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The global ecology and epidemiology of West Nile virus.

Chancey C, Grinev A, Volkova E, Rios M - Biomed Res Int (2015)

Bottom Line: The mosquito vectors for WNV are widely distributed worldwide, and the known geographic range of WNV transmission and disease has continued to increase over the past 77 years.While most human infections with WNV are asymptomatic, severe neurological disease may develop resulting in long-term sequelae or death.Surveillance and preventive measures are an ongoing need to reduce the public health impact of WNV in areas with the potential for transmission.

View Article: PubMed Central - PubMed

Affiliation: United States Food and Drug Administration, Center for Biologics Evaluation and Research, Silver Spring, MD 20993-0002, USA.

ABSTRACT
Since its initial isolation in Uganda in 1937 through the present, West Nile virus (WNV) has become an important cause of human and animal disease worldwide. WNV, an enveloped virus of the genus Flavivirus, is naturally maintained in an enzootic cycle between birds and mosquitoes, with occasional epizootic spillover causing disease in humans and horses. The mosquito vectors for WNV are widely distributed worldwide, and the known geographic range of WNV transmission and disease has continued to increase over the past 77 years. While most human infections with WNV are asymptomatic, severe neurological disease may develop resulting in long-term sequelae or death. Surveillance and preventive measures are an ongoing need to reduce the public health impact of WNV in areas with the potential for transmission.

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Related in: MedlinePlus

(a) Neuroinvasive and nonneuroinvasive cases of WNV in the United States reported to the CDC, 1999–2013. (b) Deaths from WNV infection in the United States reported to the CDC, 1999–2013.
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fig5: (a) Neuroinvasive and nonneuroinvasive cases of WNV in the United States reported to the CDC, 1999–2013. (b) Deaths from WNV infection in the United States reported to the CDC, 1999–2013.

Mentions: The intensity of WNV activity in the U.S. was very high between 2002 and 2007, with over 1,000 WNND cases per year. A decline in the number of cases began in 2008, and comparatively low activity continued through 2011 when only 712 total WNV cases were reported. In 2012, however, another large outbreak of WNV occurred in the U.S., causing 2,873 WNND cases and the most deaths [277] ever reported in a single WNV season. Activity in the U.S. in 2013 was moderate, with 1,267 WNND cases and 119 deaths in 2013 reported as of May 9, 2014. From 1999–2013, there have been a total of 39,557 reported cases of WNV in the U.S. of which 17,381 were WNND, resulting in 1,667 deaths, an average of 111.1 deaths/year [278] (Figure 5).


The global ecology and epidemiology of West Nile virus.

Chancey C, Grinev A, Volkova E, Rios M - Biomed Res Int (2015)

(a) Neuroinvasive and nonneuroinvasive cases of WNV in the United States reported to the CDC, 1999–2013. (b) Deaths from WNV infection in the United States reported to the CDC, 1999–2013.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383390&req=5

fig5: (a) Neuroinvasive and nonneuroinvasive cases of WNV in the United States reported to the CDC, 1999–2013. (b) Deaths from WNV infection in the United States reported to the CDC, 1999–2013.
Mentions: The intensity of WNV activity in the U.S. was very high between 2002 and 2007, with over 1,000 WNND cases per year. A decline in the number of cases began in 2008, and comparatively low activity continued through 2011 when only 712 total WNV cases were reported. In 2012, however, another large outbreak of WNV occurred in the U.S., causing 2,873 WNND cases and the most deaths [277] ever reported in a single WNV season. Activity in the U.S. in 2013 was moderate, with 1,267 WNND cases and 119 deaths in 2013 reported as of May 9, 2014. From 1999–2013, there have been a total of 39,557 reported cases of WNV in the U.S. of which 17,381 were WNND, resulting in 1,667 deaths, an average of 111.1 deaths/year [278] (Figure 5).

Bottom Line: The mosquito vectors for WNV are widely distributed worldwide, and the known geographic range of WNV transmission and disease has continued to increase over the past 77 years.While most human infections with WNV are asymptomatic, severe neurological disease may develop resulting in long-term sequelae or death.Surveillance and preventive measures are an ongoing need to reduce the public health impact of WNV in areas with the potential for transmission.

View Article: PubMed Central - PubMed

Affiliation: United States Food and Drug Administration, Center for Biologics Evaluation and Research, Silver Spring, MD 20993-0002, USA.

ABSTRACT
Since its initial isolation in Uganda in 1937 through the present, West Nile virus (WNV) has become an important cause of human and animal disease worldwide. WNV, an enveloped virus of the genus Flavivirus, is naturally maintained in an enzootic cycle between birds and mosquitoes, with occasional epizootic spillover causing disease in humans and horses. The mosquito vectors for WNV are widely distributed worldwide, and the known geographic range of WNV transmission and disease has continued to increase over the past 77 years. While most human infections with WNV are asymptomatic, severe neurological disease may develop resulting in long-term sequelae or death. Surveillance and preventive measures are an ongoing need to reduce the public health impact of WNV in areas with the potential for transmission.

Show MeSH
Related in: MedlinePlus