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A Cohort Historical Analysis of the Relationship between Thyroid Hormone Malady and Alpha-Human Herpesvirus Activation.

Hsia SH, Hsia S V - J Steroids Horm Sci (2014)

Bottom Line: Using 2×2 contingency table analyses and Statistical Analysis Software (SAS), an Odds Ratio (OR) of 2.83 was observed for the total population of 21 years old and above with a chi-square of 61.55 and p < 0.001, confirming that a severe significant difference was found between these two cohorts.This result suggested that patients with αHHV diagnosis have higher chances to have TH disorders.These results indicated that TH dysfunction may have implication in αHHV pathogenesis and females exhibited much higher probability to suffer αHHV reactivation due to TH disruption.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Division of Pediatric Critical Care Medicine, Chang Gung Memorial Hospital, College of Medicine, Chang-Gung University, Kweishan, Taiwan.

ABSTRACT

Background: A number of physiological factors have been suggested to participate in the alpha- Human Herpesvirus (αHHV) reactivation, such as hormonal aberration. Thyroid hormone (TH) was shown to play a suppressive role in Herpes Simplex Virus Type-1 (HSV-1) gene expression and replication in cell culture and animal models. We hypothesize that reactivation of αHHV in humans may be due to, at least in part, by TH status.

Methods: Prior to implementing a full-scale population-based prospective inquiry into this hypothesis, a pilot study using a medical claims data base and a case-controlled, retrospective cohort investigation was conducted to develop a hypothetical link between TH complication and αHHV reactivation. Using diagnostic codes for treating thyroid disorders and αHHV infections as proxies for biologic/clinic outcomes, we queried a large, comprehensive hospital data base to construct two patient cohorts: Cohort 1 was comprised of patients receiving TH diagnoses over a twelve-year period, and Cohort 2 was composed of patients not receiving TH diagnoses during this period. Diagnoses of αHHV were recorded for each cohort and the difference in the frequency was examined for statistical significance. Demographic analyses such as age, gender, etc were also performed.

Results: Using 2×2 contingency table analyses and Statistical Analysis Software (SAS), an Odds Ratio (OR) of 2.83 was observed for the total population of 21 years old and above with a chi-square of 61.55 and p < 0.001, confirming that a severe significant difference was found between these two cohorts. This result suggested that patients with αHHV diagnosis have higher chances to have TH disorders. Additional investigation revealed that female were at higher/significant probability to have both TH and αHHV diagnosis, indicating a link of αHHV reactivation to a complex hormonal profile difference between genders. Our observation indicated that female patients of 21 years of age and above exhibited a very high incidence (OR of 3.40, p < 0.001) compared to the male groups (OR of 1.91, p < 0.05), indicating the possibility that hormonal alteration in females maybe transient but robust and can lead to αHHV reactivation more often than the males.

Conclusion: These results indicated that TH dysfunction may have implication in αHHV pathogenesis and females exhibited much higher probability to suffer αHHV reactivation due to TH disruption. Although the results from this pilot study have limitations and require additional controlled clinical examination such as more detailed patient records, lab data, therapeutic outcome, etc, it provides a tool to assess the effects of hormone imbalance on virus reactivation by retrospective analyses using existing large scale data base.

No MeSH data available.


Related in: MedlinePlus

Analyses of patients with TH diagnoses.A. TH diagnoses between 2001–2012B. Gender difference of patients suffering TH dysfunction from 2001–2012. The p value is <0.05.C. TH diagnoses in different age groups
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Figure 2: Analyses of patients with TH diagnoses.A. TH diagnoses between 2001–2012B. Gender difference of patients suffering TH dysfunction from 2001–2012. The p value is <0.05.C. TH diagnoses in different age groups

Mentions: Patients (both male and female) diagnosed with TH disorders increased gradually throughout the years and peaked in 2009–2010 and remained high in 2011 and 2012 (Figure 2A). Based on the existing records from the database (2001–2012), females had twice as much TH disorders than the males (Figure 2B). In addition, there was no gender difference regarding TH abnormality before twenty years of age (Figure 2C). However, TH dysfunction became a prominent issue for females over 21 years old compared to the male counterpart, especially for those who were 21–80 years of age (Figure 2C). As for the αHHV diagnoses, young patients under 20 in both genders had a very high numbers of hospitalization record (Figure 3A and 3B). There was no gender difference in adult αHHV diagnoses but the age group of 61–80 exhibited higher cases of virus-related hospitalization (Figure 3B).


