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Exercise training and calorie restriction influence the metabolic parameters in ovariectomized female rats.

Pósa A, Szabó R, Kupai K, Csonka A, Szalai Z, Veszelka M, Török S, Daruka L, Varga C - Oxid Med Cell Longev (2015)

Bottom Line: The exercise training combined with the CR resulted in improvements in the glucose tolerance and the insulin sensitivity.Plasma TG, AST, and ALT levels were significantly higher in OVX rats fed with HT but these high values were suppressed by exercise and CR.Our data provide evidence that CR combined with voluntary physical exercise can be a very effective strategy to prevent the development of a metabolic syndrome induced by high calorie diet.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, Anatomy and Neuroscience, University of Szeged, Kozep Fasor 52, Szeged 6726, Hungary.

ABSTRACT
The estrogen deficiency after menopause leads to overweight or obesity, and physical exercise is one of the important modulators of this body weight gain. Female Wistar rats underwent ovariectomy surgery (OVX) or sham operation (SO). OVX and SO groups were randomized into new groups based on the voluntary physical activity (with or without running) and the type of diet for 12 weeks. Rats were fed standard chow (CTRL), high triglyceride diet (HT), or restricted diet (CR). The metabolic syndrome was assessed by measuring the body weight gain, the glucose sensitivity, and the levels of insulin, triglyceride, leptin, and aspartate aminotransferase transaminase (AST) and alanine aminotransferase (ALT). The exercise training combined with the CR resulted in improvements in the glucose tolerance and the insulin sensitivity. Plasma TG, AST, and ALT levels were significantly higher in OVX rats fed with HT but these high values were suppressed by exercise and CR. Compared to SO animals, estrogen deprivation with HT caused a significant increase in leptin level. Our data provide evidence that CR combined with voluntary physical exercise can be a very effective strategy to prevent the development of a metabolic syndrome induced by high calorie diet.

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Related in: MedlinePlus

Effects of 12-week wheel-running exercise and nutrition on the plasma levels of triglyceride (expressed in mmol/L). Results are shown as means ± S.E.M. n = 12. Statistical significance: *P < 0.05 relative to the SO CTRL group, and #P < 0.05 is the significant difference between the running (R) and nonrunning groups. SO = sham-operated, OVX = ovariectomized, CTRL = standard chow, CR = calorie restriction, and HT = high-triglyceride.
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fig3: Effects of 12-week wheel-running exercise and nutrition on the plasma levels of triglyceride (expressed in mmol/L). Results are shown as means ± S.E.M. n = 12. Statistical significance: *P < 0.05 relative to the SO CTRL group, and #P < 0.05 is the significant difference between the running (R) and nonrunning groups. SO = sham-operated, OVX = ovariectomized, CTRL = standard chow, CR = calorie restriction, and HT = high-triglyceride.

Mentions: Figure 3 shows the plasma levels of TG measured by ELISA. The highest TG levels were observed in both the SO (42%, P < 0.05) and the OVX rats (45%, P < 0.05) fed with the HT diet and were significantly higher as compared with the SO CTRL subgroup. However, the combined effects of the 12-week exercise and the CR decreasing the TG levels only in the OVX animals (33%, P < 0.05) and the exercise training alone were also effective in the OVX HT subgroup (44%, P < 0.05).


Exercise training and calorie restriction influence the metabolic parameters in ovariectomized female rats.

Pósa A, Szabó R, Kupai K, Csonka A, Szalai Z, Veszelka M, Török S, Daruka L, Varga C - Oxid Med Cell Longev (2015)

Effects of 12-week wheel-running exercise and nutrition on the plasma levels of triglyceride (expressed in mmol/L). Results are shown as means ± S.E.M. n = 12. Statistical significance: *P < 0.05 relative to the SO CTRL group, and #P < 0.05 is the significant difference between the running (R) and nonrunning groups. SO = sham-operated, OVX = ovariectomized, CTRL = standard chow, CR = calorie restriction, and HT = high-triglyceride.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4383370&req=5

fig3: Effects of 12-week wheel-running exercise and nutrition on the plasma levels of triglyceride (expressed in mmol/L). Results are shown as means ± S.E.M. n = 12. Statistical significance: *P < 0.05 relative to the SO CTRL group, and #P < 0.05 is the significant difference between the running (R) and nonrunning groups. SO = sham-operated, OVX = ovariectomized, CTRL = standard chow, CR = calorie restriction, and HT = high-triglyceride.
Mentions: Figure 3 shows the plasma levels of TG measured by ELISA. The highest TG levels were observed in both the SO (42%, P < 0.05) and the OVX rats (45%, P < 0.05) fed with the HT diet and were significantly higher as compared with the SO CTRL subgroup. However, the combined effects of the 12-week exercise and the CR decreasing the TG levels only in the OVX animals (33%, P < 0.05) and the exercise training alone were also effective in the OVX HT subgroup (44%, P < 0.05).

Bottom Line: The exercise training combined with the CR resulted in improvements in the glucose tolerance and the insulin sensitivity.Plasma TG, AST, and ALT levels were significantly higher in OVX rats fed with HT but these high values were suppressed by exercise and CR.Our data provide evidence that CR combined with voluntary physical exercise can be a very effective strategy to prevent the development of a metabolic syndrome induced by high calorie diet.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, Anatomy and Neuroscience, University of Szeged, Kozep Fasor 52, Szeged 6726, Hungary.

ABSTRACT
The estrogen deficiency after menopause leads to overweight or obesity, and physical exercise is one of the important modulators of this body weight gain. Female Wistar rats underwent ovariectomy surgery (OVX) or sham operation (SO). OVX and SO groups were randomized into new groups based on the voluntary physical activity (with or without running) and the type of diet for 12 weeks. Rats were fed standard chow (CTRL), high triglyceride diet (HT), or restricted diet (CR). The metabolic syndrome was assessed by measuring the body weight gain, the glucose sensitivity, and the levels of insulin, triglyceride, leptin, and aspartate aminotransferase transaminase (AST) and alanine aminotransferase (ALT). The exercise training combined with the CR resulted in improvements in the glucose tolerance and the insulin sensitivity. Plasma TG, AST, and ALT levels were significantly higher in OVX rats fed with HT but these high values were suppressed by exercise and CR. Compared to SO animals, estrogen deprivation with HT caused a significant increase in leptin level. Our data provide evidence that CR combined with voluntary physical exercise can be a very effective strategy to prevent the development of a metabolic syndrome induced by high calorie diet.

Show MeSH
Related in: MedlinePlus