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Analysis of chromosome 17 miRNAs and their importance in medulloblastomas.

López-Ochoa S, Ramírez-García M, Castro-Sierra E, Arenas-Huertero F - Biomed Res Int (2015)

Bottom Line: Some of them are miRNA-5047, miRNA-1253, miRNA-2909, and miRNA-634.Everyone can significantly affect the development, growth, and cell invasion of MB, and they have not been explored in this tumor.In this review, we propose some miRNAs that can affect some genes in MB, and hence the importance of its study.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Research in Experimental Pathology, Hospital Infantil de Mexico Federico Gomez, Avenida Dr. Márquez 162, Colonia Doctores 06720, México, DF, Mexico.

ABSTRACT
MicroRNAs (miRNAs) are small sequences of nucleotides that regulate posttranscriptionally gene expression. In recent years they have been recognized as very important general regulators of proliferation, differentiation, adhesion, cell death, and others. In some cases, the characteristic presence of miRNAs reflects some of the cellular pathways that may be altered. Particularly medulloblastomas (MB) represent entities that undergo almost characteristic alterations of chromosome 17: from loss of discrete fragments and isochromosomes formation to complete loss of one of them. An analysis of the major loci on this chromosome revealed that it contains at least 19 genes encoding miRNAs which may regulate the development and differentiation of the brain and cerebellum. miRNAs are regulators of real complex networks; they can regulate from 100 to over 300 messengers of various proteins. In this review some miRNAs are considered to be important in MB studies. Some of them are miRNA-5047, miRNA-1253, miRNA-2909, and miRNA-634. Everyone can significantly affect the development, growth, and cell invasion of MB, and they have not been explored in this tumor. In this review, we propose some miRNAs that can affect some genes in MB, and hence the importance of its study.

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Related in: MedlinePlus

Pathway proposed in which miRNA-1253 and miRNA-5047 can deregulate some functions due to their overexpression and some cellular effects on proliferation and apoptosis in MB.
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fig3: Pathway proposed in which miRNA-1253 and miRNA-5047 can deregulate some functions due to their overexpression and some cellular effects on proliferation and apoptosis in MB.

Mentions: These results clearly reveal what the responses in vitro do not appear to correspond to the in vivo responses, so it is always necessary to validate and compare the results of the two assays. What is clear is that miRNA-1253 may have an important role in MB cells, negatively regulating an antagonist of the positive effects of the differentiation factors BMP2 and BMP4, thus causing a gain of function such as MB cell proliferation (Figure 3).


Analysis of chromosome 17 miRNAs and their importance in medulloblastomas.

López-Ochoa S, Ramírez-García M, Castro-Sierra E, Arenas-Huertero F - Biomed Res Int (2015)

Pathway proposed in which miRNA-1253 and miRNA-5047 can deregulate some functions due to their overexpression and some cellular effects on proliferation and apoptosis in MB.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383152&req=5

fig3: Pathway proposed in which miRNA-1253 and miRNA-5047 can deregulate some functions due to their overexpression and some cellular effects on proliferation and apoptosis in MB.
Mentions: These results clearly reveal what the responses in vitro do not appear to correspond to the in vivo responses, so it is always necessary to validate and compare the results of the two assays. What is clear is that miRNA-1253 may have an important role in MB cells, negatively regulating an antagonist of the positive effects of the differentiation factors BMP2 and BMP4, thus causing a gain of function such as MB cell proliferation (Figure 3).

Bottom Line: Some of them are miRNA-5047, miRNA-1253, miRNA-2909, and miRNA-634.Everyone can significantly affect the development, growth, and cell invasion of MB, and they have not been explored in this tumor.In this review, we propose some miRNAs that can affect some genes in MB, and hence the importance of its study.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Research in Experimental Pathology, Hospital Infantil de Mexico Federico Gomez, Avenida Dr. Márquez 162, Colonia Doctores 06720, México, DF, Mexico.

ABSTRACT
MicroRNAs (miRNAs) are small sequences of nucleotides that regulate posttranscriptionally gene expression. In recent years they have been recognized as very important general regulators of proliferation, differentiation, adhesion, cell death, and others. In some cases, the characteristic presence of miRNAs reflects some of the cellular pathways that may be altered. Particularly medulloblastomas (MB) represent entities that undergo almost characteristic alterations of chromosome 17: from loss of discrete fragments and isochromosomes formation to complete loss of one of them. An analysis of the major loci on this chromosome revealed that it contains at least 19 genes encoding miRNAs which may regulate the development and differentiation of the brain and cerebellum. miRNAs are regulators of real complex networks; they can regulate from 100 to over 300 messengers of various proteins. In this review some miRNAs are considered to be important in MB studies. Some of them are miRNA-5047, miRNA-1253, miRNA-2909, and miRNA-634. Everyone can significantly affect the development, growth, and cell invasion of MB, and they have not been explored in this tumor. In this review, we propose some miRNAs that can affect some genes in MB, and hence the importance of its study.

Show MeSH
Related in: MedlinePlus