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Ebola: a holistic approach is required to achieve effective management and control.

Roca A, Afolabi MO, Saidu Y, Kampmann B - J. Allergy Clin. Immunol. (2015)

Bottom Line: The scale of the epidemic has accelerated research efforts for diagnostics, treatment, and prevention galvanized through increased availability of funding.However, there is a long way to go.In this review we summarize the current knowledge, examine the sociocultural context in West Africa, and outline priority areas for future research.

View Article: PubMed Central - PubMed

Affiliation: The Medical Research Unit (MRC), Fajara, The Gambia.

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Viral assembly model of Ebola virus. Viral mRNA transcribed from genomic negative-sense RNA is released into the cytoplasm, where VPs are translated. Nucleoprotein, together with VP35, VP40, VP30, and VP24, forms small inclusions (A), which become larger near the nucleus (B). At the edge of the inclusion bodies, the nucleocapsid (NC) is formed. VP40 associates with the NC, contributing to its transport to the plasma membrane (C1). Alternatively, nucleocapside initially associates with a few VP40 molecules and then moves to the plasma membrane, where it is enveloped with membrane-associated VP40 (C2). Synthesized glycoprotein (GP) is independently transported to the plasma membrane (D). The viral components then assemble, and the progeny virions bud (E). ER, Endoplasmic reticulum. Reprinted with permission from Nanbo et al.21
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fig2: Viral assembly model of Ebola virus. Viral mRNA transcribed from genomic negative-sense RNA is released into the cytoplasm, where VPs are translated. Nucleoprotein, together with VP35, VP40, VP30, and VP24, forms small inclusions (A), which become larger near the nucleus (B). At the edge of the inclusion bodies, the nucleocapsid (NC) is formed. VP40 associates with the NC, contributing to its transport to the plasma membrane (C1). Alternatively, nucleocapside initially associates with a few VP40 molecules and then moves to the plasma membrane, where it is enveloped with membrane-associated VP40 (C2). Synthesized glycoprotein (GP) is independently transported to the plasma membrane (D). The viral components then assemble, and the progeny virions bud (E). ER, Endoplasmic reticulum. Reprinted with permission from Nanbo et al.21

Mentions: The process of replication and transcription of the viral genome is activated by the VPs that contain the nucleoprotein.24,25 When compared with Marburg virus, the N-terminal region of nucleoprotein defines the inner diameter of the EV nucleocapside, whereas the RNA genome defines its length.26 The details of viral assembly are summarized in Fig 2.


Ebola: a holistic approach is required to achieve effective management and control.

Roca A, Afolabi MO, Saidu Y, Kampmann B - J. Allergy Clin. Immunol. (2015)

Viral assembly model of Ebola virus. Viral mRNA transcribed from genomic negative-sense RNA is released into the cytoplasm, where VPs are translated. Nucleoprotein, together with VP35, VP40, VP30, and VP24, forms small inclusions (A), which become larger near the nucleus (B). At the edge of the inclusion bodies, the nucleocapsid (NC) is formed. VP40 associates with the NC, contributing to its transport to the plasma membrane (C1). Alternatively, nucleocapside initially associates with a few VP40 molecules and then moves to the plasma membrane, where it is enveloped with membrane-associated VP40 (C2). Synthesized glycoprotein (GP) is independently transported to the plasma membrane (D). The viral components then assemble, and the progeny virions bud (E). ER, Endoplasmic reticulum. Reprinted with permission from Nanbo et al.21
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4382328&req=5

fig2: Viral assembly model of Ebola virus. Viral mRNA transcribed from genomic negative-sense RNA is released into the cytoplasm, where VPs are translated. Nucleoprotein, together with VP35, VP40, VP30, and VP24, forms small inclusions (A), which become larger near the nucleus (B). At the edge of the inclusion bodies, the nucleocapsid (NC) is formed. VP40 associates with the NC, contributing to its transport to the plasma membrane (C1). Alternatively, nucleocapside initially associates with a few VP40 molecules and then moves to the plasma membrane, where it is enveloped with membrane-associated VP40 (C2). Synthesized glycoprotein (GP) is independently transported to the plasma membrane (D). The viral components then assemble, and the progeny virions bud (E). ER, Endoplasmic reticulum. Reprinted with permission from Nanbo et al.21
Mentions: The process of replication and transcription of the viral genome is activated by the VPs that contain the nucleoprotein.24,25 When compared with Marburg virus, the N-terminal region of nucleoprotein defines the inner diameter of the EV nucleocapside, whereas the RNA genome defines its length.26 The details of viral assembly are summarized in Fig 2.

Bottom Line: The scale of the epidemic has accelerated research efforts for diagnostics, treatment, and prevention galvanized through increased availability of funding.However, there is a long way to go.In this review we summarize the current knowledge, examine the sociocultural context in West Africa, and outline priority areas for future research.

View Article: PubMed Central - PubMed

Affiliation: The Medical Research Unit (MRC), Fajara, The Gambia.

Show MeSH
Related in: MedlinePlus