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The effects of probiotics on treatment of Helicobacter pylori eradication in children.

Akcam M, Koca T, Salman H, Karahan N - Saudi Med J (2015)

Bottom Line: Side effects of the drugs were recorded.No statistically significant difference was observed between the 2 groups in terms of side effects.We found no evidence in terms of eradication of H. pylori, or impact on adverse effects obtained after the addition of probiotics to standard treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Süleyman Demirel University, Isparta, Turkey. E-mail. makcam32@gmail.com.

ABSTRACT

Objectives: To investigate the eradication rates and side effects of probiotics added in standard triple therapy for the treatment of Helicobacter pylori (H. pylori).

Methods: A prospective open study was performed in the outpatient clinics of the Department of Pediatric Gastroenterology, School of Medicine, Suleyman Demirel University, Isparta, Turkey between March 2012 and May 2013. Sixty-one symptomatic children (range 7-18 years) with H. pylori infection were randomized to 2 groups: group 1 received standard triple therapy (lansoprazole, amoxicillin, and clarithromycin for 14 days), group 2 received the standard triple therapy plus probiotics (Lactobacillus casei, Lactobacillus acidophilus, and Bifidobacterium lactis). Side effects of the drugs were recorded. The 14C-urea breath test was performed for 6 weeks after discontinuation of the therapy.

Results: Helicobacter pylori infection was detected in 61 of 95 (64.2%) children. Fifty-six patients (38 girls and 18 boys) completed the study. Their mean age was 13.9 ± 2.7 years. Helicobacter pylori eradication rate was 68.9% in group 1, and 66.6% in group 2 (p=0.78). No statistically significant difference was observed between the 2 groups in terms of side effects.

Conclusion: We found no evidence in terms of eradication of H. pylori, or impact on adverse effects obtained after the addition of probiotics to standard treatment. Larger randomized controlled investigations are needed to clearly understand the effects of probiotics on H. pylori eradication.

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Study design and characteristics of enrolled children in a study on Helicobacter pylori eradication in Turkey.
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Figure 1: Study design and characteristics of enrolled children in a study on Helicobacter pylori eradication in Turkey.

Mentions: Helicobacter pylori infection was detected in 61 of 95 (64.2%) children. The study design and characteristics of enrolled children are shown in Figure 1. Of the 56 patients who completed the study, 38 were girls and 18 were boys, and the mean age was 13.9 ± 2.7 years. There was no significant difference between the groups in terms of age (p=0.33), and gender (p=0.85). The demographic characteristics and eradication rates of each group are presented in Table 1. The eradication rates were 68.9% in group 1, and 66.6% in group 2 (Table 1). There was no significant difference between the 2 groups (p=0.78). There were no significant differences between the 2 groups in terms of abdominal pain, nausea, vomiting, constipation, belching, taste problems, lack of appetite, diarrhea, or any other intolerance that would mandate the discontinuation of therapy at baseline, and days 7, 14, and 28 (Table 2). None of the patients developed serious side effects mandating discontinuation of therapy.


The effects of probiotics on treatment of Helicobacter pylori eradication in children.

Akcam M, Koca T, Salman H, Karahan N - Saudi Med J (2015)

Study design and characteristics of enrolled children in a study on Helicobacter pylori eradication in Turkey.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4381011&req=5

Figure 1: Study design and characteristics of enrolled children in a study on Helicobacter pylori eradication in Turkey.
Mentions: Helicobacter pylori infection was detected in 61 of 95 (64.2%) children. The study design and characteristics of enrolled children are shown in Figure 1. Of the 56 patients who completed the study, 38 were girls and 18 were boys, and the mean age was 13.9 ± 2.7 years. There was no significant difference between the groups in terms of age (p=0.33), and gender (p=0.85). The demographic characteristics and eradication rates of each group are presented in Table 1. The eradication rates were 68.9% in group 1, and 66.6% in group 2 (Table 1). There was no significant difference between the 2 groups (p=0.78). There were no significant differences between the 2 groups in terms of abdominal pain, nausea, vomiting, constipation, belching, taste problems, lack of appetite, diarrhea, or any other intolerance that would mandate the discontinuation of therapy at baseline, and days 7, 14, and 28 (Table 2). None of the patients developed serious side effects mandating discontinuation of therapy.

Bottom Line: Side effects of the drugs were recorded.No statistically significant difference was observed between the 2 groups in terms of side effects.We found no evidence in terms of eradication of H. pylori, or impact on adverse effects obtained after the addition of probiotics to standard treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Süleyman Demirel University, Isparta, Turkey. E-mail. makcam32@gmail.com.

ABSTRACT

Objectives: To investigate the eradication rates and side effects of probiotics added in standard triple therapy for the treatment of Helicobacter pylori (H. pylori).

Methods: A prospective open study was performed in the outpatient clinics of the Department of Pediatric Gastroenterology, School of Medicine, Suleyman Demirel University, Isparta, Turkey between March 2012 and May 2013. Sixty-one symptomatic children (range 7-18 years) with H. pylori infection were randomized to 2 groups: group 1 received standard triple therapy (lansoprazole, amoxicillin, and clarithromycin for 14 days), group 2 received the standard triple therapy plus probiotics (Lactobacillus casei, Lactobacillus acidophilus, and Bifidobacterium lactis). Side effects of the drugs were recorded. The 14C-urea breath test was performed for 6 weeks after discontinuation of the therapy.

Results: Helicobacter pylori infection was detected in 61 of 95 (64.2%) children. Fifty-six patients (38 girls and 18 boys) completed the study. Their mean age was 13.9 ± 2.7 years. Helicobacter pylori eradication rate was 68.9% in group 1, and 66.6% in group 2 (p=0.78). No statistically significant difference was observed between the 2 groups in terms of side effects.

Conclusion: We found no evidence in terms of eradication of H. pylori, or impact on adverse effects obtained after the addition of probiotics to standard treatment. Larger randomized controlled investigations are needed to clearly understand the effects of probiotics on H. pylori eradication.

Show MeSH
Related in: MedlinePlus