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Functionalized scaffolds to enhance tissue regeneration.

Guo B, Lei B, Li P, Ma PX - Regen Biomater (2015)

Bottom Line: It not only provides a temporary 3-dimensional support during tissue repair, but also regulates the cell behavior, such as cell adhesion, proliferation and differentiation.Furthermore, the progress on the fabrication of biomimetic nanofibrous scaffolds from conducting polymers and composites of HA and BG via electrospinning, deposition and thermally induced phase separation is discussed.Moreover, bioactive molecules and surface properties of scaffolds are very important during tissue repair.

View Article: PubMed Central - PubMed

Affiliation: Center for Biomedical Engineering and Regenerative Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.

ABSTRACT

Tissue engineering scaffolds play a vital role in regenerative medicine. It not only provides a temporary 3-dimensional support during tissue repair, but also regulates the cell behavior, such as cell adhesion, proliferation and differentiation. In this review, we summarize the development and trends of functional scaffolding biomaterials including electrically conducting hydrogels and nano-composites of hydroxyapatite (HA) and bioactive glasses (BGs) with various biodegradable polymers. Furthermore, the progress on the fabrication of biomimetic nanofibrous scaffolds from conducting polymers and composites of HA and BG via electrospinning, deposition and thermally induced phase separation is discussed. Moreover, bioactive molecules and surface properties of scaffolds are very important during tissue repair. Bioactive molecule-releasing scaffolds and antimicrobial surface coatings for biomedical implants and scaffolds are also reviewed.

No MeSH data available.


Related in: MedlinePlus

Functionalized PLA nano-fibrous scaffolds incorporating recombinant human bone morphogenetic protein-7 (rhBMP-7) nanospheres. (A, B) rhBMP-7-loaded nanosphere and scaffolds; (C–F) SEM images of nano-fibrous scaffolds before (C and D) and after nanosphere incorporation (E and F). Reproduced from Ref. [31] with permission from Elsevier.
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rbu016-F6: Functionalized PLA nano-fibrous scaffolds incorporating recombinant human bone morphogenetic protein-7 (rhBMP-7) nanospheres. (A, B) rhBMP-7-loaded nanosphere and scaffolds; (C–F) SEM images of nano-fibrous scaffolds before (C and D) and after nanosphere incorporation (E and F). Reproduced from Ref. [31] with permission from Elsevier.

Mentions: Bone cells can be only responsive to certain concentration of growth factors, so the controlled release in 3D scaffolds seems to be very important for efficient bone regeneration [37]. Liu et al. [80] fabricated a bone morphogenetic protein (BMP-2)-loaded gelatin–HA composite scaffolds for segmental bone regeneration. The results showed that biomolecule-releasing scaffolds can significantly enhance bone marrow stem cell osteogenic differentiation and repair the segmental bone defect completely in 12 weeks. In addition, the growth factors (BMP) loaded in composite scaffolds could present a sustained release, which could accelerate the bone response process. Other growth factors such as vascular endothelial growth factor, transforming growth factor β and growth/differentiation factor 5 were also loaded in scaffolds for improved tissue engineering applications [81, 82]. Ma and co-workers fabricated a 3D nanofibrous scaffolds with the capability of controlled releasing BMP-7 [83], as shown in Fig. 6. The growth factors were first encapsulated into the polymer microspheres and then immobilized onto nanofibrous scaffolds. These functional scaffolds with controlled BMP-7 releasing ability showed significantly high ectopic bone formation ability compared with the scaffolds by passive adsorption of BMP-7.Figure 6.


Functionalized scaffolds to enhance tissue regeneration.

Guo B, Lei B, Li P, Ma PX - Regen Biomater (2015)

Functionalized PLA nano-fibrous scaffolds incorporating recombinant human bone morphogenetic protein-7 (rhBMP-7) nanospheres. (A, B) rhBMP-7-loaded nanosphere and scaffolds; (C–F) SEM images of nano-fibrous scaffolds before (C and D) and after nanosphere incorporation (E and F). Reproduced from Ref. [31] with permission from Elsevier.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383297&req=5

rbu016-F6: Functionalized PLA nano-fibrous scaffolds incorporating recombinant human bone morphogenetic protein-7 (rhBMP-7) nanospheres. (A, B) rhBMP-7-loaded nanosphere and scaffolds; (C–F) SEM images of nano-fibrous scaffolds before (C and D) and after nanosphere incorporation (E and F). Reproduced from Ref. [31] with permission from Elsevier.
Mentions: Bone cells can be only responsive to certain concentration of growth factors, so the controlled release in 3D scaffolds seems to be very important for efficient bone regeneration [37]. Liu et al. [80] fabricated a bone morphogenetic protein (BMP-2)-loaded gelatin–HA composite scaffolds for segmental bone regeneration. The results showed that biomolecule-releasing scaffolds can significantly enhance bone marrow stem cell osteogenic differentiation and repair the segmental bone defect completely in 12 weeks. In addition, the growth factors (BMP) loaded in composite scaffolds could present a sustained release, which could accelerate the bone response process. Other growth factors such as vascular endothelial growth factor, transforming growth factor β and growth/differentiation factor 5 were also loaded in scaffolds for improved tissue engineering applications [81, 82]. Ma and co-workers fabricated a 3D nanofibrous scaffolds with the capability of controlled releasing BMP-7 [83], as shown in Fig. 6. The growth factors were first encapsulated into the polymer microspheres and then immobilized onto nanofibrous scaffolds. These functional scaffolds with controlled BMP-7 releasing ability showed significantly high ectopic bone formation ability compared with the scaffolds by passive adsorption of BMP-7.Figure 6.

Bottom Line: It not only provides a temporary 3-dimensional support during tissue repair, but also regulates the cell behavior, such as cell adhesion, proliferation and differentiation.Furthermore, the progress on the fabrication of biomimetic nanofibrous scaffolds from conducting polymers and composites of HA and BG via electrospinning, deposition and thermally induced phase separation is discussed.Moreover, bioactive molecules and surface properties of scaffolds are very important during tissue repair.

View Article: PubMed Central - PubMed

Affiliation: Center for Biomedical Engineering and Regenerative Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.

ABSTRACT

Tissue engineering scaffolds play a vital role in regenerative medicine. It not only provides a temporary 3-dimensional support during tissue repair, but also regulates the cell behavior, such as cell adhesion, proliferation and differentiation. In this review, we summarize the development and trends of functional scaffolding biomaterials including electrically conducting hydrogels and nano-composites of hydroxyapatite (HA) and bioactive glasses (BGs) with various biodegradable polymers. Furthermore, the progress on the fabrication of biomimetic nanofibrous scaffolds from conducting polymers and composites of HA and BG via electrospinning, deposition and thermally induced phase separation is discussed. Moreover, bioactive molecules and surface properties of scaffolds are very important during tissue repair. Bioactive molecule-releasing scaffolds and antimicrobial surface coatings for biomedical implants and scaffolds are also reviewed.

No MeSH data available.


Related in: MedlinePlus