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Functionalized scaffolds to enhance tissue regeneration.

Guo B, Lei B, Li P, Ma PX - Regen Biomater (2015)

Bottom Line: It not only provides a temporary 3-dimensional support during tissue repair, but also regulates the cell behavior, such as cell adhesion, proliferation and differentiation.Furthermore, the progress on the fabrication of biomimetic nanofibrous scaffolds from conducting polymers and composites of HA and BG via electrospinning, deposition and thermally induced phase separation is discussed.Moreover, bioactive molecules and surface properties of scaffolds are very important during tissue repair.

View Article: PubMed Central - PubMed

Affiliation: Center for Biomedical Engineering and Regenerative Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.

ABSTRACT

Tissue engineering scaffolds play a vital role in regenerative medicine. It not only provides a temporary 3-dimensional support during tissue repair, but also regulates the cell behavior, such as cell adhesion, proliferation and differentiation. In this review, we summarize the development and trends of functional scaffolding biomaterials including electrically conducting hydrogels and nano-composites of hydroxyapatite (HA) and bioactive glasses (BGs) with various biodegradable polymers. Furthermore, the progress on the fabrication of biomimetic nanofibrous scaffolds from conducting polymers and composites of HA and BG via electrospinning, deposition and thermally induced phase separation is discussed. Moreover, bioactive molecules and surface properties of scaffolds are very important during tissue repair. Bioactive molecule-releasing scaffolds and antimicrobial surface coatings for biomedical implants and scaffolds are also reviewed.

No MeSH data available.


Related in: MedlinePlus

Nanoporous antimicroibial hydrogel coating fabricated by polysaccharides: (A) synthesis of quaternized CS functionalized with acrylate PEG side-chains; (B) formation of nanoporous hydrogel coating which is capable to kill microbes; (C) the cell wall of the Gram-negative bacteria Pseudomonas aeruginosa was disrupted by the nanoporous hydrogel. Reproduced from Ref. [105] with permission from Nature Publishing Group.
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rbu016-F8: Nanoporous antimicroibial hydrogel coating fabricated by polysaccharides: (A) synthesis of quaternized CS functionalized with acrylate PEG side-chains; (B) formation of nanoporous hydrogel coating which is capable to kill microbes; (C) the cell wall of the Gram-negative bacteria Pseudomonas aeruginosa was disrupted by the nanoporous hydrogel. Reproduced from Ref. [105] with permission from Nature Publishing Group.

Mentions: Surface modification by immobilization of AMPs is a promising method to prevent infections. Peptide LL-37 was grafted on titanium surface with a polyethylene glycol spacer by Gabriel et al. [101], which resulted in a surface peptide layer capable of killing bacteria on contact. Zhou and coworkers developed broad-spectrum antimicrobial surface coating by the immobilization of epsilon-poly-l-lysine hydrogel onto biomedical devices [102]. Besides antimicrobial activity, several recent AMP-immobilized surface coatings also show excellent anti-biofilm activities [103, 104]. Recently, Li et al. have developed novel broad-spectrum antimicrobial coating materials based on natural polysaccharides [105, 106]. Firstly, a group of antimicrobial materials were synthesized by quaternization and alkylation of CS. An argon plasma-ultraviolet (UV)-induced coating method for hydrogel surface immobilization was developed, which can be applied on diverse biomedical surfaces. A novel mechanism of these hydrogels based on ‘anion sponge’ concept was proposed and proven (Fig. 8). The optimized coating formulation and conditions show excellent antimicrobial potency. The in vitro and in vivo studies suggest this antimicrobial coating is biocompatible with mammalian cells.Figure 8.


Functionalized scaffolds to enhance tissue regeneration.

Guo B, Lei B, Li P, Ma PX - Regen Biomater (2015)

Nanoporous antimicroibial hydrogel coating fabricated by polysaccharides: (A) synthesis of quaternized CS functionalized with acrylate PEG side-chains; (B) formation of nanoporous hydrogel coating which is capable to kill microbes; (C) the cell wall of the Gram-negative bacteria Pseudomonas aeruginosa was disrupted by the nanoporous hydrogel. Reproduced from Ref. [105] with permission from Nature Publishing Group.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383297&req=5

rbu016-F8: Nanoporous antimicroibial hydrogel coating fabricated by polysaccharides: (A) synthesis of quaternized CS functionalized with acrylate PEG side-chains; (B) formation of nanoporous hydrogel coating which is capable to kill microbes; (C) the cell wall of the Gram-negative bacteria Pseudomonas aeruginosa was disrupted by the nanoporous hydrogel. Reproduced from Ref. [105] with permission from Nature Publishing Group.
Mentions: Surface modification by immobilization of AMPs is a promising method to prevent infections. Peptide LL-37 was grafted on titanium surface with a polyethylene glycol spacer by Gabriel et al. [101], which resulted in a surface peptide layer capable of killing bacteria on contact. Zhou and coworkers developed broad-spectrum antimicrobial surface coating by the immobilization of epsilon-poly-l-lysine hydrogel onto biomedical devices [102]. Besides antimicrobial activity, several recent AMP-immobilized surface coatings also show excellent anti-biofilm activities [103, 104]. Recently, Li et al. have developed novel broad-spectrum antimicrobial coating materials based on natural polysaccharides [105, 106]. Firstly, a group of antimicrobial materials were synthesized by quaternization and alkylation of CS. An argon plasma-ultraviolet (UV)-induced coating method for hydrogel surface immobilization was developed, which can be applied on diverse biomedical surfaces. A novel mechanism of these hydrogels based on ‘anion sponge’ concept was proposed and proven (Fig. 8). The optimized coating formulation and conditions show excellent antimicrobial potency. The in vitro and in vivo studies suggest this antimicrobial coating is biocompatible with mammalian cells.Figure 8.

Bottom Line: It not only provides a temporary 3-dimensional support during tissue repair, but also regulates the cell behavior, such as cell adhesion, proliferation and differentiation.Furthermore, the progress on the fabrication of biomimetic nanofibrous scaffolds from conducting polymers and composites of HA and BG via electrospinning, deposition and thermally induced phase separation is discussed.Moreover, bioactive molecules and surface properties of scaffolds are very important during tissue repair.

View Article: PubMed Central - PubMed

Affiliation: Center for Biomedical Engineering and Regenerative Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.

ABSTRACT

Tissue engineering scaffolds play a vital role in regenerative medicine. It not only provides a temporary 3-dimensional support during tissue repair, but also regulates the cell behavior, such as cell adhesion, proliferation and differentiation. In this review, we summarize the development and trends of functional scaffolding biomaterials including electrically conducting hydrogels and nano-composites of hydroxyapatite (HA) and bioactive glasses (BGs) with various biodegradable polymers. Furthermore, the progress on the fabrication of biomimetic nanofibrous scaffolds from conducting polymers and composites of HA and BG via electrospinning, deposition and thermally induced phase separation is discussed. Moreover, bioactive molecules and surface properties of scaffolds are very important during tissue repair. Bioactive molecule-releasing scaffolds and antimicrobial surface coatings for biomedical implants and scaffolds are also reviewed.

No MeSH data available.


Related in: MedlinePlus