis of MRI PDFF for patients with steatosis S ≥ 1 (S0 versus S1-S2). The area under the ROC curve is 0.926 (95% CI 0.74–0.94) (a). ROC curve analysis of MRI PDFF for patients with steatosis S = 2 (S0-S1 versus S2). The area under the ROC curve is 0.929 (95% CI 0.806 to 0.968) (b).
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fig5: ROC curve analysis of MRI PDFF for patients with steatosis S ≥ 1 (S0 versus S1-S2). The area under the ROC curve is 0.926 (95% CI 0.74–0.94) (a). ROC curve analysis of MRI PDFF for patients with steatosis S = 2 (S0-S1 versus S2). The area under the ROC curve is 0.929 (95% CI 0.806 to 0.968) (b).

Mentions: The diagnostic accuracy of MRI PDFF evaluated by AUC-ROC analysis was 0.926 (standard error 0.0354, 95% CI 0.843 to 0.973) for S ≥ 1 and 0.929 (standard error 0.0363, 95% CI 0.847 to 0.975) for S = 2. The best MRI PDFF cutoff value to differentiate between S0 and S1-S2 patients was 6.87, showing a sensitivity of 87.10% (95% CI 70.2–96.4), a specificity of 97.83 (95% CI 88.5–99.9%), a positive predictive value (PPV) of 96.4% (95% CI 81.7–99.9), and a negative predictive value (NPV) of 91.8% (95% CI 80.4–97.7) (Figure 5(a)). The best MRI PDFF cutoff value to differentiate between S0-S1 and S2 patients was 11.08, showing a sensitivity of 87.5% (95% CI 47.3–99.7), a specificity of 88.41% (95% CI 78.4–94.9), a positive predictive value (PPV) of 46.7% (95% CI 20.5–74.3), and a negative predictive value (NPV) of 98.4% (95% CI 91.3–100) (Figure 5(b)).


Diagnostic value of MRI proton density fat fraction for assessing liver steatosis in chronic viral C hepatitis.

Paparo F, Cenderello G, Revelli M, Bacigalupo L, Rutigliani M, Zefiro D, Cevasco L, Amico M, Bandelloni R, Cassola G, Forni GL, Rollandi GA - Biomed Res Int (2015)

ROC curve analysis of MRI PDFF for patients with steatosis S ≥ 1 (S0 versus S1-S2). The area under the ROC curve is 0.926 (95% CI 0.74–0.94) (a). ROC curve analysis of MRI PDFF for patients with steatosis S = 2 (S0-S1 versus S2). The area under the ROC curve is 0.929 (95% CI 0.806 to 0.968) (b).
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4383409&req=5

fig5: ROC curve analysis of MRI PDFF for patients with steatosis S ≥ 1 (S0 versus S1-S2). The area under the ROC curve is 0.926 (95% CI 0.74–0.94) (a). ROC curve analysis of MRI PDFF for patients with steatosis S = 2 (S0-S1 versus S2). The area under the ROC curve is 0.929 (95% CI 0.806 to 0.968) (b).
Mentions: The diagnostic accuracy of MRI PDFF evaluated by AUC-ROC analysis was 0.926 (standard error 0.0354, 95% CI 0.843 to 0.973) for S ≥ 1 and 0.929 (standard error 0.0363, 95% CI 0.847 to 0.975) for S = 2. The best MRI PDFF cutoff value to differentiate between S0 and S1-S2 patients was 6.87, showing a sensitivity of 87.10% (95% CI 70.2–96.4), a specificity of 97.83 (95% CI 88.5–99.9%), a positive predictive value (PPV) of 96.4% (95% CI 81.7–99.9), and a negative predictive value (NPV) of 91.8% (95% CI 80.4–97.7) (Figure 5(a)). The best MRI PDFF cutoff value to differentiate between S0-S1 and S2 patients was 11.08, showing a sensitivity of 87.5% (95% CI 47.3–99.7), a specificity of 88.41% (95% CI 78.4–94.9), a positive predictive value (PPV) of 46.7% (95% CI 20.5–74.3), and a negative predictive value (NPV) of 98.4% (95% CI 91.3–100) (Figure 5(b)).

Bottom Line: The median MRI PDFF showed a strong correlation with the histological fat fraction (FF) (r = 0.754, 95% CI 0.637 to 0.836, P < 0.0001), and the correlation was influenced by neither the liver stiffness nor the T2* decay.The median MRI PDFF result was significantly lower in the F4 subgroup (P < 0.05).Our MRI technique of PDFF estimation allowed discriminating with a good diagnostic accuracy between different grades of hepatic steatosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, E.O. Ospedali Galliera, Mura della Cappuccine 14, 16128 Genoa, Italy.

ABSTRACT

Objective: To assess the diagnostic performance of a T1-independent, T2*-corrected multiecho magnetic resonance imaging (MRI) technique for the quantification of hepatic steatosis in a cohort of patients affected by chronic viral C hepatitis, using liver biopsy as gold standard.

Methods: Eighty-one untreated patients with chronic viral C hepatitis were prospectively enrolled. All included patients underwent MRI, transient elastography, and liver biopsy within a time interval <10 days.

Results: Our cohort of 77 patients included 43/77 (55.8%) males and 34/77 (44.2%) females with a mean age of 51.31 ± 11.27 (18-81) years. The median MRI PDFF showed a strong correlation with the histological fat fraction (FF) (r = 0.754, 95% CI 0.637 to 0.836, P < 0.0001), and the correlation was influenced by neither the liver stiffness nor the T2* decay. The median MRI PDFF result was significantly lower in the F4 subgroup (P < 0.05). The diagnostic accuracy of MRI PDFF evaluated by AUC-ROC analysis was 0.926 (95% CI 0.843 to 0.973) for S ≥ 1 and 0.929 (95% CI 0.847 to 0.975) for S = 2.

Conclusions: Our MRI technique of PDFF estimation allowed discriminating with a good diagnostic accuracy between different grades of hepatic steatosis.

Show MeSH
Related in: MedlinePlus