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Neural circuitry for rat recognition memory.

Warburton EC, Brown MW - Behav. Brain Res. (2014)

Bottom Line: Information concerning the roles of different brain regions in recognition memory processes is reviewed.Particular emphasis is given to the potential roles of different regions in the circuit of interacting structures involving the perirhinal cortex, hippocampus, medial prefrontal cortex and medial dorsal thalamus in recognition memory for the association of objects and places.It is concluded that while all structures in this circuit play roles critical to such memory, these roles can potentially be differentiated and differences in the underlying synaptic and biochemical processes involved in each region are beginning to be uncovered.

View Article: PubMed Central - PubMed

Affiliation: School of Physiology and Pharmacology, University of Bristol, Medical Sciences Building, University Walk, Bristol BS8 1TD, United Kingdom. Electronic address: e.c.warburton@bristol.ac.uk.

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Schematic diagram of the main pathways underlying object recognition memory that involves multiple items and their contextual associations or the temporal order in which items are encountered.
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fig0010: Schematic diagram of the main pathways underlying object recognition memory that involves multiple items and their contextual associations or the temporal order in which items are encountered.

Mentions: Using this experimental strategy it was found that disconnection of the medial prefrontal cortex from the perirhinal cortex disrupted both object-in-place and temporal order memory, while having no effect on single item recognition or object location memory: crossed lesions resulted in major deficits in both object-in-place and temporal order memory while unilateral lesions were without effect [22]. Similarly, disconnection of the medial prefrontal cortex or perirhinal cortex from the hippocampus impaired object-in-place and temporal order but not single-tem recognition or object location memory [10,85]. Together these results established that both object-in-place and temporal order recognition memory depend on a hippocampal–medial prefrontal–perirhinal cortex circuit (Fig. 2). Interactions between all of these structures are clearly necessary for object-in-place and temporal order memory.


Neural circuitry for rat recognition memory.

Warburton EC, Brown MW - Behav. Brain Res. (2014)

Schematic diagram of the main pathways underlying object recognition memory that involves multiple items and their contextual associations or the temporal order in which items are encountered.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383363&req=5

fig0010: Schematic diagram of the main pathways underlying object recognition memory that involves multiple items and their contextual associations or the temporal order in which items are encountered.
Mentions: Using this experimental strategy it was found that disconnection of the medial prefrontal cortex from the perirhinal cortex disrupted both object-in-place and temporal order memory, while having no effect on single item recognition or object location memory: crossed lesions resulted in major deficits in both object-in-place and temporal order memory while unilateral lesions were without effect [22]. Similarly, disconnection of the medial prefrontal cortex or perirhinal cortex from the hippocampus impaired object-in-place and temporal order but not single-tem recognition or object location memory [10,85]. Together these results established that both object-in-place and temporal order recognition memory depend on a hippocampal–medial prefrontal–perirhinal cortex circuit (Fig. 2). Interactions between all of these structures are clearly necessary for object-in-place and temporal order memory.

Bottom Line: Information concerning the roles of different brain regions in recognition memory processes is reviewed.Particular emphasis is given to the potential roles of different regions in the circuit of interacting structures involving the perirhinal cortex, hippocampus, medial prefrontal cortex and medial dorsal thalamus in recognition memory for the association of objects and places.It is concluded that while all structures in this circuit play roles critical to such memory, these roles can potentially be differentiated and differences in the underlying synaptic and biochemical processes involved in each region are beginning to be uncovered.

View Article: PubMed Central - PubMed

Affiliation: School of Physiology and Pharmacology, University of Bristol, Medical Sciences Building, University Walk, Bristol BS8 1TD, United Kingdom. Electronic address: e.c.warburton@bristol.ac.uk.

Show MeSH
Related in: MedlinePlus