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Deficits in error-monitoring by college students with schizotypal traits: an event-related potential study.

Kim SH, Jang KM, Kim MS - PLoS ONE (2015)

Bottom Line: Additionally, ERN amplitude measured at FCz was negatively correlated with the error rate on the Simon task in the schizotypal-trait group but not in the control group.The two groups did not differ in terms of correct-related potentials (CRN), error positivity (Pe) and correct-related positivity (Pc) amplitudes.The present results indicate that individuals with schizotypal traits have deficits in error-monitoring and that reduced ERN amplitudes may represent a biological marker of schizophrenia.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, Sungshin Women's University, Seoul, Republic of Korea.

ABSTRACT
The present study used event-related potentials (ERPs) to investigate deficits in error-monitoring by college students with schizotypal traits. Scores on the Schizotypal Personality Questionnaire (SPQ) were used to categorize the participants into schizotypal-trait (n = 17) and normal control (n = 20) groups. The error-monitoring abilities of the participants were evaluated using the Simon task, which consists of congruent (locations of stimulus and response are the same) and incongruent (locations of stimulus and response are different) conditions. The schizotypal-trait group committed more errors on the Simon task and exhibited smaller error-related negativity (ERN) amplitudes than did the control group. Additionally, ERN amplitude measured at FCz was negatively correlated with the error rate on the Simon task in the schizotypal-trait group but not in the control group. The two groups did not differ in terms of correct-related potentials (CRN), error positivity (Pe) and correct-related positivity (Pc) amplitudes. The present results indicate that individuals with schizotypal traits have deficits in error-monitoring and that reduced ERN amplitudes may represent a biological marker of schizophrenia.

No MeSH data available.


Related in: MedlinePlus

The grand-averaged ERPs and topographical distributions.A) The grand-averaged ERPs elicited by correct responses at Fz, FCz, Cz, and Pz for schizotypal-trait and control groups. B) Topographical distributions of CRN and Pc elicited by correct responses for schizotypal-trait and control groups.
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pone.0122861.g003: The grand-averaged ERPs and topographical distributions.A) The grand-averaged ERPs elicited by correct responses at Fz, FCz, Cz, and Pz for schizotypal-trait and control groups. B) Topographical distributions of CRN and Pc elicited by correct responses for schizotypal-trait and control groups.

Mentions: The time windows of ERN/Pe and CRN/Pc were determined following a visual inspection of the grand-averaged (Fig 2A and Fig 3A) and individual ERP waveforms. ERN/CRN were defined as the most negative peaks observed 50–150 ms after the onset of incorrect and correct responses, respectively, and Pe/Pc were defined as the most positive peaks observed 150–300 ms after the onset of incorrect and correct responses, respectively. The amplitudes and latencies of ERN/Pe and CRN/Pc were analyzed with mixed-design repeated measures analysis of variance (ANOVA) using electrode site as a within-subject factor (F3, F4, Fz, FC3, FC4, FCz, C3, C4, Cz, P3, P4 and Pz) and group (schizotypal-trait and control groups) as a between-subjects factor. In addition to midline electrode sites (Fz, FCz, Cz, and Pz), left (F3, FC3,C3, and P3) and right (F4, FC4, C4, and P4) sites were included in the analysis since a laterality effect on the Simon task in patients with schizophrenia was observed [51]. Green-Geisser corrections for violations of sphericity were used when appropriate, and the correct p values are reported. The associations between ERN/Pe and CRN/Pc amplitudes and error rates on the Simon task were examined using Pearson product-moment correlations. The demographic characteristics and the behavioral performances (response time and number of errors) were analyzed by means of independent t-tests.


Deficits in error-monitoring by college students with schizotypal traits: an event-related potential study.

Kim SH, Jang KM, Kim MS - PLoS ONE (2015)

The grand-averaged ERPs and topographical distributions.A) The grand-averaged ERPs elicited by correct responses at Fz, FCz, Cz, and Pz for schizotypal-trait and control groups. B) Topographical distributions of CRN and Pc elicited by correct responses for schizotypal-trait and control groups.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4380405&req=5

pone.0122861.g003: The grand-averaged ERPs and topographical distributions.A) The grand-averaged ERPs elicited by correct responses at Fz, FCz, Cz, and Pz for schizotypal-trait and control groups. B) Topographical distributions of CRN and Pc elicited by correct responses for schizotypal-trait and control groups.
Mentions: The time windows of ERN/Pe and CRN/Pc were determined following a visual inspection of the grand-averaged (Fig 2A and Fig 3A) and individual ERP waveforms. ERN/CRN were defined as the most negative peaks observed 50–150 ms after the onset of incorrect and correct responses, respectively, and Pe/Pc were defined as the most positive peaks observed 150–300 ms after the onset of incorrect and correct responses, respectively. The amplitudes and latencies of ERN/Pe and CRN/Pc were analyzed with mixed-design repeated measures analysis of variance (ANOVA) using electrode site as a within-subject factor (F3, F4, Fz, FC3, FC4, FCz, C3, C4, Cz, P3, P4 and Pz) and group (schizotypal-trait and control groups) as a between-subjects factor. In addition to midline electrode sites (Fz, FCz, Cz, and Pz), left (F3, FC3,C3, and P3) and right (F4, FC4, C4, and P4) sites were included in the analysis since a laterality effect on the Simon task in patients with schizophrenia was observed [51]. Green-Geisser corrections for violations of sphericity were used when appropriate, and the correct p values are reported. The associations between ERN/Pe and CRN/Pc amplitudes and error rates on the Simon task were examined using Pearson product-moment correlations. The demographic characteristics and the behavioral performances (response time and number of errors) were analyzed by means of independent t-tests.

Bottom Line: Additionally, ERN amplitude measured at FCz was negatively correlated with the error rate on the Simon task in the schizotypal-trait group but not in the control group.The two groups did not differ in terms of correct-related potentials (CRN), error positivity (Pe) and correct-related positivity (Pc) amplitudes.The present results indicate that individuals with schizotypal traits have deficits in error-monitoring and that reduced ERN amplitudes may represent a biological marker of schizophrenia.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, Sungshin Women's University, Seoul, Republic of Korea.

ABSTRACT
The present study used event-related potentials (ERPs) to investigate deficits in error-monitoring by college students with schizotypal traits. Scores on the Schizotypal Personality Questionnaire (SPQ) were used to categorize the participants into schizotypal-trait (n = 17) and normal control (n = 20) groups. The error-monitoring abilities of the participants were evaluated using the Simon task, which consists of congruent (locations of stimulus and response are the same) and incongruent (locations of stimulus and response are different) conditions. The schizotypal-trait group committed more errors on the Simon task and exhibited smaller error-related negativity (ERN) amplitudes than did the control group. Additionally, ERN amplitude measured at FCz was negatively correlated with the error rate on the Simon task in the schizotypal-trait group but not in the control group. The two groups did not differ in terms of correct-related potentials (CRN), error positivity (Pe) and correct-related positivity (Pc) amplitudes. The present results indicate that individuals with schizotypal traits have deficits in error-monitoring and that reduced ERN amplitudes may represent a biological marker of schizophrenia.

No MeSH data available.


Related in: MedlinePlus