Advances in the behavioural testing and network imaging of rodent recognition memory.
Bottom Line: The standard task, however, contains a number of inherent shortcomings that reduce its power.In contrast, when familiar objects are explored the pathway from the perirhinal cortex to lateral entorhinal cortex, and then to CA1, takes precedence.The switch to the perforant pathway (novel stimuli) from the temporoammonic pathway (familiar stimuli) may assist the enhanced associative learning promoted by novel stimuli.
Affiliation: School of Psychology, Cardiff University, Tower Building, 70 Park Place, Cardiff, Wales CF10 3AT, United Kingdom. Electronic address: firstname.lastname@example.org.Show MeSH
Related in: MedlinePlus
Mentions: There is a need to devise a task that utilises the strongest features of the spontaneous object recognition task while addressing as many of its shortcomings as possible. The ‘bow-tie maze’, introduced by Albasser et al. , was designed for this very reason. This task is a hybrid of DNMS and spontaneous object recognition, drawing key elements from both tasks. The central feature is that rodents repeatedly explore pairs of objects at opposite ends of an enclosed maze shaped like a bow-tie. Each pair of stimuli consists of one novel object and one familiar object (Fig. 2A and B). A sliding door in the middle of the maze separates the two ends of the maze, so ensuring discrete trials. This arrangement makes it possible to run multiple trials within a session without handling the rodents. Although the animals have to be pre-trained to run from one end of the maze to the other for food rewards, which adds to the labour involved, this pre-training helps to ensure that the animals are well habituated to the test environment and so reduces stress.
Affiliation: School of Psychology, Cardiff University, Tower Building, 70 Park Place, Cardiff, Wales CF10 3AT, United Kingdom. Electronic address: email@example.com.