Efficacy of triplet regimen antiemetic therapy for chemotherapy-induced nausea and vomiting (CINV) in bone and soft tissue sarcoma patients receiving highly emetogenic chemotherapy, and an efficacy comparison of single-shot palonosetron and consecutive-day granisetron for CINV in a randomized, single-blinded crossover study.
Bottom Line: The second aim was to compare the effectiveness of single-shot palonosetron and consecutive-day granisetron in a randomized, single-blinded crossover study.No significant differences were observed between single-shot palonosetron and consecutive-day granisetron.This study also demonstrated that consecutive-day granisetron was not inferior to single-shot palonosetron for treating CINV.
Affiliation: Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, 920-8641, Japan.Show MeSH
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Mentions: When each chemotherapeutic regimen was analyzed, there were no significant differences in CR and TC rates between the palonosetron and granisetron regimens; these data are shown in Figure5 (AP regimen, the most highly emetic regimen) and Figure6 (IE and AI regimens).
Affiliation: Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, 920-8641, Japan.