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Blood brain barrier: a challenge for effectual therapy of brain tumors.

Bhowmik A, Khan R, Ghosh MK - Biomed Res Int (2015)

Bottom Line: They have only a fair to poor prognosis and high relapse rate.One of the major causes of extreme difficulty in brain tumor treatment is the presence of blood brain barrier (BBB).Thus, along with the conventional techniques, successful modification of drug delivery and novel therapeutic strategies are needed to overcome this obstacle for treatment of brain tumors.

View Article: PubMed Central - PubMed

Affiliation: Signal Transduction in Cancer and Stem Cells Laboratory, Division of Cancer Biology and Inflammatory Disorder, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology (CSIR-IICB), 4 Raja S.C. Mullick Road, Jadavpur, Kolkata 700 032, India.

ABSTRACT
Brain tumors are one of the most formidable diseases of mankind. They have only a fair to poor prognosis and high relapse rate. One of the major causes of extreme difficulty in brain tumor treatment is the presence of blood brain barrier (BBB). BBB comprises different molecular components and transport systems, which in turn create efflux machinery or hindrance for the entry of several drugs in brain. Thus, along with the conventional techniques, successful modification of drug delivery and novel therapeutic strategies are needed to overcome this obstacle for treatment of brain tumors. In this review, we have elucidated some critical insights into the composition and function of BBB and along with it we have discussed the effective methods for delivery of drugs to the brain and therapeutic strategies overcoming the barrier.

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A pictorial representation of the BBB and its tight junction structure. The figure shows an irrigated blood vessel in the brain which forms the BBB. The BBB is constituted by endothelial cells with tight junctions, surrounded by pericytes and astrocytic end-feet. The tight junction is further established by the interaction of proteins like claudins, occludin, junction adhesion molecules, and cytoplasmic accessory proteins (ZO1, ZO2, and ZO3) of adjacent endothelial cells. The details of each component of the BBB are mentioned in the text of this review.
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fig1: A pictorial representation of the BBB and its tight junction structure. The figure shows an irrigated blood vessel in the brain which forms the BBB. The BBB is constituted by endothelial cells with tight junctions, surrounded by pericytes and astrocytic end-feet. The tight junction is further established by the interaction of proteins like claudins, occludin, junction adhesion molecules, and cytoplasmic accessory proteins (ZO1, ZO2, and ZO3) of adjacent endothelial cells. The details of each component of the BBB are mentioned in the text of this review.

Mentions: Molecular character of BBB shows the presence of two types of cellular junctions, the intercellular adherens junction and the paracellular tight junction. The functional integrity of BBB is maintained by adherens junction that is composed of vascular endothelium (VE), cadherin, actinin, and catenin [22]. But the major functionality of BBB is maintained by tight junctions, as they are primarily responsible for permeability through BBB [23, 24]. The BBB in adult is comprised of a complex cellular network. The main components of this system are brain endothelial cells, highly specialized basal membrane, a plenty of pericytes embedded in the basal membrane, and astrocytic end-feet (see Figure 1).


Blood brain barrier: a challenge for effectual therapy of brain tumors.

Bhowmik A, Khan R, Ghosh MK - Biomed Res Int (2015)

A pictorial representation of the BBB and its tight junction structure. The figure shows an irrigated blood vessel in the brain which forms the BBB. The BBB is constituted by endothelial cells with tight junctions, surrounded by pericytes and astrocytic end-feet. The tight junction is further established by the interaction of proteins like claudins, occludin, junction adhesion molecules, and cytoplasmic accessory proteins (ZO1, ZO2, and ZO3) of adjacent endothelial cells. The details of each component of the BBB are mentioned in the text of this review.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383356&req=5

fig1: A pictorial representation of the BBB and its tight junction structure. The figure shows an irrigated blood vessel in the brain which forms the BBB. The BBB is constituted by endothelial cells with tight junctions, surrounded by pericytes and astrocytic end-feet. The tight junction is further established by the interaction of proteins like claudins, occludin, junction adhesion molecules, and cytoplasmic accessory proteins (ZO1, ZO2, and ZO3) of adjacent endothelial cells. The details of each component of the BBB are mentioned in the text of this review.
Mentions: Molecular character of BBB shows the presence of two types of cellular junctions, the intercellular adherens junction and the paracellular tight junction. The functional integrity of BBB is maintained by adherens junction that is composed of vascular endothelium (VE), cadherin, actinin, and catenin [22]. But the major functionality of BBB is maintained by tight junctions, as they are primarily responsible for permeability through BBB [23, 24]. The BBB in adult is comprised of a complex cellular network. The main components of this system are brain endothelial cells, highly specialized basal membrane, a plenty of pericytes embedded in the basal membrane, and astrocytic end-feet (see Figure 1).

Bottom Line: They have only a fair to poor prognosis and high relapse rate.One of the major causes of extreme difficulty in brain tumor treatment is the presence of blood brain barrier (BBB).Thus, along with the conventional techniques, successful modification of drug delivery and novel therapeutic strategies are needed to overcome this obstacle for treatment of brain tumors.

View Article: PubMed Central - PubMed

Affiliation: Signal Transduction in Cancer and Stem Cells Laboratory, Division of Cancer Biology and Inflammatory Disorder, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology (CSIR-IICB), 4 Raja S.C. Mullick Road, Jadavpur, Kolkata 700 032, India.

ABSTRACT
Brain tumors are one of the most formidable diseases of mankind. They have only a fair to poor prognosis and high relapse rate. One of the major causes of extreme difficulty in brain tumor treatment is the presence of blood brain barrier (BBB). BBB comprises different molecular components and transport systems, which in turn create efflux machinery or hindrance for the entry of several drugs in brain. Thus, along with the conventional techniques, successful modification of drug delivery and novel therapeutic strategies are needed to overcome this obstacle for treatment of brain tumors. In this review, we have elucidated some critical insights into the composition and function of BBB and along with it we have discussed the effective methods for delivery of drugs to the brain and therapeutic strategies overcoming the barrier.

Show MeSH
Related in: MedlinePlus