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Clinicopathological significance of dual-specificity protein phosphatase 4 expression in invasive ductal carcinoma of the breast.

Kim H, Jang SM, Ahn H, Sim J, Yi K, Chung Y, Han H, Rehman A, Chung MS, Jang K, Paik SS - J Breast Cancer (2015)

Bottom Line: The mean DUSP4 expression score was significantly higher in malignant tumors than in benign lesions (p=0.019).Interestingly, Kaplan-Meier survival curves revealed that DUSP4 expression had a significant effect on both overall patient survival (p=0.034, log-rank test) and disease-free survival (p=0.045, log-rank test).In early T-stage breast cancer, DUSP4 expression was associated with a worse prognosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Hanyang University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: Dual-specificity protein phosphatase 4 (DUSP4), also known as mitogen-activated protein kinase phosphatase (MKP) 2 is a member of the inducible nuclear MKP group. The role of DUSP4 in cancer development and progression appears to vary with the type of malignancy. The purpose of this study was to investigate DUSP4 expression in a case series of invasive ductal carcinoma of the breast.

Methods: We constructed tissue microarrays consisting of 16, 14, 47, and 266 cases of normal breast tissue, usual ductal hyperplasia, ductal carcinoma in situ, and invasive ductal carcinoma, respectively. DUSP4 expression was investigated by immunohistochemistry.

Results: Cytoplasmic DUSP4 expression was observed. DUSP4 was more frequently expressed in malignant than in benign cases (p=0.024). The mean DUSP4 expression score was significantly higher in malignant tumors than in benign lesions (p=0.019). DUSP4 expression was significantly correlated with a larger tumor size (>2 cm, p=0.015). There was no significant correlation between overall survival or disease-free survival and DUSP4 expression in all 266 patients. We evaluated the impact of DUSP4 expression on the survival of 120 patients with T1-stage tumors. Interestingly, Kaplan-Meier survival curves revealed that DUSP4 expression had a significant effect on both overall patient survival (p=0.034, log-rank test) and disease-free survival (p=0.045, log-rank test). In early T-stage breast cancer, DUSP4 expression was associated with a worse prognosis.

Conclusion: DUSP4 is frequently upregulated in breast malignancy, and may play an important role in cancer development and progression. In addition, it may be a marker of adverse prognosis, especially in patients with early T1-stage cancer.

No MeSH data available.


Related in: MedlinePlus

Cumulative overall and disease-free survival curves according to dual-specificity protein phosphatase 4 (DUSP4) expression. There was no significant difference of overall and disease-free survival in all 266 patients with invasive ductal carcinoma (A, B). However, there was significant difference of overall and disease-free survival in 120 patients with the T1-stage tumor (C, D) (Kaplan-Meier method with log-rank test).
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Figure 3: Cumulative overall and disease-free survival curves according to dual-specificity protein phosphatase 4 (DUSP4) expression. There was no significant difference of overall and disease-free survival in all 266 patients with invasive ductal carcinoma (A, B). However, there was significant difference of overall and disease-free survival in 120 patients with the T1-stage tumor (C, D) (Kaplan-Meier method with log-rank test).

Mentions: The impact of DUSP4 expression on survival in 266 patients with invasive ductal carcinoma was evaluated. We observed that AJCC stage, lymphatic invasion, perinodal tumor extension, ER/PR status, and triple negativity showed a significant effect on overall and disease-free survival in univariable and/or multivariable analyses (Table 3). However, there was no significant correlation between overall survival or disease-free survival and DUSP4 expression (p=0.924 and p=0.246, respectively; log-rank test) according to the Kaplan-Meier survival curves for all 266 patients with invasive ductal carcinoma (Figure 3A, B). We evaluated the impact of DUSP4 expression on survival in 120 patients with T1-stage tumors (Table 4). We found that DUSP4 expression had a significant effect on overall and disease-free survival in multivariable analysis. Kaplan-Meier survival curves revealed a significant effect of DUSP4 expression on overall survival (p=0.034, log-rank test) and disease-free survival (p=0.045, log-rank test) in early T-stage breast cancer (Figure 3C, D).