A Cohort Historical Analysis of the Relationship between Thyroid Hormone Malady and Alpha-Human Herpesvirus Activation.

Hsia SH, Hsia S V - J Steroids Horm Sci (2014)

Analyses of patients with TH diagnoses.A. TH diagnoses between 2001–2012B. Gender difference of patients suffering TH dysfunction from 2001–2012. The p value is <0.05.C. TH diagnoses in different age groups
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4380329&req=5

Figure 2: Analyses of patients with TH diagnoses.A. TH diagnoses between 2001–2012B. Gender difference of patients suffering TH dysfunction from 2001–2012. The p value is <0.05.C. TH diagnoses in different age groups
Mentions: Patients (both male and female) diagnosed with TH disorders increased gradually throughout the years and peaked in 2009–2010 and remained high in 2011 and 2012 (Figure 2A). Based on the existing records from the database (2001–2012), females had twice as much TH disorders than the males (Figure 2B). In addition, there was no gender difference regarding TH abnormality before twenty years of age (Figure 2C). However, TH dysfunction became a prominent issue for females over 21 years old compared to the male counterpart, especially for those who were 21–80 years of age (Figure 2C). As for the αHHV diagnoses, young patients under 20 in both genders had a very high numbers of hospitalization record (Figure 3A and 3B). There was no gender difference in adult αHHV diagnoses but the age group of 61–80 exhibited higher cases of virus-related hospitalization (Figure 3B).

Bottom Line: Using 2×2 contingency table analyses and Statistical Analysis Software (SAS), an Odds Ratio (OR) of 2.83 was observed for the total population of 21 years old and above with a chi-square of 61.55 and p < 0.001, confirming that a severe significant difference was found between these two cohorts.This result suggested that patients with αHHV diagnosis have higher chances to have TH disorders.These results indicated that TH dysfunction may have implication in αHHV pathogenesis and females exhibited much higher probability to suffer αHHV reactivation due to TH disruption.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Division of Pediatric Critical Care Medicine, Chang Gung Memorial Hospital, College of Medicine, Chang-Gung University, Kweishan, Taiwan.

ABSTRACT

Background: A number of physiological factors have been suggested to participate in the alpha- Human Herpesvirus (αHHV) reactivation, such as hormonal aberration. Thyroid hormone (TH) was shown to play a suppressive role in Herpes Simplex Virus Type-1 (HSV-1) gene expression and replication in cell culture and animal models. We hypothesize that reactivation of αHHV in humans may be due to, at least in part, by TH status.

Methods: Prior to implementing a full-scale population-based prospective inquiry into this hypothesis, a pilot study using a medical claims data base and a case-controlled, retrospective cohort investigation was conducted to develop a hypothetical link between TH complication and αHHV reactivation. Using diagnostic codes for treating thyroid disorders and αHHV infections as proxies for biologic/clinic outcomes, we queried a large, comprehensive hospital data base to construct two patient cohorts: Cohort 1 was comprised of patients receiving TH diagnoses over a twelve-year period, and Cohort 2 was composed of patients not receiving TH diagnoses during this period. Diagnoses of αHHV were recorded for each cohort and the difference in the frequency was examined for statistical significance. Demographic analyses such as age, gender, etc were also performed.

Results: Using 2×2 contingency table analyses and Statistical Analysis Software (SAS), an Odds Ratio (OR) of 2.83 was observed for the total population of 21 years old and above with a chi-square of 61.55 and p < 0.001, confirming that a severe significant difference was found between these two cohorts. This result suggested that patients with αHHV diagnosis have higher chances to have TH disorders. Additional investigation revealed that female were at higher/significant probability to have both TH and αHHV diagnosis, indicating a link of αHHV reactivation to a complex hormonal profile difference between genders. Our observation indicated that female patients of 21 years of age and above exhibited a very high incidence (OR of 3.40, p < 0.001) compared to the male groups (OR of 1.91, p < 0.05), indicating the possibility that hormonal alteration in females maybe transient but robust and can lead to αHHV reactivation more often than the males.

Conclusion: These results indicated that TH dysfunction may have implication in αHHV pathogenesis and females exhibited much higher probability to suffer αHHV reactivation due to TH disruption. Although the results from this pilot study have limitations and require additional controlled clinical examination such as more detailed patient records, lab data, therapeutic outcome, etc, it provides a tool to assess the effects of hormone imbalance on virus reactivation by retrospective analyses using existing large scale data base.

No MeSH data available.


Related in: MedlinePlus