Limits...
Functionalized scaffolds to enhance tissue regeneration.

Guo B, Lei B, Li P, Ma PX - Regen Biomater (2015)

Bottom Line: It not only provides a temporary 3-dimensional support during tissue repair, but also regulates the cell behavior, such as cell adhesion, proliferation and differentiation.Furthermore, the progress on the fabrication of biomimetic nanofibrous scaffolds from conducting polymers and composites of HA and BG via electrospinning, deposition and thermally induced phase separation is discussed.Moreover, bioactive molecules and surface properties of scaffolds are very important during tissue repair.

View Article: PubMed Central - PubMed

Affiliation: Center for Biomedical Engineering and Regenerative Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.

ABSTRACT

Tissue engineering scaffolds play a vital role in regenerative medicine. It not only provides a temporary 3-dimensional support during tissue repair, but also regulates the cell behavior, such as cell adhesion, proliferation and differentiation. In this review, we summarize the development and trends of functional scaffolding biomaterials including electrically conducting hydrogels and nano-composites of hydroxyapatite (HA) and bioactive glasses (BGs) with various biodegradable polymers. Furthermore, the progress on the fabrication of biomimetic nanofibrous scaffolds from conducting polymers and composites of HA and BG via electrospinning, deposition and thermally induced phase separation is discussed. Moreover, bioactive molecules and surface properties of scaffolds are very important during tissue repair. Bioactive molecule-releasing scaffolds and antimicrobial surface coatings for biomedical implants and scaffolds are also reviewed.

No MeSH data available.


Related in: MedlinePlus

Antimicrobial properties of PLA nanofibrous scaffolds treated with Silvadur ET containing 31.25 μg/ml silver against Escherichia coli (A), Staphylococcus aureus (B) and silver-resistant E. coli (C) bacteria as evaluated by the AATCC 147 test [92]. Copyright 2014. With the permission of Elsevier.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4383297&req=5

rbu016-F7: Antimicrobial properties of PLA nanofibrous scaffolds treated with Silvadur ET containing 31.25 μg/ml silver against Escherichia coli (A), Staphylococcus aureus (B) and silver-resistant E. coli (C) bacteria as evaluated by the AATCC 147 test [92]. Copyright 2014. With the permission of Elsevier.

Mentions: During the implantation of scaffolds, even with the help of hygienic technique during the operation, opportunistic microbes still manage to be introduced to the implant sites [84]. Host defenses are often not capable of preventing further colonization if bacterial adhesion occurs before tissue integration at the implant [15, 85]. Antimicrobial modification of scaffolds based on drug-release strategy has been very popular in recent years, and these may be designed to release antimicrobial molecules to inhibit microbial colonization in the surrounding environments. Most commonly, the scaffolds are loaded with antimicrobials such as antibiotics [86, 87], quaternary ammonium compounds [88], heavy metal compounds (e.g. silver, tributyltin and mercury) [89, 90] and halogens (e.g. iodine) [91], which are then slowly released into the environment to kill microbes around. Figure 7 shows PLA nanofibrous scaffolds releasing silver ions which inhibit the bacteria growth [92].Figure 7.


Functionalized scaffolds to enhance tissue regeneration.

Guo B, Lei B, Li P, Ma PX - Regen Biomater (2015)

Antimicrobial properties of PLA nanofibrous scaffolds treated with Silvadur ET containing 31.25 μg/ml silver against Escherichia coli (A), Staphylococcus aureus (B) and silver-resistant E. coli (C) bacteria as evaluated by the AATCC 147 test [92]. Copyright 2014. With the permission of Elsevier.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383297&req=5

rbu016-F7: Antimicrobial properties of PLA nanofibrous scaffolds treated with Silvadur ET containing 31.25 μg/ml silver against Escherichia coli (A), Staphylococcus aureus (B) and silver-resistant E. coli (C) bacteria as evaluated by the AATCC 147 test [92]. Copyright 2014. With the permission of Elsevier.
Mentions: During the implantation of scaffolds, even with the help of hygienic technique during the operation, opportunistic microbes still manage to be introduced to the implant sites [84]. Host defenses are often not capable of preventing further colonization if bacterial adhesion occurs before tissue integration at the implant [15, 85]. Antimicrobial modification of scaffolds based on drug-release strategy has been very popular in recent years, and these may be designed to release antimicrobial molecules to inhibit microbial colonization in the surrounding environments. Most commonly, the scaffolds are loaded with antimicrobials such as antibiotics [86, 87], quaternary ammonium compounds [88], heavy metal compounds (e.g. silver, tributyltin and mercury) [89, 90] and halogens (e.g. iodine) [91], which are then slowly released into the environment to kill microbes around. Figure 7 shows PLA nanofibrous scaffolds releasing silver ions which inhibit the bacteria growth [92].Figure 7.

Bottom Line: It not only provides a temporary 3-dimensional support during tissue repair, but also regulates the cell behavior, such as cell adhesion, proliferation and differentiation.Furthermore, the progress on the fabrication of biomimetic nanofibrous scaffolds from conducting polymers and composites of HA and BG via electrospinning, deposition and thermally induced phase separation is discussed.Moreover, bioactive molecules and surface properties of scaffolds are very important during tissue repair.

View Article: PubMed Central - PubMed

Affiliation: Center for Biomedical Engineering and Regenerative Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.

ABSTRACT

Tissue engineering scaffolds play a vital role in regenerative medicine. It not only provides a temporary 3-dimensional support during tissue repair, but also regulates the cell behavior, such as cell adhesion, proliferation and differentiation. In this review, we summarize the development and trends of functional scaffolding biomaterials including electrically conducting hydrogels and nano-composites of hydroxyapatite (HA) and bioactive glasses (BGs) with various biodegradable polymers. Furthermore, the progress on the fabrication of biomimetic nanofibrous scaffolds from conducting polymers and composites of HA and BG via electrospinning, deposition and thermally induced phase separation is discussed. Moreover, bioactive molecules and surface properties of scaffolds are very important during tissue repair. Bioactive molecule-releasing scaffolds and antimicrobial surface coatings for biomedical implants and scaffolds are also reviewed.

No MeSH data available.


Related in: MedlinePlus