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The construction of common and specific significance subnetworks of Alzheimer's disease from multiple brain regions.

Kong W, Mou X, Zhang N, Zeng W, Li S, Yang Y - Biomed Res Int (2015)

Bottom Line: In this paper, commonly and specifically significant subnetworks were identified from six AD brain regions.The identified common subnetworks showed that inflammation of the brain nerves is one of the critical factors of AD and calcium imbalance may be a link among several causative factors in AD pathogenesis.In addition, the extracted specific subnetworks for each brain region revealed many biologically functional mechanisms to understand AD pathogenesis.

View Article: PubMed Central - PubMed

Affiliation: Information Engineering College, Shanghai Maritime University, Shanghai 201306, China.

ABSTRACT
Alzheimer's disease (AD) is a progressively and fatally neurodegenerative disorder and leads to irreversibly cognitive and memorial damage in different brain regions. The identification and analysis of the dysregulated pathways and subnetworks among affected brain regions will provide deep insights for the pathogenetic mechanism of AD. In this paper, commonly and specifically significant subnetworks were identified from six AD brain regions. Protein-protein interaction (PPI) data were integrated to add molecular biological information to construct the functional modules of six AD brain regions by Heinz algorithm. Then, the simulated annealing algorithm based on edge weight is applied to predicting and optimizing the maximal scoring networks for common and specific genes, respectively, which can remove the weak interactions and add the prediction of strong interactions to increase the accuracy of the networks. The identified common subnetworks showed that inflammation of the brain nerves is one of the critical factors of AD and calcium imbalance may be a link among several causative factors in AD pathogenesis. In addition, the extracted specific subnetworks for each brain region revealed many biologically functional mechanisms to understand AD pathogenesis.

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Related in: MedlinePlus

Functional subnetwork of the calcium ion mechanism constructed by common genes.
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fig3: Functional subnetwork of the calcium ion mechanism constructed by common genes.

Mentions: In addition to inflammatory response, another important subnetwork we found from the common genes was calcium ion metabolism subnetwork. Figure 3 showed the subnetwork of the calcium ion mechanism with the extracted common genes, and the KEGG pathway analysis of this subnetwork was provided in Table 2.


The construction of common and specific significance subnetworks of Alzheimer's disease from multiple brain regions.

Kong W, Mou X, Zhang N, Zeng W, Li S, Yang Y - Biomed Res Int (2015)

Functional subnetwork of the calcium ion mechanism constructed by common genes.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383160&req=5

fig3: Functional subnetwork of the calcium ion mechanism constructed by common genes.
Mentions: In addition to inflammatory response, another important subnetwork we found from the common genes was calcium ion metabolism subnetwork. Figure 3 showed the subnetwork of the calcium ion mechanism with the extracted common genes, and the KEGG pathway analysis of this subnetwork was provided in Table 2.

Bottom Line: In this paper, commonly and specifically significant subnetworks were identified from six AD brain regions.The identified common subnetworks showed that inflammation of the brain nerves is one of the critical factors of AD and calcium imbalance may be a link among several causative factors in AD pathogenesis.In addition, the extracted specific subnetworks for each brain region revealed many biologically functional mechanisms to understand AD pathogenesis.

View Article: PubMed Central - PubMed

Affiliation: Information Engineering College, Shanghai Maritime University, Shanghai 201306, China.

ABSTRACT
Alzheimer's disease (AD) is a progressively and fatally neurodegenerative disorder and leads to irreversibly cognitive and memorial damage in different brain regions. The identification and analysis of the dysregulated pathways and subnetworks among affected brain regions will provide deep insights for the pathogenetic mechanism of AD. In this paper, commonly and specifically significant subnetworks were identified from six AD brain regions. Protein-protein interaction (PPI) data were integrated to add molecular biological information to construct the functional modules of six AD brain regions by Heinz algorithm. Then, the simulated annealing algorithm based on edge weight is applied to predicting and optimizing the maximal scoring networks for common and specific genes, respectively, which can remove the weak interactions and add the prediction of strong interactions to increase the accuracy of the networks. The identified common subnetworks showed that inflammation of the brain nerves is one of the critical factors of AD and calcium imbalance may be a link among several causative factors in AD pathogenesis. In addition, the extracted specific subnetworks for each brain region revealed many biologically functional mechanisms to understand AD pathogenesis.

Show MeSH
Related in: MedlinePlus