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Efficacy of triplet regimen antiemetic therapy for chemotherapy-induced nausea and vomiting (CINV) in bone and soft tissue sarcoma patients receiving highly emetogenic chemotherapy, and an efficacy comparison of single-shot palonosetron and consecutive-day granisetron for CINV in a randomized, single-blinded crossover study.

Kimura H, Yamamoto N, Shirai T, Nishida H, Hayashi K, Tanzawa Y, Takeuchi A, Igarashi K, Inatani H, Shimozaki S, Kato T, Aoki Y, Higuchi T, Tsuchiya H - Cancer Med (2014)

Bottom Line: The second aim was to compare the effectiveness of single-shot palonosetron and consecutive-day granisetron in a randomized, single-blinded crossover study.No significant differences were observed between single-shot palonosetron and consecutive-day granisetron.This study also demonstrated that consecutive-day granisetron was not inferior to single-shot palonosetron for treating CINV.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, 920-8641, Japan.

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The chemotherapy-induced nausea and vomiting control rate for the cisplatin plus doxorubicin chemotherapy regimen. Thirty-three courses with palonosetron and 32 courses with granisetron were evaluated for antiemetic therapy.
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fig05: The chemotherapy-induced nausea and vomiting control rate for the cisplatin plus doxorubicin chemotherapy regimen. Thirty-three courses with palonosetron and 32 courses with granisetron were evaluated for antiemetic therapy.

Mentions: When each chemotherapeutic regimen was analyzed, there were no significant differences in CR and TC rates between the palonosetron and granisetron regimens; these data are shown in Figure5 (AP regimen, the most highly emetic regimen) and Figure6 (IE and AI regimens).


Efficacy of triplet regimen antiemetic therapy for chemotherapy-induced nausea and vomiting (CINV) in bone and soft tissue sarcoma patients receiving highly emetogenic chemotherapy, and an efficacy comparison of single-shot palonosetron and consecutive-day granisetron for CINV in a randomized, single-blinded crossover study.

Kimura H, Yamamoto N, Shirai T, Nishida H, Hayashi K, Tanzawa Y, Takeuchi A, Igarashi K, Inatani H, Shimozaki S, Kato T, Aoki Y, Higuchi T, Tsuchiya H - Cancer Med (2014)

The chemotherapy-induced nausea and vomiting control rate for the cisplatin plus doxorubicin chemotherapy regimen. Thirty-three courses with palonosetron and 32 courses with granisetron were evaluated for antiemetic therapy.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4380959&req=5

fig05: The chemotherapy-induced nausea and vomiting control rate for the cisplatin plus doxorubicin chemotherapy regimen. Thirty-three courses with palonosetron and 32 courses with granisetron were evaluated for antiemetic therapy.
Mentions: When each chemotherapeutic regimen was analyzed, there were no significant differences in CR and TC rates between the palonosetron and granisetron regimens; these data are shown in Figure5 (AP regimen, the most highly emetic regimen) and Figure6 (IE and AI regimens).

Bottom Line: The second aim was to compare the effectiveness of single-shot palonosetron and consecutive-day granisetron in a randomized, single-blinded crossover study.No significant differences were observed between single-shot palonosetron and consecutive-day granisetron.This study also demonstrated that consecutive-day granisetron was not inferior to single-shot palonosetron for treating CINV.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, 920-8641, Japan.

Show MeSH
Related in: MedlinePlus