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Functionalized scaffolds to enhance tissue regeneration.

Guo B, Lei B, Li P, Ma PX - Regen Biomater (2015)

Bottom Line: It not only provides a temporary 3-dimensional support during tissue repair, but also regulates the cell behavior, such as cell adhesion, proliferation and differentiation.Furthermore, the progress on the fabrication of biomimetic nanofibrous scaffolds from conducting polymers and composites of HA and BG via electrospinning, deposition and thermally induced phase separation is discussed.Moreover, bioactive molecules and surface properties of scaffolds are very important during tissue repair.

View Article: PubMed Central - PubMed

Affiliation: Center for Biomedical Engineering and Regenerative Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.

ABSTRACT

Tissue engineering scaffolds play a vital role in regenerative medicine. It not only provides a temporary 3-dimensional support during tissue repair, but also regulates the cell behavior, such as cell adhesion, proliferation and differentiation. In this review, we summarize the development and trends of functional scaffolding biomaterials including electrically conducting hydrogels and nano-composites of hydroxyapatite (HA) and bioactive glasses (BGs) with various biodegradable polymers. Furthermore, the progress on the fabrication of biomimetic nanofibrous scaffolds from conducting polymers and composites of HA and BG via electrospinning, deposition and thermally induced phase separation is discussed. Moreover, bioactive molecules and surface properties of scaffolds are very important during tissue repair. Bioactive molecule-releasing scaffolds and antimicrobial surface coatings for biomedical implants and scaffolds are also reviewed.

No MeSH data available.


Related in: MedlinePlus

Biomimetic gelatin and gelatin–apatite nanofibrous scaffolds fabricated by TIPS and biomineralization methods. (A–C) Morphology and microstructure of nanofibrous scaffolds; (D–F) scaffolds after biomineralization for 7 days (D and E) and 21 days (F). Reproduced from Ref. [31] with permission from Elsevier.
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rbu016-F5: Biomimetic gelatin and gelatin–apatite nanofibrous scaffolds fabricated by TIPS and biomineralization methods. (A–C) Morphology and microstructure of nanofibrous scaffolds; (D–F) scaffolds after biomineralization for 7 days (D and E) and 21 days (F). Reproduced from Ref. [31] with permission from Elsevier.

Mentions: Electrospun-derived nanofibrous scaffolds showed limited pore size ranging from several micrometers to 100 µm which is unfavorable for cell infiltration and growth. To address this problem, thermal induced phase separation (TIPS) technique was developed to fabricate macroporous nanofibrous scaffolds. Ma and co-workers have done much pioneering work about TIPS nanofibrous scaffolds for bone tissue engineering [73]. For example, Ma et al. fabricated the gelatin and gelatin–apatite composite nanofibrous scaffolds by TIPS method and apatite layer coating after biomineralization in simulated body fluid (SBF), as show in Fig. 5 [74]. The coated gelatin composite nanofibrous scaffolds showed significantly high mechanical strength and enhanced osteogenic genes expressions. The improved biocompatibility of nanofibrous composite scaffolds for bone tissue regeneration could be attributed to their biomimetic and biomineralized bone extracellular environment.Figure 5.


Functionalized scaffolds to enhance tissue regeneration.

Guo B, Lei B, Li P, Ma PX - Regen Biomater (2015)

Biomimetic gelatin and gelatin–apatite nanofibrous scaffolds fabricated by TIPS and biomineralization methods. (A–C) Morphology and microstructure of nanofibrous scaffolds; (D–F) scaffolds after biomineralization for 7 days (D and E) and 21 days (F). Reproduced from Ref. [31] with permission from Elsevier.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383297&req=5

rbu016-F5: Biomimetic gelatin and gelatin–apatite nanofibrous scaffolds fabricated by TIPS and biomineralization methods. (A–C) Morphology and microstructure of nanofibrous scaffolds; (D–F) scaffolds after biomineralization for 7 days (D and E) and 21 days (F). Reproduced from Ref. [31] with permission from Elsevier.
Mentions: Electrospun-derived nanofibrous scaffolds showed limited pore size ranging from several micrometers to 100 µm which is unfavorable for cell infiltration and growth. To address this problem, thermal induced phase separation (TIPS) technique was developed to fabricate macroporous nanofibrous scaffolds. Ma and co-workers have done much pioneering work about TIPS nanofibrous scaffolds for bone tissue engineering [73]. For example, Ma et al. fabricated the gelatin and gelatin–apatite composite nanofibrous scaffolds by TIPS method and apatite layer coating after biomineralization in simulated body fluid (SBF), as show in Fig. 5 [74]. The coated gelatin composite nanofibrous scaffolds showed significantly high mechanical strength and enhanced osteogenic genes expressions. The improved biocompatibility of nanofibrous composite scaffolds for bone tissue regeneration could be attributed to their biomimetic and biomineralized bone extracellular environment.Figure 5.

Bottom Line: It not only provides a temporary 3-dimensional support during tissue repair, but also regulates the cell behavior, such as cell adhesion, proliferation and differentiation.Furthermore, the progress on the fabrication of biomimetic nanofibrous scaffolds from conducting polymers and composites of HA and BG via electrospinning, deposition and thermally induced phase separation is discussed.Moreover, bioactive molecules and surface properties of scaffolds are very important during tissue repair.

View Article: PubMed Central - PubMed

Affiliation: Center for Biomedical Engineering and Regenerative Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.

ABSTRACT

Tissue engineering scaffolds play a vital role in regenerative medicine. It not only provides a temporary 3-dimensional support during tissue repair, but also regulates the cell behavior, such as cell adhesion, proliferation and differentiation. In this review, we summarize the development and trends of functional scaffolding biomaterials including electrically conducting hydrogels and nano-composites of hydroxyapatite (HA) and bioactive glasses (BGs) with various biodegradable polymers. Furthermore, the progress on the fabrication of biomimetic nanofibrous scaffolds from conducting polymers and composites of HA and BG via electrospinning, deposition and thermally induced phase separation is discussed. Moreover, bioactive molecules and surface properties of scaffolds are very important during tissue repair. Bioactive molecule-releasing scaffolds and antimicrobial surface coatings for biomedical implants and scaffolds are also reviewed.

No MeSH data available.


Related in: MedlinePlus