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Perieccrine and pericapillary calcification in calciphylaxis.

Dookhan C, Ortega LM, Nayer A, Cho-Vega JH - J Renal Inj Prev (2015)

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Affiliation: Department of Internal Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.

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Medications included insulin, nifedipine, losartan, hydralazine, aspirin, gabapentin and calcium acetate... Physical examination revealed dusky red-purple discoloration of the left forefoot with a small ulcer on the great toe as well as dry gangrene of the right third and fourth toes and penis (Figure 1A-D)... However, calcium staining (Von Kossa) revealed subtle and stippled pericapillary and perieccrine calcification (Figure 1F,G)... Skin biopsy from the penis showed microvascular thrombosis and subtle pericapillary calcification... Calciphylaxis, also known as calcific uremic arteriolopathy, is characterized by ischemic tissue necrosis accompanied by medial calcification, intimal hyperplasia and thrombosis of small and medium-sized arteries... Vascular medial calcification may not be evident in skin biopsies stained with hematoxylin and eosin... Pericapillary and perieccrine calcification revealed by Von Kossa stain can aid in the diagnosis of calciphylaxis when frank vascular medial calcification is not evident on routinely processed skin biopsies... In addition, the extent of calcification on skin biopsies may not correlate with the severity of calciphylaxis... All authors wrote the manuscript equally... Ethical issues (including plagiarism, misconduct, data fabrication, falsification, double publication or submission, redundancy) have been completely observed by the authors... The authors declared no competing interests... None.

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Mentions: A 44-year-old Hispanic man presented with painful feet and penis. The past medical history was notable for end-stage renal disease, type 2 diabetes mellitus, hypertension, and peripheral vascular disease. The patient was on peritoneal dialysis. Medications included insulin, nifedipine, losartan, hydralazine, aspirin, gabapentin and calcium acetate. Physical examination revealed dusky red-purple discoloration of the left forefoot with a small ulcer on the great toe as well as dry gangrene of the right third and fourth toes and penis (Figure 1A-D). Laboratory tests demonstrated leukocytosis, anemia, hypoalbuminemia, vitamin D deficiency and secondary hyperparathyroidism (calcium 7.8 mg/dl, phosphate 10.7 mg/dl, parathyroid hormone 226 pg/ml). Cryoglobulins, lupus anticoagulant, and antibodies against nuclear antigens, myeloperoxidase, proteinase 3, hepatitis B and C viruses were not detected. Plain radiographs revealed diffuse vascular calcification of the feet. Computerized tomographic angiography demonstrated severe diffuse arterial calcification of the lower extremities. Echocardiography demonstrated preserved ejection fraction and no atrial septal defect. Skin biopsies showed epidermal and subcutaneous fat necrosis. No vascular calcification was noted in skin biopsies stained with hematoxylin and eosin (Figure 1E). However, calcium staining (Von Kossa) revealed subtle and stippled pericapillary and perieccrine calcification (Figure 1F,G). Skin biopsy from the penis showed microvascular thrombosis and subtle pericapillary calcification. Hospital course was notable for worsening ischemia of the left foot requiring a below-knee amputation. In the amputated leg, several medium-sized blood vessels in the subcutis showed intimal hyperplasia and medial calcification (Figure 1H).


Perieccrine and pericapillary calcification in calciphylaxis.

Dookhan C, Ortega LM, Nayer A, Cho-Vega JH - J Renal Inj Prev (2015)

© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4381033&req=5

Mentions: A 44-year-old Hispanic man presented with painful feet and penis. The past medical history was notable for end-stage renal disease, type 2 diabetes mellitus, hypertension, and peripheral vascular disease. The patient was on peritoneal dialysis. Medications included insulin, nifedipine, losartan, hydralazine, aspirin, gabapentin and calcium acetate. Physical examination revealed dusky red-purple discoloration of the left forefoot with a small ulcer on the great toe as well as dry gangrene of the right third and fourth toes and penis (Figure 1A-D). Laboratory tests demonstrated leukocytosis, anemia, hypoalbuminemia, vitamin D deficiency and secondary hyperparathyroidism (calcium 7.8 mg/dl, phosphate 10.7 mg/dl, parathyroid hormone 226 pg/ml). Cryoglobulins, lupus anticoagulant, and antibodies against nuclear antigens, myeloperoxidase, proteinase 3, hepatitis B and C viruses were not detected. Plain radiographs revealed diffuse vascular calcification of the feet. Computerized tomographic angiography demonstrated severe diffuse arterial calcification of the lower extremities. Echocardiography demonstrated preserved ejection fraction and no atrial septal defect. Skin biopsies showed epidermal and subcutaneous fat necrosis. No vascular calcification was noted in skin biopsies stained with hematoxylin and eosin (Figure 1E). However, calcium staining (Von Kossa) revealed subtle and stippled pericapillary and perieccrine calcification (Figure 1F,G). Skin biopsy from the penis showed microvascular thrombosis and subtle pericapillary calcification. Hospital course was notable for worsening ischemia of the left foot requiring a below-knee amputation. In the amputated leg, several medium-sized blood vessels in the subcutis showed intimal hyperplasia and medial calcification (Figure 1H).

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Internal Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Medications included insulin, nifedipine, losartan, hydralazine, aspirin, gabapentin and calcium acetate... Physical examination revealed dusky red-purple discoloration of the left forefoot with a small ulcer on the great toe as well as dry gangrene of the right third and fourth toes and penis (Figure 1A-D)... However, calcium staining (Von Kossa) revealed subtle and stippled pericapillary and perieccrine calcification (Figure 1F,G)... Skin biopsy from the penis showed microvascular thrombosis and subtle pericapillary calcification... Calciphylaxis, also known as calcific uremic arteriolopathy, is characterized by ischemic tissue necrosis accompanied by medial calcification, intimal hyperplasia and thrombosis of small and medium-sized arteries... Vascular medial calcification may not be evident in skin biopsies stained with hematoxylin and eosin... Pericapillary and perieccrine calcification revealed by Von Kossa stain can aid in the diagnosis of calciphylaxis when frank vascular medial calcification is not evident on routinely processed skin biopsies... In addition, the extent of calcification on skin biopsies may not correlate with the severity of calciphylaxis... All authors wrote the manuscript equally... Ethical issues (including plagiarism, misconduct, data fabrication, falsification, double publication or submission, redundancy) have been completely observed by the authors... The authors declared no competing interests... None.

No MeSH data available.