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The formation of biofilms by Pseudomonas aeruginosa: a review of the natural and synthetic compounds interfering with control mechanisms.

Rasamiravaka T, Labtani Q, Duez P, El Jaziri M - Biomed Res Int (2015)

Bottom Line: Beyond its natural resistance to many drugs, its ability to form biofilm, a complex biological system, renders ineffective the clearance by immune defense systems and antibiotherapy.The objective of this report is to provide an overview (i) on P. aeruginosa biofilm lifestyle cycle, (ii) on the main key actors relevant in the regulation of biofilm formation by P. aeruginosa including QS systems, GacS/GacA and RetS/LadS two-component systems and C-di-GMP-dependent polysaccharides biosynthesis, and (iii) finally on reported natural and synthetic products that interfere with control mechanisms of biofilm formation by P. aeruginosa without affecting directly bacterial viability.Concluding remarks focus on perspectives to consider biofilm lifestyle as a target for eradication of resistant infections caused by P. aeruginosa.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Plant Biotechnology, Université Libre de Bruxelles, rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium.

ABSTRACT
P. aeruginosa is an opportunistic pathogenic bacterium responsible for both acute and chronic infections. Beyond its natural resistance to many drugs, its ability to form biofilm, a complex biological system, renders ineffective the clearance by immune defense systems and antibiotherapy. The objective of this report is to provide an overview (i) on P. aeruginosa biofilm lifestyle cycle, (ii) on the main key actors relevant in the regulation of biofilm formation by P. aeruginosa including QS systems, GacS/GacA and RetS/LadS two-component systems and C-di-GMP-dependent polysaccharides biosynthesis, and (iii) finally on reported natural and synthetic products that interfere with control mechanisms of biofilm formation by P. aeruginosa without affecting directly bacterial viability. Concluding remarks focus on perspectives to consider biofilm lifestyle as a target for eradication of resistant infections caused by P. aeruginosa.

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Relevant bacterial systems and factors implicated in the regulation of P. aeruginosa biofilm formation. (1) Quorum sensing system; (2) Two-component regulatory system GacS/GacA and RetS/LadS (RR: response regulator domain receiver; P: phosphorylation) pathway; (3) Exopolysaccharides production and c-di-GMP pool regulation. See text for explanation.
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fig2: Relevant bacterial systems and factors implicated in the regulation of P. aeruginosa biofilm formation. (1) Quorum sensing system; (2) Two-component regulatory system GacS/GacA and RetS/LadS (RR: response regulator domain receiver; P: phosphorylation) pathway; (3) Exopolysaccharides production and c-di-GMP pool regulation. See text for explanation.

Mentions: The complex regulation of biofilm formation involves multiple bacterial machineries, including the QS systems and the two-component regulatory systems that both interact mainly with EPS production [52]. Deficiency in the network regulation required for biofilm matrix formation effectively results in the alteration of the biofilm structure and architecture and, therefore, of its protective role. The main key actors relevant in the regulation of biofilm formation by P. aeruginosa are summarized in Figure 2.


The formation of biofilms by Pseudomonas aeruginosa: a review of the natural and synthetic compounds interfering with control mechanisms.

Rasamiravaka T, Labtani Q, Duez P, El Jaziri M - Biomed Res Int (2015)

Relevant bacterial systems and factors implicated in the regulation of P. aeruginosa biofilm formation. (1) Quorum sensing system; (2) Two-component regulatory system GacS/GacA and RetS/LadS (RR: response regulator domain receiver; P: phosphorylation) pathway; (3) Exopolysaccharides production and c-di-GMP pool regulation. See text for explanation.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383298&req=5

fig2: Relevant bacterial systems and factors implicated in the regulation of P. aeruginosa biofilm formation. (1) Quorum sensing system; (2) Two-component regulatory system GacS/GacA and RetS/LadS (RR: response regulator domain receiver; P: phosphorylation) pathway; (3) Exopolysaccharides production and c-di-GMP pool regulation. See text for explanation.
Mentions: The complex regulation of biofilm formation involves multiple bacterial machineries, including the QS systems and the two-component regulatory systems that both interact mainly with EPS production [52]. Deficiency in the network regulation required for biofilm matrix formation effectively results in the alteration of the biofilm structure and architecture and, therefore, of its protective role. The main key actors relevant in the regulation of biofilm formation by P. aeruginosa are summarized in Figure 2.

Bottom Line: Beyond its natural resistance to many drugs, its ability to form biofilm, a complex biological system, renders ineffective the clearance by immune defense systems and antibiotherapy.The objective of this report is to provide an overview (i) on P. aeruginosa biofilm lifestyle cycle, (ii) on the main key actors relevant in the regulation of biofilm formation by P. aeruginosa including QS systems, GacS/GacA and RetS/LadS two-component systems and C-di-GMP-dependent polysaccharides biosynthesis, and (iii) finally on reported natural and synthetic products that interfere with control mechanisms of biofilm formation by P. aeruginosa without affecting directly bacterial viability.Concluding remarks focus on perspectives to consider biofilm lifestyle as a target for eradication of resistant infections caused by P. aeruginosa.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Plant Biotechnology, Université Libre de Bruxelles, rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium.

ABSTRACT
P. aeruginosa is an opportunistic pathogenic bacterium responsible for both acute and chronic infections. Beyond its natural resistance to many drugs, its ability to form biofilm, a complex biological system, renders ineffective the clearance by immune defense systems and antibiotherapy. The objective of this report is to provide an overview (i) on P. aeruginosa biofilm lifestyle cycle, (ii) on the main key actors relevant in the regulation of biofilm formation by P. aeruginosa including QS systems, GacS/GacA and RetS/LadS two-component systems and C-di-GMP-dependent polysaccharides biosynthesis, and (iii) finally on reported natural and synthetic products that interfere with control mechanisms of biofilm formation by P. aeruginosa without affecting directly bacterial viability. Concluding remarks focus on perspectives to consider biofilm lifestyle as a target for eradication of resistant infections caused by P. aeruginosa.

Show MeSH
Related in: MedlinePlus