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Comparative analysis of efficacy of lignocaine 1.5 mg/kg and two different doses of dexmedetomidine (0.5 μg/kg and 1 μg/kg) in attenuating the hemodynamic pressure response to laryngoscopy and intubation.

Gulabani M, Gurha P, Dass P, Kulshreshtha N - Anesth Essays Res (2015 Jan-Apr)

Bottom Line: Dexmedetomidine has sympatholytic effects.Dexmedetomidine 1µg/kg was more effective than 0.5µg/kg and lignocaine 1.5mg/kg in attenuating the pressor response.We conclude that dexmedetomidine 1μg/kg adequately attenuates the hemodynamic response to laryngoscopy and endotracheal intubation when compared with dexmedetomidine 0.5μg/kg and lignocaine 1.5mg/kg.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Critical Care, Dr. Ram Manohar Lohia Hospital, New Delhi, India.

ABSTRACT

Context: Laryngoscopy and intubation cause an intense reflex increase in heart rate, blood pressure, due to an increased sympathoadrenal pressor response. Lignoocaine has shown blunting of pressor response to intubation. Dexmedetomidine has sympatholytic effects.

Aims: To the best of our knowledge there is no study comparing the efficacy of lignocaine with two different doses of dexmedetomidine for attenuating the pressor response. With this idea, we planned to conduct the present study.

Materials and methods: After approval by the Hospital Ethics committee, 90 consenting adults aged 18-65 years of age of either sex of non-hypertensive ASA Grade I or II were randomly allocated into three groups. Group D1- IV Dexmedetomidine 0.5μg/kg over 10 minutes Group D2- IV Dexmedetomidine 1μg/kg over 10 minutes Group X- IV Lignocaine 1.5mg/kg in 10 ml normal saline.

Statistical analysis used: ANOVA and Student's t test used for analysis.

Results: Dexmedetomidine 1µg/kg was more effective than 0.5µg/kg and lignocaine 1.5mg/kg in attenuating the pressor response.

Conclusions: We conclude that dexmedetomidine 1μg/kg adequately attenuates the hemodynamic response to laryngoscopy and endotracheal intubation when compared with dexmedetomidine 0.5μg/kg and lignocaine 1.5mg/kg.

No MeSH data available.


Comparison of heart rate in the dexmedetomidine 0.5 µg/kg group at different time intervals
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Figure 4: Comparison of heart rate in the dexmedetomidine 0.5 µg/kg group at different time intervals

Mentions: Graph 2 depicts the variation in the HR at different instances of time with the use of dexmedetomidine 0.5 μg/kg. A general decline in the HR when compared with the baseline was observed [Table 4].


Comparative analysis of efficacy of lignocaine 1.5 mg/kg and two different doses of dexmedetomidine (0.5 μg/kg and 1 μg/kg) in attenuating the hemodynamic pressure response to laryngoscopy and intubation.

Gulabani M, Gurha P, Dass P, Kulshreshtha N - Anesth Essays Res (2015 Jan-Apr)

Comparison of heart rate in the dexmedetomidine 0.5 µg/kg group at different time intervals
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4383101&req=5

Figure 4: Comparison of heart rate in the dexmedetomidine 0.5 µg/kg group at different time intervals
Mentions: Graph 2 depicts the variation in the HR at different instances of time with the use of dexmedetomidine 0.5 μg/kg. A general decline in the HR when compared with the baseline was observed [Table 4].

Bottom Line: Dexmedetomidine has sympatholytic effects.Dexmedetomidine 1µg/kg was more effective than 0.5µg/kg and lignocaine 1.5mg/kg in attenuating the pressor response.We conclude that dexmedetomidine 1μg/kg adequately attenuates the hemodynamic response to laryngoscopy and endotracheal intubation when compared with dexmedetomidine 0.5μg/kg and lignocaine 1.5mg/kg.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Critical Care, Dr. Ram Manohar Lohia Hospital, New Delhi, India.

ABSTRACT

Context: Laryngoscopy and intubation cause an intense reflex increase in heart rate, blood pressure, due to an increased sympathoadrenal pressor response. Lignoocaine has shown blunting of pressor response to intubation. Dexmedetomidine has sympatholytic effects.

Aims: To the best of our knowledge there is no study comparing the efficacy of lignocaine with two different doses of dexmedetomidine for attenuating the pressor response. With this idea, we planned to conduct the present study.

Materials and methods: After approval by the Hospital Ethics committee, 90 consenting adults aged 18-65 years of age of either sex of non-hypertensive ASA Grade I or II were randomly allocated into three groups. Group D1- IV Dexmedetomidine 0.5μg/kg over 10 minutes Group D2- IV Dexmedetomidine 1μg/kg over 10 minutes Group X- IV Lignocaine 1.5mg/kg in 10 ml normal saline.

Statistical analysis used: ANOVA and Student's t test used for analysis.

Results: Dexmedetomidine 1µg/kg was more effective than 0.5µg/kg and lignocaine 1.5mg/kg in attenuating the pressor response.

Conclusions: We conclude that dexmedetomidine 1μg/kg adequately attenuates the hemodynamic response to laryngoscopy and endotracheal intubation when compared with dexmedetomidine 0.5μg/kg and lignocaine 1.5mg/kg.

No MeSH data available.