Clinicopathological significance of dual-specificity protein phosphatase 4 expression in invasive ductal carcinoma of the breast.

Kim H, Jang SM, Ahn H, Sim J, Yi K, Chung Y, Han H, Rehman A, Chung MS, Jang K, Paik SS - J Breast Cancer (2015)

Cumulative overall and disease-free survival curves according to dual-specificity protein phosphatase 4 (DUSP4) expression. There was no significant difference of overall and disease-free survival in all 266 patients with invasive ductal carcinoma (A, B). However, there was significant difference of overall and disease-free survival in 120 patients with the T1-stage tumor (C, D) (Kaplan-Meier method with log-rank test).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4381116&req=5

Figure 3: Cumulative overall and disease-free survival curves according to dual-specificity protein phosphatase 4 (DUSP4) expression. There was no significant difference of overall and disease-free survival in all 266 patients with invasive ductal carcinoma (A, B). However, there was significant difference of overall and disease-free survival in 120 patients with the T1-stage tumor (C, D) (Kaplan-Meier method with log-rank test).
Mentions: The impact of DUSP4 expression on survival in 266 patients with invasive ductal carcinoma was evaluated. We observed that AJCC stage, lymphatic invasion, perinodal tumor extension, ER/PR status, and triple negativity showed a significant effect on overall and disease-free survival in univariable and/or multivariable analyses (Table 3). However, there was no significant correlation between overall survival or disease-free survival and DUSP4 expression (p=0.924 and p=0.246, respectively; log-rank test) according to the Kaplan-Meier survival curves for all 266 patients with invasive ductal carcinoma (Figure 3A, B). We evaluated the impact of DUSP4 expression on survival in 120 patients with T1-stage tumors (Table 4). We found that DUSP4 expression had a significant effect on overall and disease-free survival in multivariable analysis. Kaplan-Meier survival curves revealed a significant effect of DUSP4 expression on overall survival (p=0.034, log-rank test) and disease-free survival (p=0.045, log-rank test) in early T-stage breast cancer (Figure 3C, D).

Bottom Line: The mean DUSP4 expression score was significantly higher in malignant tumors than in benign lesions (p=0.019).Interestingly, Kaplan-Meier survival curves revealed that DUSP4 expression had a significant effect on both overall patient survival (p=0.034, log-rank test) and disease-free survival (p=0.045, log-rank test).In early T-stage breast cancer, DUSP4 expression was associated with a worse prognosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Hanyang University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: Dual-specificity protein phosphatase 4 (DUSP4), also known as mitogen-activated protein kinase phosphatase (MKP) 2 is a member of the inducible nuclear MKP group. The role of DUSP4 in cancer development and progression appears to vary with the type of malignancy. The purpose of this study was to investigate DUSP4 expression in a case series of invasive ductal carcinoma of the breast.

Methods: We constructed tissue microarrays consisting of 16, 14, 47, and 266 cases of normal breast tissue, usual ductal hyperplasia, ductal carcinoma in situ, and invasive ductal carcinoma, respectively. DUSP4 expression was investigated by immunohistochemistry.

Results: Cytoplasmic DUSP4 expression was observed. DUSP4 was more frequently expressed in malignant than in benign cases (p=0.024). The mean DUSP4 expression score was significantly higher in malignant tumors than in benign lesions (p=0.019). DUSP4 expression was significantly correlated with a larger tumor size (>2 cm, p=0.015). There was no significant correlation between overall survival or disease-free survival and DUSP4 expression in all 266 patients. We evaluated the impact of DUSP4 expression on the survival of 120 patients with T1-stage tumors. Interestingly, Kaplan-Meier survival curves revealed that DUSP4 expression had a significant effect on both overall patient survival (p=0.034, log-rank test) and disease-free survival (p=0.045, log-rank test). In early T-stage breast cancer, DUSP4 expression was associated with a worse prognosis.

Conclusion: DUSP4 is frequently upregulated in breast malignancy, and may play an important role in cancer development and progression. In addition, it may be a marker of adverse prognosis, especially in patients with early T1-stage cancer.

No MeSH data available.


Related in: MedlinePlus