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Analysis of chromosome 17 miRNAs and their importance in medulloblastomas.

López-Ochoa S, Ramírez-García M, Castro-Sierra E, Arenas-Huertero F - Biomed Res Int (2015)

Bottom Line: Some of them are miRNA-5047, miRNA-1253, miRNA-2909, and miRNA-634.Everyone can significantly affect the development, growth, and cell invasion of MB, and they have not been explored in this tumor.In this review, we propose some miRNAs that can affect some genes in MB, and hence the importance of its study.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Research in Experimental Pathology, Hospital Infantil de Mexico Federico Gomez, Avenida Dr. Márquez 162, Colonia Doctores 06720, México, DF, Mexico.

ABSTRACT
MicroRNAs (miRNAs) are small sequences of nucleotides that regulate posttranscriptionally gene expression. In recent years they have been recognized as very important general regulators of proliferation, differentiation, adhesion, cell death, and others. In some cases, the characteristic presence of miRNAs reflects some of the cellular pathways that may be altered. Particularly medulloblastomas (MB) represent entities that undergo almost characteristic alterations of chromosome 17: from loss of discrete fragments and isochromosomes formation to complete loss of one of them. An analysis of the major loci on this chromosome revealed that it contains at least 19 genes encoding miRNAs which may regulate the development and differentiation of the brain and cerebellum. miRNAs are regulators of real complex networks; they can regulate from 100 to over 300 messengers of various proteins. In this review some miRNAs are considered to be important in MB studies. Some of them are miRNA-5047, miRNA-1253, miRNA-2909, and miRNA-634. Everyone can significantly affect the development, growth, and cell invasion of MB, and they have not been explored in this tumor. In this review, we propose some miRNAs that can affect some genes in MB, and hence the importance of its study.

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Related in: MedlinePlus

Pathway proposed in which overexpression of miRNA-634 can affect HDAC2 and open chromatin in MB.
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fig5: Pathway proposed in which overexpression of miRNA-634 can affect HDAC2 and open chromatin in MB.

Mentions: Among the important target sequences of this miRNA that are implicated in MB, one of the most interesting gene is the mRNA of histone deacetylase 2 HDAC2. This gene encodes an enzyme that deacetylates histone lysines. This increased expression of HDAC2 might cause an increase of positively charged deacetylated lysines that may be related to transcriptionally closed chromatin, repressing some of the genes under the control of HDAC2 in MB (Figure 5). If levels of miRNA-634 increase, it reduces HDAC2 and it turns on open chromatin and transcription of genes of proliferation among others [54].


Analysis of chromosome 17 miRNAs and their importance in medulloblastomas.

López-Ochoa S, Ramírez-García M, Castro-Sierra E, Arenas-Huertero F - Biomed Res Int (2015)

Pathway proposed in which overexpression of miRNA-634 can affect HDAC2 and open chromatin in MB.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383152&req=5

fig5: Pathway proposed in which overexpression of miRNA-634 can affect HDAC2 and open chromatin in MB.
Mentions: Among the important target sequences of this miRNA that are implicated in MB, one of the most interesting gene is the mRNA of histone deacetylase 2 HDAC2. This gene encodes an enzyme that deacetylates histone lysines. This increased expression of HDAC2 might cause an increase of positively charged deacetylated lysines that may be related to transcriptionally closed chromatin, repressing some of the genes under the control of HDAC2 in MB (Figure 5). If levels of miRNA-634 increase, it reduces HDAC2 and it turns on open chromatin and transcription of genes of proliferation among others [54].

Bottom Line: Some of them are miRNA-5047, miRNA-1253, miRNA-2909, and miRNA-634.Everyone can significantly affect the development, growth, and cell invasion of MB, and they have not been explored in this tumor.In this review, we propose some miRNAs that can affect some genes in MB, and hence the importance of its study.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Research in Experimental Pathology, Hospital Infantil de Mexico Federico Gomez, Avenida Dr. Márquez 162, Colonia Doctores 06720, México, DF, Mexico.

ABSTRACT
MicroRNAs (miRNAs) are small sequences of nucleotides that regulate posttranscriptionally gene expression. In recent years they have been recognized as very important general regulators of proliferation, differentiation, adhesion, cell death, and others. In some cases, the characteristic presence of miRNAs reflects some of the cellular pathways that may be altered. Particularly medulloblastomas (MB) represent entities that undergo almost characteristic alterations of chromosome 17: from loss of discrete fragments and isochromosomes formation to complete loss of one of them. An analysis of the major loci on this chromosome revealed that it contains at least 19 genes encoding miRNAs which may regulate the development and differentiation of the brain and cerebellum. miRNAs are regulators of real complex networks; they can regulate from 100 to over 300 messengers of various proteins. In this review some miRNAs are considered to be important in MB studies. Some of them are miRNA-5047, miRNA-1253, miRNA-2909, and miRNA-634. Everyone can significantly affect the development, growth, and cell invasion of MB, and they have not been explored in this tumor. In this review, we propose some miRNAs that can affect some genes in MB, and hence the importance of its study.

Show MeSH
Related in: MedlinePlus