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Hemoglobin D-Punjab: origin, distribution and laboratory diagnosis.

Torres Lde S, Okumura JV, Silva DG, Bonini-Domingos CR - Rev Bras Hematol Hemoter (2015)

Bottom Line: Although hemoglobin D-Punjab is a common variant globally with clinical importance especially in cases of double heterozygosis, hemoglobin S/D-Punjab is still understudied.Thus, this paper summarizes information about the origin, geographic distribution, characterization and occurrence of hemoglobin D-Punjab haplotypes to try to improve our knowledge of this variant.Moreover, a list of the main techniques used in its identification is provided emphasizing the importance of complementary molecular analysis for accurate diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Universidade Estadual Paulista (UNESP), São José do Rio Preto, SP, Brazil. Electronic address: lidiane.unesp@gmail.com.

No MeSH data available.


Related in: MedlinePlus

Schematic representation of relative mobilities of different hemoglobins using the isoelectric focusing method. Hb D-Punjab is shown in the figure with isoelectric point (pI) between 7.1 and 7.2.
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fig0015: Schematic representation of relative mobilities of different hemoglobins using the isoelectric focusing method. Hb D-Punjab is shown in the figure with isoelectric point (pI) between 7.1 and 7.2.

Mentions: It is also possible to separate hemoglobins according to their isoelectric point (pI) by isoelectric focusing (IEF).39 In the case of Hb D-Punjab, its pI is near to pH 7.1, a position similar to other hemoglobin variants such as Hb Korle-Bu (Figure 3). Although it has great resolution, this technique requires specific kits and is more expensive than conventional electrophoresis.


Hemoglobin D-Punjab: origin, distribution and laboratory diagnosis.

Torres Lde S, Okumura JV, Silva DG, Bonini-Domingos CR - Rev Bras Hematol Hemoter (2015)

Schematic representation of relative mobilities of different hemoglobins using the isoelectric focusing method. Hb D-Punjab is shown in the figure with isoelectric point (pI) between 7.1 and 7.2.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4382585&req=5

fig0015: Schematic representation of relative mobilities of different hemoglobins using the isoelectric focusing method. Hb D-Punjab is shown in the figure with isoelectric point (pI) between 7.1 and 7.2.
Mentions: It is also possible to separate hemoglobins according to their isoelectric point (pI) by isoelectric focusing (IEF).39 In the case of Hb D-Punjab, its pI is near to pH 7.1, a position similar to other hemoglobin variants such as Hb Korle-Bu (Figure 3). Although it has great resolution, this technique requires specific kits and is more expensive than conventional electrophoresis.

Bottom Line: Although hemoglobin D-Punjab is a common variant globally with clinical importance especially in cases of double heterozygosis, hemoglobin S/D-Punjab is still understudied.Thus, this paper summarizes information about the origin, geographic distribution, characterization and occurrence of hemoglobin D-Punjab haplotypes to try to improve our knowledge of this variant.Moreover, a list of the main techniques used in its identification is provided emphasizing the importance of complementary molecular analysis for accurate diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Universidade Estadual Paulista (UNESP), São José do Rio Preto, SP, Brazil. Electronic address: lidiane.unesp@gmail.com.

No MeSH data available.


Related in: MedlinePlus